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Cardiotoxicity associated with tyrosine kinase inhibitor sunitinib
T. F. Chu, M. A. Rupnick, R. Kerkela, S. M. Dallabrida, D. Zurakowski, L. Nguyen, K. Woulfe, E. Pravda, F. Cassiola, J. Desai, S. George, J. A. Morgan, D. M. Harris, N. S. Ismail, J. H. Chen, F. J. Schoen, A. D. van den Abbeele, G. D. Demetri, T. Force, and M. H. Chen Lancet 370(9604):2011-2019 (2007)
to & Aged Agents Animals Antineoplastic Arteries Artery Blood Carcinoma Coronary Disease Failure Female Gastrointestinal Heart Humans Hypertension Indoles Kinase Kinases Male Mice Middle Multicenter Pressure Protein-Tyrosine Pyrroles Rats Research Retrospective Safety Stroke Stromal Studies Topic Tumors Tyrosine Volume adverse antagonists as blood chemically drug effects induced inhibitors methods therapeutic therapy toxicity use by kanefendt on Feb 5, 2010, 11:28 AM
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Molecular basis for sunitinib efficacy and future clinical development
S. Faivre, G. Demetri, W. Sargent, and E. Raymond Nat.Rev.Drug Discov. 6(9):734-745 (2007)
to & A Angiogenesis Animals Carcinoma Clinical Design Drug Endothelial Factor France Growth Humans Indoles Inhibitors Kinase Kinases Neoplasm Neoplasms Protein-Tyrosine Pyrroles Receptors Resistance Topic Trials Tyrosine Vascular adverse antagonists as biosynthesis blood drug effects enzymology inhibitors metabolism pharmacology response supply therapeutic therapy use by kanefendt on Feb 5, 2010, 11:28 AM
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Fit-for-purpose method development and validation for successful biomarker measurement
J. W. Lee, V. Devanarayan, Y. C. Barrett, R. Weiner, J. Allinson, S. Fountain, S. Keller, I. Weinryb, M. Green, L. Duan, J. A. Rogers, R. Millham, P. J. O'Brien, J. Sailstad, M. Khan, C. Ray, and J. A. Wagner Pharm.Res. 23(2):312-328 (2006)
to Approval Biological Calibration Chemistry Control Data Design Drug Interpretation Markers Models Quality Reproducibility Research Results Statistical Terminology Topic analysis as of by kanefendt on Feb 5, 2010, 11:28 AM
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Tyrosine kinase inhibitors of vascular endothelial growth factor receptors in clinical trials: current status and future directions
A. Morabito, Maio E. De, Maio M. Di, N. Normanno, and F. Perrone Oncologist. 11(7):753-764 (2006)
to & A Angiogenesis Clinical Endothelial Factor Growth Human Humans Inhibitors Kinase Kinases Lung Neoplasms Piperidines Protein Protein-Tyrosine Proteins Quinazolines Receptors Research Safety Topic Trials Tyrosine Vascular antagonists as drug inhibitors metabolism protein therapeutic therapy use by kanefendt on Feb 5, 2010, 11:28 AM
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Possible molecular mechanisms involved in the toxicity of angiogenesis inhibition
H. M. Verheul, and H. M. Pinedo Nat.Rev.Cancer 7(6):475-485 (2007)
to & A Administration Agents Angiogenesis Antineoplastic Biological Blood Clinical Coagulation Drug Endothelial Factor Function Growth Humans Hypertension Inhibitors Left Models Neoplasm Platelets Research Resistance Schedule Signal Thrombosis Topic Transduction Trials Vascular Ventricular administration adverse antagonists as chemically dosage drug effects etiology induced inhibitors physiology toxicity by kanefendt on Feb 5, 2010, 11:28 AM
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Quantitative bioanalytical methods validation and implementation: best practices for chromatographic and ligand binding assays
C. T. Viswanathan, S. Bansal, B. Booth, A. J. DeStefano, M. J. Rose, J. Sailstad, V. P. Shah, J. P. Skelly, P. G. Swann, and R. Weiner Pharm.Res. 24(10):1962-1973 (2007)
to & Administration Animals Artifacts Assay Binding Biological Body Calibration Chemistry Chromatography Control Documentation Drug Fluids Food Government Guidelines Humans Macromolecular Pharmaceutical Quality Radioligand Reference Regulation Reproducibility Research Results Species Specificity Stability Standards States Substances Technology Topic United and as jurisprudence legislation methods of standards by kanefendt on Feb 5, 2010, 11:28 AM
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Biomarker method validation in anticancer drug development
J. Cummings, T. H. Ward, A. Greystoke, M. Ranson, and C. Dive Br.J.Pharmacol. 153(4):646-656 (2008)
to & Adherence Agents Animals Antineoplastic Assay Biomarkers Cell Clinical Control Death Drug Enzyme-Linked Europe Evaluation Guideline Guidelines Humans Immunosorbent Keratin-18 Laboratories Mass Pharmacological Preclinical Proteins Quality Reproducibility Research Results Spectrometry Terminology Topic Trials analysis as drug effects jurisprudence legislation methods of pharmacology protein standards therapeutic use by kanefendt on Feb 5, 2010, 11:28 AM
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EGFR FISH versus mutation: different tests, different end-points
F. Cappuzzo Lung Cancer 60(2):160-165 (2008)
to & Analysis Carcinoma Clinical DNA Drug Epidermal Factor Fluorescence Growth Humans Hybridization In Inhibitors Kinase Lung Mutation Mutational Neoplasm Neoplasms Non-Small-Cell Patient Population Protein Receptor Resistance Selection Situ Topic Trials Tyrosine analysis antagonists as drug genetics identify inhibitors protein response therapeutic therapy use by kanefendt on Feb 5, 2010, 11:28 AM
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Antiangiogenesis research is booming, as questions and studies proliferate
V. Brower J.Natl.Cancer Inst. 101(11):780-781 (2009)
to & Administration Analysis Angiogenesis Antibodies Antineoplastic Biological Chemotherapy Colorectal Combined Controlled Drug Humans Inhibitors Markers Monoclonal Neoplasms Pericytes Protocols Randomized Research Schedule Survival Topic Trials Tumor administration analysis as blood dosage drug effects mortality supply therapeutic therapy use by kanefendt on Feb 5, 2010, 11:28 AM
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Biomarkers of angiogenesis for the development of antiangiogenic therapies in oncology: tools or decorations?
C. Sessa, A. Guibal, Conte G. Del, and C. Ruegg Nat.Clin.Pract.Oncol. 5(7):378-391 (2008)
to Angiogenesis Antibodies Benzenesulfonates Biological Clinical Humans Indoles Inhibitors Markers Monoclonal Neoplasms Neovascularization Pathologic Pyridines Pyrroles Research Topic Trials Tumor as drug metabolism therapeutic therapy use by kanefendt on Feb 5, 2010, 11:28 AM
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Data-reduction methods for immunoradiometric assays of thyrotropin compared
M. C. Haven, P. J. Orsulak, L. L. Arnold, and G. Crowley Clin.Chem. 33(7):1207-1210 (1987)
to Diagnostic Humans Hyperthyroidism Hypothyroidism Immunoassay Iodine Kits Mathematics Radioisotopes Reagent Software Statistics Thyrotropin Topic as blood methods by kanefendt on Feb 5, 2010, 11:28 AM
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An analysis of the Washington Conference Report on bioanalytical method validation
C. Hartmann, D. L. Massart, and R. D. McDowall J.Pharm.Biomed.Anal. 12(11):1337-1343 (1994)
to Analytical Chemistry Guidelines Reproducibility Results Statistics Terminology Topic analysis as methods of standards by kanefendt on Feb 5, 2010, 11:28 AM
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Different efficacy of various blocking reagents to eliminate interferences by human antimouse antibodies with a two-site immunoassay
J. Reinsberg Clin.Biochem. 29(2):145-148 (1996)
to Analysis Animals Antibodies Antigen Blocking Blood CA-125 Chemical Evaluation False Heterophile Human Humans Immunoassay Indicators Mice Positive RANGE Reactions Reagents Studies Topic and as blood methods by kanefendt on Feb 5, 2010, 11:28 AM
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Method validation and measurement of biomarkers in nonclinical and clinical samples in drug development: a conference report
J. W. Lee, R. S. Weiner, J. M. Sailstad, R. R. Bowsher, D. W. Knuth, P. J. O'Brien, J. L. Fourcroy, R. Dixit, L. Pandite, R. G. Pietrusko, H. D. Soares, V. Quarmby, O. L. Vesterqvist, D. M. Potter, J. L. Witliff, H. A. Fritche, T. O'Leary, L. Perlee, S. Kadam, and J. A. Wagner Pharm.Res. 22(4):499-511 (2005)
to Assay Biological Chemistry Clinical Markers Pharmaceutical Reproducibility Research Results Topic Trials analysis as methods of standards toxicity trends by kanefendt on Feb 5, 2010, 11:28 AM
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The biology of VEGF and its receptors
N. Ferrara, H. P. Gerber, and J. LeCouter Nat.Med. 9(6):669-676 (2003)
to A Animals Clinical Dna Endothelial Endothelium Factor Factors Growth Humans Intercellular Isoforms Lymphokines Neovascularization Oxygen Pathologic Peptides Physiologic Protein Proteins Receptors Signal Signaling Substances Topic Transduction Trials Tyrosine Vascular and as cytology genetics metabolism physiology protein therapeutic use by kanefendt on Feb 5, 2010, 11:28 AM
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Surrogate markers in antiangiogenesis clinical trials
D. W. Davis, D. J. McConkey, J. L. Abbruzzese, and R. S. Herbst Br.J.Cancer 89(1):8-14 (2003)
to Angiogenesis Biological Biopsy Clinical Confocal Humans Inhibitors Markers Microscopy Neoplasms Outcome Topic Treatment Trials Tumor analysis as drug methods pharmacology physiopathology therapy by kanefendt on Feb 5, 2010, 11:28 AM
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Expression profiling of blood samples from an SU5416 Phase III metastatic colorectal cancer clinical trial: a novel strategy for biomarker identification
S. E. Deprimo, L. M. Wong, D. B. Khatry, S. L. Nicholas, W. C. Manning, B. D. Smolich, A. M. O'Farrell, and J. M. Cherrington BMC.Cancer (2003)
to & 9 Aged Analysis Angiogenesis Antigens Array Biological Biopsy CD CD24 Chain Chemistry Clinical Colorectal Expression Female Gene Glycoproteins Human Humans III Indoles Inhibitors Kinase Kinases Lactoferrin Leukocytes Male Markers Matrix Membrane Metalloproteinase Metastasis Middle Mononuclear Neoplasm Neoplasms Neoplastic Oligonucleotide Phase Polymerase Predictive Profiling Protein-Tyrosine Pyrroles Reaction Regulation Research Reverse Sequence Tests Topic Transcriptase Trials Tumor Tyrosine Value analysis antagonists as blood cells drug genetics identify inhibitors metabolism methods of protein response therapeutic therapy use by kanefendt on Feb 5, 2010, 11:28 AM
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Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy
H. F. Dvorak J.Clin.Oncol. 20(21):4368-4380 (2002)
to A Capillary Cell Clinical Division Endothelial Expression Factor Factors Gene Growth Humans Intercellular Isoforms Lymphokines Movement Neoplasms Neoplastic Neovascularization Pathologic Peptides Permeability Prognosis Protein Proteins Regulation Research Signaling Topic Trials Vascular and as cells pathology pharmacology physiopathology protein therapeutic therapy use by kanefendt on Feb 5, 2010, 11:28 AM
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