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Tumor microvasculature and microenvironment: targets for anti-angiogenesis and normalization
D. Fukumura, and R. K. Jain Microvasc.Res. 74(2-3):72-84 (2007)
to & Angiogenesis Animals Blood Endothelial Factors Growth Humans Inhibitors Laboratories Neoplasms Neovascularization Pathologic Research Vascular Vessels antagonists blood cells drug inhibitors pathology supply therapeutic therapy use by kanefendt on Feb 5, 2010, 11:28 AM
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Vascular endothelial growth factor receptor 3 is involved in tumor angiogenesis and growth
P. Laakkonen, M. Waltari, T. Holopainen, T. Takahashi, B. Pytowski, P. Steiner, D. Hicklin, K. Persaud, J. R. Tonra, L. Witte, and K. Alitalo Cancer Res. 67(2):593-599 (2007)
to & Animals Antibodies Antitumor Assays BALB Binding C Cell D Endothelial Factor Growth Human Humans Immunohistochemistry Inbred Ligands Mice Model Monoclonal Neoplasms Neovascularization Nude Pathologic Processes Receptor-3 Research Vascular Xenograft analysis antagonists blood immunology inhibitors metabolism pharmacology supply therapy by kanefendt on Feb 5, 2010, 11:28 AM
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Surrogate biomarkers in evaluating response to anti-angiogenic agents: focus on sunitinib
S. E. Deprimo, and C. Bello Ann.Oncol (2007)
to Angiogenesis Biological Cells Endothelial Growth Humans Indoles Inhibitors Laboratories Markers Neoplasms Neovascularization Pathologic Proteins Pyrroles Research Tumor blood cells diagnosis drug effects metabolism methods pathology pharmacology protein response supply therapeutic therapy use by kanefendt on Feb 5, 2010, 11:28 AM
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Molecular and cellular biomarkers for angiogenesis in clinical oncology
F. Bertolini, P. Mancuso, Y. Shaked, and R. S. Kerbel Drug Discov.Today 12(19-20):806-812 (2007)
to Angiogenesis Antigens Biological Cells Endothelial Humans Inhibitors Markers Microcirculation Neoplasms Neovascularization Pathologic Research Tumor blood cells diagnosis drug metabolism pathology pharmacology supply therapeutic therapy use by kanefendt on Feb 5, 2010, 11:28 AM
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Molecular basis for sunitinib efficacy and future clinical development
S. Faivre, G. Demetri, W. Sargent, and E. Raymond Nat.Rev.Drug Discov. 6(9):734-745 (2007)
to & A Angiogenesis Animals Carcinoma Clinical Design Drug Endothelial Factor France Growth Humans Indoles Inhibitors Kinase Kinases Neoplasm Neoplasms Protein-Tyrosine Pyrroles Receptors Resistance Topic Trials Tyrosine Vascular adverse antagonists as biosynthesis blood drug effects enzymology inhibitors metabolism pharmacology response supply therapeutic therapy use by kanefendt on Feb 5, 2010, 11:28 AM
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Molecular regulation of tumor angiogenesis: mechanisms and therapeutic implications
J. Harper, and M. A. Moses EXS (2006)
to & Angiogenesis Capillaries Human Humans Inhibitors Neoplasms Neovascularization Pathologic Research blood control drug metabolism pathology pharmacology prevention supply therapeutic therapy use by kanefendt on Feb 5, 2010, 11:28 AM
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Vascular endothelial growth factor-D and its receptor VEGFR-3: two novel independent prognostic markers in gastric adenocarcinoma
S. Juttner, C. Wissmann, T. Jons, M. Vieth, J. Hertel, S. Gretschel, P. M. Schlag, W. Kemmner, and M. Hocker J.Clin.Oncol. 24(2):228-240 (2006)
to 80 Adenocarcinoma Adult Aged Antibodies C Cell Chemistry D Disease-Free Endothelial Factor Growth Humans Immunohistochemistry Laboratories Line Lymphatic Messenger Metastasis Middle Neoplasms Prognosis RNA Receptor-3 Research Stomach Survival Tumor Vascular analysis and blood genetics identify methods mortality over supply by kanefendt on Feb 5, 2010, 11:28 AM
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The clinical toxicity profile of vascular endothelial growth factor VEGF and vascular endothelial growth factor receptor VEGFR targeting angiogenesis inhibitors; a review
F. A. Eskens, and J. Verweij Eur.J.Cancer 42(18):3127-3139 (2006)
to & A Angiogenesis Antibodies Endothelial Factor Growth Humans Inhibitors Kinase Kinases Medical Monoclonal Neoplasms Neovascularization Oncology Pathologic Protein Protein-Tyrosine Receptors Tyrosine Vascular adverse antagonists blood control drug effects inhibitors prevention protein supply therapy toxicity by kanefendt on Feb 5, 2010, 11:28 AM
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Notch signaling in the regulation of tumor angiogenesis
A. O. Rehman, and C. Y. Wang Trends Cell Biol. 16(6):293-300 (2006)
to & Agents Angiogenesis Animals Binding Biological Blood Carcinogens Cells Endothelial Genes Humans Inducing Inhibitors Laboratories Ligands Models Neoplasms Neovascularization Notch Pathologic Receptors Signal Suppressor Transduction Tumor Vessels blood cells development growth metabolism physiology supply therapy by kanefendt on Feb 5, 2010, 11:28 AM
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Differential roles of vascular endothelial growth factor receptor-1 and receptor-2 in angiogenesis
M. Shibuya J Biochem.Mol.Biol. 39(5):469-478 (2006)
to A Animals Atherosclerosis Cells Chemistry Development Dna Embryonic Endothelial Factor Female Growth Human Humans Inflammation Japan Metastasis Mice Neoplasm Neoplasms Neovascularization Pathologic Physiologic Pre-Eclampsia Pregnancy Proteins Receptor-1 Receptor-2 Research Signal Transduction Tyrosine Vascular Viral blood cells genetics metabolism physiology physiopathology protein response supply therapy by kanefendt on Feb 5, 2010, 11:28 AM
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Soluble angiogenesis markers in gastric tumor patients
P. Mysliwiec, K. Pawlak, R. Bandurski, and B. Kedra Folia Histochem.Cytobiol. 47(1):81-86 (2009)
to A Adult Aged Antigens Biological CD Care Case-Control Cell Endothelial Factor Female Growth Human Humans Male Markers Middle Neoplasms Neovascularization Pathologic Plasma Preoperative Receptor-2 Receptors Solubility Stomach Studies Surface Tumor Vascular blood metabolism protein supply surgery by kanefendt on Feb 5, 2010, 11:28 AM
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How well do angiogenesis inhibitors work? Biomarkers of response prove elusive
V. Brower J.Natl.Cancer Inst. 101(12):846-847 (2009)
to A Analysis Angiogenesis Animals Antibodies Benzenesulfonates Biological Cells Cytokines Disease-Free Endothelial Factor Growth Humans Indoles Inhibitors Markers Monoclonal Neoplasms Pyridines Pyrroles Survival Tumor Vascular blood drug effects metabolism mortality pathology pharmacology response supply therapeutic therapy use by kanefendt on Feb 5, 2010, 11:28 AM
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Phase I dose escalation study of telatinib, a tyrosine kinase inhibitor of vascular endothelial growth factor receptor 2 and 3, platelet-derived growth factor receptor beta, and c-Kit, in patients with advanced or metastatic solid tumors
F. A. Eskens, N. Steeghs, J. Verweij, J. L. Bloem, O. Christensen, Doorn L. van, J. Ouwerkerk, M. J. Jonge, J. W. Nortier, J. Kraetzschmar, P. Rajagopalan, and H. Gelderblom J.Clin.Oncol. 27(25):4169-4176 (2009)
to & A Administration Adolescent Adult Aged Angiogenesis Biological Contrast Dose Dose-Response Drug Endothelial Factor Factors Fatigue Female Growth Human Humans Hypertension Imaging Inhibitors Kinase Magnetic Male Markers Maximum Media Medical Metastasis Middle Neoplasm Neoplasms Oncology Oral Outcome Pharmacokinetics Plasma Platelet-Derived Protein Proteins Proto-Oncogene Pyridazines Pyridines Receptor Receptor-2 Receptor-3 Relationship Research Resonance Safety Schedule Time Tolerated Treatment Tumor Tyrosine Vascular Young administration adverse antagonists beta blood c-kit diagnostic dosage drug effects enzymology inhibitors methods pathology protein response supply therapy toxicity use by kanefendt on Feb 5, 2010, 11:28 AM
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Antiangiogenesis research is booming, as questions and studies proliferate
V. Brower J.Natl.Cancer Inst. 101(11):780-781 (2009)
to & Administration Analysis Angiogenesis Antibodies Antineoplastic Biological Chemotherapy Colorectal Combined Controlled Drug Humans Inhibitors Markers Monoclonal Neoplasms Pericytes Protocols Randomized Research Schedule Survival Topic Trials Tumor administration analysis as blood dosage drug effects mortality supply therapeutic therapy use by kanefendt on Feb 5, 2010, 11:28 AM
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Biomarkers of response and resistance to antiangiogenic therapy
R. K. Jain, D. G. Duda, C. G. Willett, D. V. Sahani, A. X. Zhu, J. S. Loeffler, T. T. Batchelor, and A. G. Sorensen Nat.Rev.Clin.Oncol. 6(6):327-338 (2009)
to & A Angiogenesis Biological Drug Endothelial Factor Growth Humans Hypertension Inhibitors Markers Neoplasm Neoplasms Neovascularization Pathologic Research Resistance Tumor Vascular antagonists blood control inhibitors metabolism prevention response supply therapeutic therapy use by kanefendt on Feb 5, 2010, 11:28 AM
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Endothelial VEGFR-3 expression in colorectal carcinomas is associated with hematogenous metastasis
C. Jayasinghe, N. Simiantonaki, R. Michel-Schmidt, and C. J. Kirkpatrick Oncol.Rep. 22(5):1093-1100 (2009)
to Antibody Assay Blood Carcinoma Cell Cells Colon Colorectal Cytometry Endothelial Endothelium Enzyme-Linked Factor Flow Fluorescent Growth Human Humans Hypoxia Immunoenzyme Immunohistochemistry Immunosorbent Lymphatic Metastasis Neoplasm Neoplasms Neovascularization Pathologic Prognosis Receptor-3 Technique Techniques Vascular Vessels blood cells metabolism pathology protein supply by kanefendt on Feb 5, 2010, 11:28 AM
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Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation
T. Tammela, G. Zarkada, E. Wallgard, A. Murtomaki, S. Suchting, M. Wirzenius, M. Waltari, M. Hellstrom, T. Schomber, R. Peltonen, C. Freitas, A. Duarte, H. Isoniemi, P. Laakkonen, G. Christofori, S. Yla-Herttuala, M. Shibuya, B. Pytowski, A. Eichmann, C. Betsholtz, and K. Alitalo Nature 454(7204):656-660 (2008)
to & Adult Angiogenesis Animals Antibodies BALB Blood C Cell Cells Dipeptides Down-Regulation Endothelial Endothelium Expression Factor Factors Female Gene Growth Humans Inbred Inhibitors Laboratories Ligands Line Lymphangiogenesis Mice Monoclonal Neoplasms Neoplastic Neovascularization Notch Pathologic Proliferation Receptor-3 Receptors Regulation Research Signal Transduction Transgenic Tumor Tyrosine Vascular Vessels antagonists blood cells drug effects genetics inhibitors metabolism pharmacology supply therapy by kanefendt on Feb 5, 2010, 11:28 AM
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Tumor angiogenesis
R. S. Kerbel N.Engl.J.Med. 358(19):2039-2049 (2008)
to A Angiogenesis Animals Bone Cells Drug Endothelial Factor Growth Human Humans Inhibitors Marrow Neoplasm Neoplasms Neovascularization Notch Pathologic Proteins Proto-Oncogene Receptors Research Resistance Signal Transduction Vascular blood drug physiology physiopathology protein supply therapeutic therapy use by kanefendt on Feb 5, 2010, 11:28 AM
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VEGFR-3 expression is restricted to blood and lymphatic vessels in solid tumors
T. V. Petrova, P. Bono, W. Holnthoner, J. Chesnes, B. Pytowski, H. Sihto, P. Laakkonen, P. Heikkila, H. Joensuu, and K. Alitalo Cancer Cell 13(6):554-556 (2008)
to Antibodies Antibody Blood Blotting Cell Cells Chain Chemistry Cytometry Endothelial Factor Flow Growth Humans Immunohistochemistry Line Lymphatic Messenger Neoplasms Northern Polymerase RNA Reaction Receptor-3 Reproducibility Results Reverse Separation Specificity Transcriptase Tumor Vascular Vessels Western analysis blood genetics immunology methods of pathology supply by kanefendt on Feb 5, 2010, 11:28 AM
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VEGFs, receptors and angiogenesis
T. Veikkola, and K. Alitalo Semin.Cancer Biol. 9(3):211-220 (1999)
to A Animals Blood Endothelial Factor Factors Growth Humans Kinase Kinases Laboratories Lymphokines Neoplasms Neovascularization Pathologic Physiologic Protein-Tyrosine Receptor Receptors Research Vascular Vessels blood etiology physiology supply by kanefendt on Feb 5, 2010, 11:28 AM
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