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Pleiotropic effects of Pasteurella multocida toxin are mediated by Gq-dependent and -independent mechanisms. involvement of Gq but not G11
A. Zywietz, A. Gohla, M. Schmelz, G. Schultz, and S. Offermanns. J Biol Chem 276(6):3840-5 (February 2001)Zywietz, A Gohla, A Schmelz, M Schultz, G Offermanns, S Research Support, Non-U.S. Gov't United States The Journal of biological chemistry J Biol Chem. 2001 Feb 9;2766:3840-5. Epub 2000 Nov 2..
A. Zywietz, A. Gohla, M. Schmelz, G. Schultz, and S. Offermanns. J Biol Chem 276(6):3840-5 (February 2001)Zywietz, A Gohla, A Schmelz, M Schultz, G Offermanns, S Research Support, Non-U.S. Gov't United States The Journal of biological chemistry J Biol Chem. 2001 Feb 9;2766:3840-5. Epub 2000 Nov 2..
2 years and 6 months ago
by pharmawuerz
2
*Bacterial Animals Bacterial Cultured GTP-Binding Gohla Gq-G11 Heterotrimeric Mice Pasteurella Phosphorylation Protein Proteins Proteins/metabolism/*physiology Subunits, Toxins/*pharmacology alpha multocida/*metabolism Cell
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Study of interaction between agonists and asn293 in helix VI of human beta2-adrenergic receptor
H. M. Zuurmond, J. Hessling, K. Bluml, M. Lohse, and A. P. Ijzerman. Mol Pharmacol 56(5):909-16 (November 1999)Zuurmond, H M Hessling, J Bluml, K Lohse, M Ijzerman, A P Research Support, Non-U.S. Gov't United states Molecular pharmacology Mol Pharmacol. 1999 Nov;565:909-16..
H. M. Zuurmond, J. Hessling, K. Bluml, M. Lohse, and A. P. Ijzerman. Mol Pharmacol 56(5):909-16 (November 1999)Zuurmond, H M Hessling, J Bluml, K Lohse, M Ijzerman, A P Research Support, Non-U.S. Gov't United states Molecular pharmacology Mol Pharmacol. 1999 Nov;565:909-16..
2 years and 6 months ago
by pharmawuerz
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& Adrenergic Animals Asparagine/*metabolism Binding, CHO Clenbuterol/analogs Competitive Cricetinae Humans Isoproterenol/analogs Ligands Models, Molecular Protein Secondary Spectrophotometry, Structure, Ultraviolet beta-2/chemistry/genetics/*metabolism beta-Agonists/chemical derivatives/chemical synthesis/*pharmacology synthesis/pharmacology Receptor Cell
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Fluorescence resonance energy transfer analysis of alpha 2a-adrenergic receptor activation reveals distinct agonist-specific conformational changes
A. Zurn, U. Zabel, J. P. Vilardaga, H. Schindelin, M. J. Lohse, and C. Hoffmann. Mol Pharmacol 75(3):534-41 (March 2009)Zurn, A Zabel, U Vilardaga, J-P Schindelin, H Lohse, M J Hoffmann, C Comparative Study Research Support, Non-U.S. Gov't United States Molecular pharmacology Mol Pharmacol. 2009 Mar;753:534-41. Epub 2008 Dec 23..
A. Zurn, U. Zabel, J. P. Vilardaga, H. Schindelin, M. J. Lohse, and C. Hoffmann. Mol Pharmacol 75(3):534-41 (March 2009)Zurn, A Zabel, U Vilardaga, J-P Schindelin, H Lohse, M J Hoffmann, C Comparative Study Research Support, Non-U.S. Gov't United States Molecular pharmacology Mol Pharmacol. 2009 Mar;753:534-41. Epub 2008 Dec 23..
2 years and 6 months ago
by pharmawuerz
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Adrenergic Agonists/metabolism/*pharmacology Animals Binding/drug Cell Clonidine/metabolism Conformation/drug Dopamine/metabolism Energy Fluorescence Humans Ligands Line Mice Norepinephrine/metabolism Octopamine/metabolism Protein Resonance Transfer/methods alpha-2/*agonists/*chemistry/metabolism effects effects/physiology Receptor
(0)
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A new synthesis of sulfonamides by aminolysis of p-nitrophenylsulfonates yielding potent and selective adenosine A2B receptor antagonists
L. Yan, D. C. Bertarelli, A. M. Hayallah, H. Meyer, K. N. Klotz, and C. E. Muller. J Med Chem 49(14):4384-91 (July 2006)Yan, Luo Bertarelli, Daniela C G Hayallah, Alaa M Meyer, Heiko Klotz, Karl-Norbert Muller, Christa E In Vitro Research Support, Non-U.S. Gov't United States Journal of medicinal chemistry J Med Chem. 2006 Jul 13;4914:4384-91..
L. Yan, D. C. Bertarelli, A. M. Hayallah, H. Meyer, K. N. Klotz, and C. E. Muller. J Med Chem 49(14):4384-91 (July 2006)Yan, Luo Bertarelli, Daniela C G Hayallah, Alaa M Meyer, Heiko Klotz, Karl-Norbert Muller, Christa E In Vitro Research Support, Non-U.S. Gov't United States Journal of medicinal chemistry J Med Chem. 2006 Jul 13;4914:4384-91..
2 years and 6 months ago
by pharmawuerz
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& A2B/*antagonists Adenosine Animals Arylsulfonates/*chemistry Assay Brain/metabolism CHO Cricetinae Cricetulus Humans Proteins/antagonists Radioligand Rats Recombinant Relationship Structure-Activity Sulfonamides/*chemical Xanthines/*chemical inhibitors synthesis/chemistry/pharmacology Receptor Cell
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Circadian and short-term regulation of blood pressure and heart rate in transgenic mice with cardiac overexpression of the beta1-adrenoceptor
K. Witte, S. Engelhardt, B. J. Janssen, M. Lohse, and B. Lemmer. Chronobiol Int 21(2):205-16 (March 2004)Witte, Klaus Engelhardt, Stefan Janssen, Ben J A Lohse, Martin Lemmer, Bjorn United States Chronobiology international Chronobiol Int. 2004 Mar;212:205-16..
K. Witte, S. Engelhardt, B. J. Janssen, M. Lohse, and B. Lemmer. Chronobiol Int 21(2):205-16 (March 2004)Witte, Klaus Engelhardt, Stefan Janssen, Ben J A Lohse, Martin Lemmer, Bjorn United States Chronobiology international Chronobiol Int. 2004 Mar;212:205-16..
2 years and 6 months ago
by pharmawuerz
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& Activity/physiology Adrenergic Animals Blood Circadian Failure/metabolism Heart Heart/*physiology Humans Male Mice Motor Pressure/*physiology Propranolol/administration Rate/*physiology Rhythm/*physiology Telemetry Transgenic beta-1/genetics/*metabolism beta-Antagonists/administration dosage/metabolism Receptor
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The galanin receptor type 2 initiates multiple signaling pathways in small cell lung cancer cells by coupling to Gq, Gi and G12 proteins
N. Wittau, R. Grosse, F. Kalkbrenner, A. Gohla, G. Schultz, and T. Gudermann. Oncogene 19(37):4199-209 (August 2000)Wittau, N Grosse, R Kalkbrenner, F Gohla, A Schultz, G Gudermann, T England Oncogene Oncogene. 2000 Aug 31;1937:4199-209..
N. Wittau, R. Grosse, F. Kalkbrenner, A. Gohla, G. Schultz, and T. Gudermann. Oncogene 19(37):4199-209 (August 2000)Wittau, N Grosse, R Kalkbrenner, F Gohla, A Schultz, G Gudermann, T England Oncogene Oncogene. 2000 Aug 31;1937:4199-209..
2 years and 6 months ago
by pharmawuerz
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& 1-Methyl-3-isobutylxanthine/pharmacology 1/metabolism 2 3 3T3 AMP/physiology Actins/metabolism Adhesion Animals Bordetella/pharmacology C C/antagonists COS Calcium Carcinoma, Cell Cell/metabolism/*pathology Cells/drug Cultured/metabolism Cyclic Diacylglycerol-Lyase Enzyme Factors, Fusion G12-G13 GTP-Binding Galanin Galanin, Galanin/metabolism/pharmacology Gi-Go/*physiology Gohla Gq-G11 Heterotrimeric Humans Indoles/pharmacology Inhibitors/pharmacology Inositol Intracellular Isoproterenol/pharmacology Kinase Kinases Kinases/metabolism Kinases/physiology Lung Maleimides/pharmacology Mice Microfilaments/metabolism Mitogen-Activated Neoplasm Neoplasms/metabolism/*pathology Neuropeptide/drug Peptides Pertussis Phosphates/metabolism Phosphatidylinositol Phospholipases/metabolism Protein Protein-Serine-Threonine Protein/physiology Proteins Proteins/*physiology Proteins/antagonists Proteins/genetics/physiology Recombinant Signaling Signaling/drug Small Subunits, Toxin Transfection Tumor Type Virulence alpha and effects effects/*physiology inhibitors/*physiology inhibitors/physiology rho-Associated rhoA Receptor
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Protein kinase cross-talk: membrane targeting of the beta-adrenergic receptor kinase by protein kinase C
R. Winstel, S. Freund, C. Krasel, E. Hoppe, and M. J. Lohse. Proc Natl Acad Sci U S A 93(5):2105-9 (March 1996)Winstel, R Freund, S Krasel, C Hoppe, E Lohse, M J Research Support, Non-U.S. Gov't United states Proceedings of the National Academy of Sciences of the United States of America Proc Natl Acad Sci U S A. 1996 Mar 5;935:2105-9..
R. Winstel, S. Freund, C. Krasel, E. Hoppe, and M. J. Lohse. Proc Natl Acad Sci U S A 93(5):2105-9 (March 1996)Winstel, R Freund, S Krasel, C Hoppe, E Lohse, M J Research Support, Non-U.S. Gov't United states Proceedings of the National Academy of Sciences of the United States of America Proc Natl Acad Sci U S A. 1996 Mar 5;935:2105-9..
2 years and 6 months ago
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AMP-Dependent Acid Activation/drug Amino Animals C/*physiology CHO Cell Compartmentation Cricetinae Cyclic Data Enzyme Epinephrine/pharmacology Humans Kinase Kinases Kinases/*metabolism Line Membrane/enzymology Molecular Peptides/chemistry Phosphorylation Protein Proteins Receptor Recombinant Sequence Signal Transduction alpha-1/*metabolism beta-Adrenergic effects Adrenergic
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Pharmacological characterization of the adenylate cyclase-coupled adenosine receptor in isolated guinea pig atrial myocytes
A. Wilken, H. Tawfik-Schlieper, K. N. Klotz, and U. Schwabe. Mol Pharmacol 37(6):916-20 (June 1990)Wilken, A Tawfik-Schlieper, H Klotz, K N Schwabe, U Research Support, Non-U.S. Gov't United states Molecular pharmacology Mol Pharmacol. 1990 Jun;376:916-20..
A. Wilken, H. Tawfik-Schlieper, K. N. Klotz, and U. Schwabe. Mol Pharmacol 37(6):916-20 (June 1990)Wilken, A Tawfik-Schlieper, H Klotz, K N Schwabe, U Research Support, Non-U.S. Gov't United states Molecular pharmacology Mol Pharmacol. 1990 Jun;376:916-20..
2 years and 6 months ago
by pharmawuerz
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& *Cyclic 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone/pharmacology AMP AMP/metabolism Adenosine/analogs Adenylate Animals Atria/*metabolism Bordetella/pharmacology Carrier Cyclase Cyclase/*metabolism Cyclic Factors, Female Guinea Heart Isoproterenol/pharmacology Male Myocardium/cytology/*metabolism Pertussis Pigs Protein Proteins/drug Receptor Toxin Virulence derivatives/pharmacology effects/*metabolism
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Dobutamine-stress magnetic resonance microimaging in mice : acute changes of cardiac geometry and function in normal and failing murine hearts
F. Wiesmann, J. Ruff, S. Engelhardt, L. Hein, C. Dienesch, A. Leupold, R. Illinger, A. Frydrychowicz, K. H. Hiller, E. Rommel, A. Haase, M. J. Lohse, and S. Neubauer. Circ Res 88(6):563-9 (March 2001)Wiesmann, F Ruff, J Engelhardt, S Hein, L Dienesch, C Leupold, A Illinger, R Frydrychowicz, A Hiller, K H Rommel, E Haase, A Lohse, M J Neubauer, S Research Support, Non-U.S. Gov't United States Circulation research Circ Res. 2001 Mar 30;886:563-9..
F. Wiesmann, J. Ruff, S. Engelhardt, L. Hein, C. Dienesch, A. Leupold, R. Illinger, A. Frydrychowicz, K. H. Hiller, E. Rommel, A. Haase, M. J. Lohse, and S. Neubauer. Circ Res 88(6):563-9 (March 2001)Wiesmann, F Ruff, J Engelhardt, S Hein, L Dienesch, C Leupold, A Illinger, R Frydrychowicz, A Hiller, K H Rommel, E Haase, A Lohse, M J Neubauer, S Research Support, Non-U.S. Gov't United States Circulation research Circ Res. 2001 Mar 30;886:563-9..
2 years and 6 months ago
by pharmawuerz
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*Magnetic Adrenergic Animals Blood C57BL Contraction/drug Dobutamine/*pharmacology Female Function Function, Heart Imaging Infarction/physiopathology Injections, Intraperitoneal Left/drug Male Mice Myocardial Pressure/drug Resonance Stroke Transgenic Ventricles/*drug Ventricular Volume/drug beta-1/genetics/metabolism beta-Agonists/*pharmacology effects effects/physiology effects/physiopathology Receptor
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Involvement of Asn-293 in stereospecific agonist recognition and in activation of the beta 2-adrenergic receptor
K. Wieland, H. M. Zuurmond, C. Krasel, A. P. Ijzerman, and M. J. Lohse. Proc Natl Acad Sci U S A 93(17):9276-81 (August 1996)Wieland, K Zuurmond, H M Krasel, C Ijzerman, A P Lohse, M J Comparative Study Research Support, Non-U.S. Gov't United states Proceedings of the National Academy of Sciences of the United States of America Proc Natl Acad Sci U S A. 1996 Aug 20;9317:9276-81..
K. Wieland, H. M. Zuurmond, C. Krasel, A. P. Ijzerman, and M. J. Lohse. Proc Natl Acad Sci U S A 93(17):9276-81 (August 1996)Wieland, K Zuurmond, H M Krasel, C Ijzerman, A P Lohse, M J Comparative Study Research Support, Non-U.S. Gov't United states Proceedings of the National Academy of Sciences of the United States of America Proc Natl Acad Sci U S A. 1996 Aug 20;9317:9276-81..
2 years and 6 months ago
by pharmawuerz
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Adenylate Adrenergic Alprenolol/metabolism Animals Asparagine/genetics/metabolism Binding CHO Computer Cricetinae Cyclase/drug Humans Isoproterenol/chemistry/*metabolism/pharmacology Metoprolol/metabolism Models, Molecular Mutagenesis, Mutation Propranolol/metabolism Serine/genetics/metabolism Signal Simulation Site-Directed Sites Stereoisomerism Transduction beta-2/agonists/genetics/*metabolism beta-Agonists/*metabolism effects Receptor Cell
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Improving potency, selectivity, and water solubility of adenosine A1 receptor antagonists: xanthines modified at position 3 and related pyrimido1,2,3-cdpurinediones
S. Weyler, F. Fulle, M. Diekmann, B. Schumacher, S. Hinz, K. N. Klotz, and C. E. Muller. ChemMedChem 1(8):891-902 (August 2006)Weyler, Stefanie Fulle, Friederike Diekmann, Martina Schumacher, Britta Hinz, Sonja Klotz, Karl-Norbert Muller, Christa E Research Support, Non-U.S. Gov't Germany ChemMedChem ChemMedChem. 2006 Aug;18:891-902..
S. Weyler, F. Fulle, M. Diekmann, B. Schumacher, S. Hinz, K. N. Klotz, and C. E. Muller. ChemMedChem 1(8):891-902 (August 2006)Weyler, Stefanie Fulle, Friederike Diekmann, Martina Schumacher, Britta Hinz, Sonja Klotz, Karl-Norbert Muller, Christa E Research Support, Non-U.S. Gov't Germany ChemMedChem ChemMedChem. 2006 Aug;18:891-902..
2 years and 6 months ago
by pharmawuerz
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& A1/*antagonists Adamantane/*analogs Adenosine Animals Cultured Humans Phosphates/chemistry Prodrugs/chemistry/*pharmacology Rats Relationship Solubility Structure-Activity Water/chemistry Xanthine/*chemistry Xanthines/chemistry/*pharmacology derivatives/chemistry/pharmacology inhibitors Receptor Cell
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Overexpressed A1 adenosine receptors reduce activation of acetylcholine-sensitive K+ current by native muscarinic M2 receptors in rat atrial myocytes
M. C. Wellner-Kienitz, K. Bender, T. Meyer, M. Bunemann, and L. Pott. Circ Res 86(6):643-8 (March 2000)Wellner-Kienitz, M C Bender, K Meyer, T Bunemann, M Pott, L Research Support, Non-U.S. Gov't United states Circulation research Circ Res. 2000 Mar 31;866:643-8..
M. C. Wellner-Kienitz, K. Bender, T. Meyer, M. Bunemann, and L. Pott. Circ Res 86(6):643-8 (March 2000)Wellner-Kienitz, M C Bender, K Meyer, T Bunemann, M Pott, L Research Support, Non-U.S. Gov't United states Circulation research Circ Res. 2000 Mar 31;866:643-8..
2 years and 6 months ago
by pharmawuerz
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Acetylcholine/pharmacology/*physiology Adenosine/pharmacology Animals Atria Channels/drug Conductivity Electric Female Heart M2 Male Muscarinic Muscarinic/*physiology Myocardium/cytology/*metabolism P1/*metabolism Potassium Purinergic Rats Transfection WKY effects/*physiology Receptor Mice
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Autoradiographic visualization of A1-adenosine receptors in brain and peripheral tissues of rat and guinea pig using 125I-HPIA
R. G. Weber, C. R. Jones, J. M. Palacios, and M. J. Lohse. Neurosci Lett 87(3):215-20 (May 1988)Weber, R G Jones, C R Palacios, J M Lohse, M J Research Support, Non-U.S. Gov't Netherlands Neuroscience letters Neurosci Lett. 1988 May 3;873:215-20..
R. G. Weber, C. R. Jones, J. M. Palacios, and M. J. Lohse. Neurosci Lett 87(3):215-20 (May 1988)Weber, R G Jones, C R Palacios, J M Lohse, M J Research Support, Non-U.S. Gov't Netherlands Neuroscience letters Neurosci Lett. 1988 May 3;873:215-20..
2 years and 6 months ago
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& Adenosine/*analogs Animals Autoradiography Binding Brain/*metabolism Fractions/metabolism Guinea Male Phenylisopropyladenosine/*analogs Pigs Purinergic/*analysis Rats Sites Strains Subcellular derivatives/metabolism Receptor Mice
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Autoradiographic visualization of A1 adenosine receptors in rat brain with 3H8-cyclopentyl-1,3-dipropylxanthine
R. G. Weber, C. R. Jones, M. J. Lohse, and J. M. Palacios. J Neurochem 54(4):1344-53 (April 1990)Weber, R G Jones, C R Lohse, M J Palacios, J M Research Support, Non-U.S. Gov't United states Journal of neurochemistry J Neurochem. 1990 Apr;544:1344-53..
R. G. Weber, C. R. Jones, M. J. Lohse, and J. M. Palacios. J Neurochem 54(4):1344-53 (April 1990)Weber, R G Jones, C R Lohse, M J Palacios, J M Research Support, Non-U.S. Gov't United states Journal of neurochemistry J Neurochem. 1990 Apr;544:1344-53..
2 years and 6 months ago
by pharmawuerz
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Animals Autoradiography Binding Binding, Brain/*metabolism Competitive Factors Guanosine Male Phenylisopropyladenosine/metabolism Purinergic/*metabolism Rats Sites Strains Time Triphosphate/pharmacology Tritium/diagnostic Xanthines/*diagnostic use use/metabolism Receptor Mice
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cAMP microdomains and L-type Ca2+ channel regulation in guinea-pig ventricular myocytes
S. Warrier, G. Ramamurthy, R. L. Eckert, V. O. Nikolaev, M. J. Lohse, and R. D. Harvey. J Physiol 580(Pt.3):765-76 (May 2007)Warrier, Sunita Ramamurthy, Gopalakrishnan Eckert, Richard L Nikolaev, Viacheslav O Lohse, Martin J Harvey, Robert D Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't England The Journal of physiology J Physiol. 2007 May 1;580Pt.3:765-76. Epub 2007 Feb 8..
S. Warrier, G. Ramamurthy, R. L. Eckert, V. O. Nikolaev, M. J. Lohse, and R. D. Harvey. J Physiol 580(Pt.3):765-76 (May 2007)Warrier, Sunita Ramamurthy, Gopalakrishnan Eckert, Richard L Nikolaev, Viacheslav O Lohse, Martin J Harvey, Robert D Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't England The Journal of physiology J Physiol. 2007 May 1;580Pt.3:765-76. Epub 2007 Feb 8..
2 years and 6 months ago
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AMP/*physiology Adrenergic Alprostadil/pharmacology Animals Calcium Cardiac/*metabolism Caveolae/metabolism Channels, Cultured Cyclic Cytosol/metabolism Diester Distribution/drug GTP-Binding Gi-Go/physiology Guinea Heart Hydrolases/metabolism Isoproterenol/pharmacology L-Type/drug Myocytes, Phosphoric Pigs Prostaglandin/metabolism Protein Structure, Subunits, Tertiary Tissue Ventricles alpha beta-Agonists/pharmacology effects effects/*metabolism Receptor Cell
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N6-methoxy-2-alkynyladenosine derivatives as highly potent and selective ligands at the human A3 adenosine receptor
R. Volpini, D. Dal Ben, C. Lambertucci, S. Taffi, S. Vittori, K. N. Klotz, and G. Cristalli. J Med Chem 50(6):1222-30 (March 2007)Volpini, Rosaria Dal Ben, Diego Lambertucci, Catia Taffi, Sara Vittori, Sauro Klotz, Karl-Norbert Cristalli, Gloria Research Support, Non-U.S. Gov't United States Journal of medicinal chemistry J Med Chem. 2007 Mar 22;506:1222-30. Epub 2007 Feb 20..
R. Volpini, D. Dal Ben, C. Lambertucci, S. Taffi, S. Vittori, K. N. Klotz, and G. Cristalli. J Med Chem 50(6):1222-30 (March 2007)Volpini, Rosaria Dal Ben, Diego Lambertucci, Catia Taffi, Sara Vittori, Sauro Klotz, Karl-Norbert Cristalli, Gloria Research Support, Non-U.S. Gov't United States Journal of medicinal chemistry J Med Chem. 2007 Mar 22;506:1222-30. Epub 2007 Feb 20..
2 years and 6 months ago
by pharmawuerz
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& *Models, A3/*agonists AMP/biosynthesis Acid Adenosine Adenosine/*analogs Alkynes/*chemical Amino Animals Assay CHO Cricetinae Cricetulus Cyclic Homology, Humans Ligands Molecular Proteins/agonists Radioligand Recombinant Relationship Rhodopsin/chemistry Sequence Structure-Activity derivatives/*chemical synthesis/chemistry/pharmacology Receptor Cell
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Adenosine A2A receptor antagonists: new 8-substituted 9-ethyladenines as tools for in vivo rat models of Parkinson's disease
R. Volpini, D. Dal Ben, C. Lambertucci, G. Marucci, R. C. Mishra, A. T. Ramadori, K. N. Klotz, M. L. Trincavelli, C. Martini, and G. Cristalli. ChemMedChem 4(6):1010-9 (June 2009)Volpini, Rosaria Dal Ben, Diego Lambertucci, Catia Marucci, Gabriella Mishra, Ram Chandra Ramadori, Anna Teresa Klotz, Karl-Norbert Trincavelli, Maria Letizia Martini, Claudia Cristalli, Gloria Research Support, Non-U.S. Gov't Germany ChemMedChem ChemMedChem. 2009 Jun;46:1010-9..
R. Volpini, D. Dal Ben, C. Lambertucci, G. Marucci, R. C. Mishra, A. T. Ramadori, K. N. Klotz, M. L. Trincavelli, C. Martini, and G. Cristalli. ChemMedChem 4(6):1010-9 (June 2009)Volpini, Rosaria Dal Ben, Diego Lambertucci, Catia Marucci, Gabriella Mishra, Ram Chandra Ramadori, Anna Teresa Klotz, Karl-Norbert Trincavelli, Maria Letizia Martini, Claudia Cristalli, Gloria Research Support, Non-U.S. Gov't Germany ChemMedChem ChemMedChem. 2009 Jun;46:1010-9..
2 years and 6 months ago
by pharmawuerz
2
& A2A/*antagonists Adenine/*analogs Adenosine Animal Animals Binding Chemical Computer Crystallography, Disease Disease/*drug Humans Models, Parkinson Protein Rats Simulation Sites X-Ray derivatives/chemical inhibitors/metabolism synthesis/pharmacology therapy Receptor
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Medicinal chemistry and pharmacology of A2B adenosine receptors
R. Volpini, S. Costanzi, S. Vittori, G. Cristalli, and K. N. Klotz. Curr Top Med Chem 3(4):427-43 (2003)Volpini, Rosaria Costanzi, Stefano Vittori, Sauro Cristalli, Gloria Klotz, Karl-Norbert Research Support, Non-U.S. Gov't Netherlands Current topics in medicinal chemistry Curr Top Med Chem. 2003;34:427-43..
R. Volpini, S. Costanzi, S. Vittori, G. Cristalli, and K. N. Klotz. Curr Top Med Chem 3(4):427-43 (2003)Volpini, Rosaria Costanzi, Stefano Vittori, Sauro Cristalli, Gloria Klotz, Karl-Norbert Research Support, Non-U.S. Gov't Netherlands Current topics in medicinal chemistry Curr Top Med Chem. 2003;34:427-43..
2 years and 6 months ago
by pharmawuerz
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& *Drug *Receptors, A2B Adenine/analogs Adenosine Adenosine/analogs Animals Data Design Homology Humans Molecular P1/agonists/antagonists Purinergic Relationship Sequence Structure-Activity Xanthines/chemistry/*pharmacology derivatives/*pharmacology inhibitors/chemistry Receptor
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N6-alkyl-2-alkynyl derivatives of adenosine as potent and selective agonists at the human adenosine A3 receptor and a starting point for searching A2B ligands
R. Volpini, S. Costanzi, C. Lambertucci, S. Taffi, S. Vittori, K. N. Klotz, and G. Cristalli. J Med Chem 45(15):3271-9 (July 2002)Volpini, Rosaria Costanzi, Stefano Lambertucci, Catia Taffi, Sara Vittori, Sauro Klotz, Karl-Norbert Cristalli, Gloria Research Support, Non-U.S. Gov't United States Journal of medicinal chemistry J Med Chem. 2002 Jul 18;4515:3271-9..
R. Volpini, S. Costanzi, C. Lambertucci, S. Taffi, S. Vittori, K. N. Klotz, and G. Cristalli. J Med Chem 45(15):3271-9 (July 2002)Volpini, Rosaria Costanzi, Stefano Lambertucci, Catia Taffi, Sara Vittori, Sauro Klotz, Karl-Norbert Cristalli, Gloria Research Support, Non-U.S. Gov't United States Journal of medicinal chemistry J Med Chem. 2002 Jul 18;4515:3271-9..
2 years and 6 months ago
by pharmawuerz
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& A2A A2B A3 Adenosine Adenosine/*analogs Adenylate Alkynes/*chemical Animals CHO Cricetinae Cyclase/metabolism Humans Ligands Magnetic P1/*agonists/metabolism Proteins/metabolism Purinergic Recombinant Relationship Resonance Spectroscopy Stereoisomerism Structure-Activity derivatives/*chemical synthesis/chemistry/pharmacology Receptor Cell
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Synthesis of di- and tri-substituted adenosine derivatives and their affinities at human adenosine receptor subtypes
R. Volpini, E. Camaioni, S. Costanzi, S. Vittori, K. N. Klotz, and G. Cristalli. Nucleosides Nucleotides 18(11-12):2511-20 (November 1999)Volpini, R Camaioni, E Costanzi, S Vittori, S Klotz, K N Cristalli, G Comparative Study Research Support, Non-U.S. Gov't United states Nucleosides \& nucleotides Nucleosides Nucleotides. 1999 Nov-Dec;1811-12:2511-20..
R. Volpini, E. Camaioni, S. Costanzi, S. Vittori, K. N. Klotz, and G. Cristalli. Nucleosides Nucleotides 18(11-12):2511-20 (November 1999)Volpini, R Camaioni, E Costanzi, S Vittori, S Klotz, K N Cristalli, G Comparative Study Research Support, Non-U.S. Gov't United states Nucleosides \& nucleotides Nucleosides Nucleotides. 1999 Nov-Dec;1811-12:2511-20..
2 years and 6 months ago
by pharmawuerz
2
& A2A A2B A3 Activation/drug Adenosine Adenosine/*analogs Adenylate Animals Assay CHO Cricetinae Cricetulus Cyclase/metabolism Enzyme Fusion Humans P1/*drug Proteins/drug Purinergic Radioligand Rats Recombinant Transfection derivatives/chemical effects effects/genetics synthesis/pharmacology Receptor Cell
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URLDOITeX
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