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A new synthesis of sulfonamides by aminolysis of p-nitrophenylsulfonates yielding potent and selective adenosine A2B receptor antagonists
L. Yan, D. C. Bertarelli, A. M. Hayallah, H. Meyer, K. N. Klotz, and C. E. Muller. J Med Chem 49(14):4384-91 (July 2006)Yan, Luo Bertarelli, Daniela C G Hayallah, Alaa M Meyer, Heiko Klotz, Karl-Norbert Muller, Christa E In Vitro Research Support, Non-U.S. Gov't United States Journal of medicinal chemistry J Med Chem. 2006 Jul 13;4914:4384-91..
L. Yan, D. C. Bertarelli, A. M. Hayallah, H. Meyer, K. N. Klotz, and C. E. Muller. J Med Chem 49(14):4384-91 (July 2006)Yan, Luo Bertarelli, Daniela C G Hayallah, Alaa M Meyer, Heiko Klotz, Karl-Norbert Muller, Christa E In Vitro Research Support, Non-U.S. Gov't United States Journal of medicinal chemistry J Med Chem. 2006 Jul 13;4914:4384-91..
2 years and 6 months ago
by pharmawuerz
1
& A2B/*antagonists Adenosine Animals Arylsulfonates/*chemistry Assay Brain/metabolism CHO Cricetinae Cricetulus Humans Proteins/antagonists Radioligand Rats Recombinant Relationship Structure-Activity Sulfonamides/*chemical Xanthines/*chemical inhibitors synthesis/chemistry/pharmacology Receptor Cell
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The galanin receptor type 2 initiates multiple signaling pathways in small cell lung cancer cells by coupling to Gq, Gi and G12 proteins
N. Wittau, R. Grosse, F. Kalkbrenner, A. Gohla, G. Schultz, and T. Gudermann. Oncogene 19(37):4199-209 (August 2000)Wittau, N Grosse, R Kalkbrenner, F Gohla, A Schultz, G Gudermann, T England Oncogene Oncogene. 2000 Aug 31;1937:4199-209..
N. Wittau, R. Grosse, F. Kalkbrenner, A. Gohla, G. Schultz, and T. Gudermann. Oncogene 19(37):4199-209 (August 2000)Wittau, N Grosse, R Kalkbrenner, F Gohla, A Schultz, G Gudermann, T England Oncogene Oncogene. 2000 Aug 31;1937:4199-209..
2 years and 6 months ago
by pharmawuerz
2
& 1-Methyl-3-isobutylxanthine/pharmacology 1/metabolism 2 3 3T3 AMP/physiology Actins/metabolism Adhesion Animals Bordetella/pharmacology C C/antagonists COS Calcium Carcinoma, Cell Cell/metabolism/*pathology Cells/drug Cultured/metabolism Cyclic Diacylglycerol-Lyase Enzyme Factors, Fusion G12-G13 GTP-Binding Galanin Galanin, Galanin/metabolism/pharmacology Gi-Go/*physiology Gohla Gq-G11 Heterotrimeric Humans Indoles/pharmacology Inhibitors/pharmacology Inositol Intracellular Isoproterenol/pharmacology Kinase Kinases Kinases/metabolism Kinases/physiology Lung Maleimides/pharmacology Mice Microfilaments/metabolism Mitogen-Activated Neoplasm Neoplasms/metabolism/*pathology Neuropeptide/drug Peptides Pertussis Phosphates/metabolism Phosphatidylinositol Phospholipases/metabolism Protein Protein-Serine-Threonine Protein/physiology Proteins Proteins/*physiology Proteins/antagonists Proteins/genetics/physiology Recombinant Signaling Signaling/drug Small Subunits, Toxin Transfection Tumor Type Virulence alpha and effects effects/*physiology inhibitors/*physiology inhibitors/physiology rho-Associated rhoA Receptor
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URLDOITeX
Protein kinase cross-talk: membrane targeting of the beta-adrenergic receptor kinase by protein kinase C
R. Winstel, S. Freund, C. Krasel, E. Hoppe, and M. J. Lohse. Proc Natl Acad Sci U S A 93(5):2105-9 (March 1996)Winstel, R Freund, S Krasel, C Hoppe, E Lohse, M J Research Support, Non-U.S. Gov't United states Proceedings of the National Academy of Sciences of the United States of America Proc Natl Acad Sci U S A. 1996 Mar 5;935:2105-9..
R. Winstel, S. Freund, C. Krasel, E. Hoppe, and M. J. Lohse. Proc Natl Acad Sci U S A 93(5):2105-9 (March 1996)Winstel, R Freund, S Krasel, C Hoppe, E Lohse, M J Research Support, Non-U.S. Gov't United states Proceedings of the National Academy of Sciences of the United States of America Proc Natl Acad Sci U S A. 1996 Mar 5;935:2105-9..
2 years and 6 months ago
by pharmawuerz
2
AMP-Dependent Acid Activation/drug Amino Animals C/*physiology CHO Cell Compartmentation Cricetinae Cyclic Data Enzyme Epinephrine/pharmacology Humans Kinase Kinases Kinases/*metabolism Line Membrane/enzymology Molecular Peptides/chemistry Phosphorylation Protein Proteins Receptor Recombinant Sequence Signal Transduction alpha-1/*metabolism beta-Adrenergic effects Adrenergic
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N6-methoxy-2-alkynyladenosine derivatives as highly potent and selective ligands at the human A3 adenosine receptor
R. Volpini, D. Dal Ben, C. Lambertucci, S. Taffi, S. Vittori, K. N. Klotz, and G. Cristalli. J Med Chem 50(6):1222-30 (March 2007)Volpini, Rosaria Dal Ben, Diego Lambertucci, Catia Taffi, Sara Vittori, Sauro Klotz, Karl-Norbert Cristalli, Gloria Research Support, Non-U.S. Gov't United States Journal of medicinal chemistry J Med Chem. 2007 Mar 22;506:1222-30. Epub 2007 Feb 20..
R. Volpini, D. Dal Ben, C. Lambertucci, S. Taffi, S. Vittori, K. N. Klotz, and G. Cristalli. J Med Chem 50(6):1222-30 (March 2007)Volpini, Rosaria Dal Ben, Diego Lambertucci, Catia Taffi, Sara Vittori, Sauro Klotz, Karl-Norbert Cristalli, Gloria Research Support, Non-U.S. Gov't United States Journal of medicinal chemistry J Med Chem. 2007 Mar 22;506:1222-30. Epub 2007 Feb 20..
2 years and 6 months ago
by pharmawuerz
2
& *Models, A3/*agonists AMP/biosynthesis Acid Adenosine Adenosine/*analogs Alkynes/*chemical Amino Animals Assay CHO Cricetinae Cricetulus Cyclic Homology, Humans Ligands Molecular Proteins/agonists Radioligand Recombinant Relationship Rhodopsin/chemistry Sequence Structure-Activity derivatives/*chemical synthesis/chemistry/pharmacology Receptor Cell
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N6-alkyl-2-alkynyl derivatives of adenosine as potent and selective agonists at the human adenosine A3 receptor and a starting point for searching A2B ligands
R. Volpini, S. Costanzi, C. Lambertucci, S. Taffi, S. Vittori, K. N. Klotz, and G. Cristalli. J Med Chem 45(15):3271-9 (July 2002)Volpini, Rosaria Costanzi, Stefano Lambertucci, Catia Taffi, Sara Vittori, Sauro Klotz, Karl-Norbert Cristalli, Gloria Research Support, Non-U.S. Gov't United States Journal of medicinal chemistry J Med Chem. 2002 Jul 18;4515:3271-9..
R. Volpini, S. Costanzi, C. Lambertucci, S. Taffi, S. Vittori, K. N. Klotz, and G. Cristalli. J Med Chem 45(15):3271-9 (July 2002)Volpini, Rosaria Costanzi, Stefano Lambertucci, Catia Taffi, Sara Vittori, Sauro Klotz, Karl-Norbert Cristalli, Gloria Research Support, Non-U.S. Gov't United States Journal of medicinal chemistry J Med Chem. 2002 Jul 18;4515:3271-9..
2 years and 6 months ago
by pharmawuerz
2
& A2A A2B A3 Adenosine Adenosine/*analogs Adenylate Alkynes/*chemical Animals CHO Cricetinae Cyclase/metabolism Humans Ligands Magnetic P1/*agonists/metabolism Proteins/metabolism Purinergic Recombinant Relationship Resonance Spectroscopy Stereoisomerism Structure-Activity derivatives/*chemical synthesis/chemistry/pharmacology Receptor Cell
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Synthesis of di- and tri-substituted adenosine derivatives and their affinities at human adenosine receptor subtypes
R. Volpini, E. Camaioni, S. Costanzi, S. Vittori, K. N. Klotz, and G. Cristalli. Nucleosides Nucleotides 18(11-12):2511-20 (November 1999)Volpini, R Camaioni, E Costanzi, S Vittori, S Klotz, K N Cristalli, G Comparative Study Research Support, Non-U.S. Gov't United states Nucleosides \& nucleotides Nucleosides Nucleotides. 1999 Nov-Dec;1811-12:2511-20..
R. Volpini, E. Camaioni, S. Costanzi, S. Vittori, K. N. Klotz, and G. Cristalli. Nucleosides Nucleotides 18(11-12):2511-20 (November 1999)Volpini, R Camaioni, E Costanzi, S Vittori, S Klotz, K N Cristalli, G Comparative Study Research Support, Non-U.S. Gov't United states Nucleosides \& nucleotides Nucleosides Nucleotides. 1999 Nov-Dec;1811-12:2511-20..
2 years and 6 months ago
by pharmawuerz
2
& A2A A2B A3 Activation/drug Adenosine Adenosine/*analogs Adenylate Animals Assay CHO Cricetinae Cricetulus Cyclase/metabolism Enzyme Fusion Humans P1/*drug Proteins/drug Purinergic Radioligand Rats Recombinant Transfection derivatives/chemical effects effects/genetics synthesis/pharmacology Receptor Cell
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URLDOITeX
Synthesis and receptor affinity of polysubstituted adenosines
S. Vittori, E. Camaioni, S. Costanzi, R. Volpini, K. N. Klotz, and G. Cristalli. Nucleosides Nucleotides 18(4-5):739-40 (April 1999)Vittori, S Camaioni, E Costanzi, S Volpini, R Klotz, K N Cristalli, G United states Nucleosides \& nucleotides Nucleosides Nucleotides. 1999 Apr-May;184-5:739-40..
S. Vittori, E. Camaioni, S. Costanzi, R. Volpini, K. N. Klotz, and G. Cristalli. Nucleosides Nucleotides 18(4-5):739-40 (April 1999)Vittori, S Camaioni, E Costanzi, S Volpini, R Klotz, K N Cristalli, G United states Nucleosides \& nucleotides Nucleosides Nucleotides. 1999 Apr-May;184-5:739-40..
2 years and 6 months ago
by pharmawuerz
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& Adenosine/*analogs Animals Binding CHO Cricetinae Humans P1/*metabolism Protein Proteins/metabolism Purinergic Rats Recombinant derivatives/chemical synthesis/metabolism Receptor Cell
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Pharmacological characterization of novel adenosine ligands in recombinant and native human A2B receptors
K. Varani, S. Gessi, S. Merighi, F. Vincenzi, E. Cattabriga, A. Benini, K. N. Klotz, P. G. Baraldi, M. A. Tabrizi, S. M. Lennan, E. Leung, and P. A. Borea. Biochem Pharmacol 70(11):1601-12 (November 2005)Varani, Katia Gessi, Stefania Merighi, Stefania Vincenzi, Fabrizio Cattabriga, Elena Benini, Annalisa Klotz, Karl-Norbert Baraldi, Pier Giovanni Tabrizi, Mojgan Aghazadeh Lennan, Stephen Mac Leung, Edward Borea, Pier Andrea England Biochemical pharmacology Biochem Pharmacol. 2005 Nov 25;7011:1601-12. Epub 2005 Oct 10..
K. Varani, S. Gessi, S. Merighi, F. Vincenzi, E. Cattabriga, A. Benini, K. N. Klotz, P. G. Baraldi, M. A. Tabrizi, S. M. Lennan, E. Leung, and P. A. Borea. Biochem Pharmacol 70(11):1601-12 (November 2005)Varani, Katia Gessi, Stefania Merighi, Stefania Vincenzi, Fabrizio Cattabriga, Elena Benini, Annalisa Klotz, Karl-Norbert Baraldi, Pier Giovanni Tabrizi, Mojgan Aghazadeh Lennan, Stephen Mac Leung, Edward Borea, Pier Andrea England Biochemical pharmacology Biochem Pharmacol. 2005 Nov 25;7011:1601-12. Epub 2005 Oct 10..
2 years and 6 months ago
by pharmawuerz
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& A2B/antagonists AMP/metabolism Adenosine Adenosine/chemistry/*metabolism/*pharmacology Animals Binding Binding, Cell Competitive Cyclic Humans Line Molecular Protein Proteins Recombinant Structure inhibitors/genetics/*metabolism Receptor
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Breakdown of axonal synaptic vesicle precursor transport by microglial nitric oxide
M. Stagi, P. S. Dittrich, N. Frank, A. I. Iliev, P. Schwille, and H. Neumann. J Neurosci 25(2):352-62 (January 2005)Stagi, Massimiliano Dittrich, Petra S Frank, Nadja Iliev, Asparouh I Schwille, Petra Neumann, Harald Research Support, Non-U.S. Gov't United States The Journal of neuroscience : the official journal of the Society for Neuroscience J Neurosci. 2005 Jan 12;252:352-62..
M. Stagi, P. S. Dittrich, N. Frank, A. I. Iliev, P. Schwille, and H. Neumann. J Neurosci 25(2):352-62 (January 2005)Stagi, Massimiliano Dittrich, Petra S Frank, Nadja Iliev, Asparouh I Schwille, Petra Neumann, Harald Research Support, Non-U.S. Gov't United States The Journal of neuroscience : the official journal of the Society for Neuroscience J Neurosci. 2005 Jan 12;252:352-62..
2 years and 6 months ago
by pharmawuerz
1
Animals Axonal C57BL Calcium-Binding Cultured Fluorescent Fusion Glycoproteins/metabolism Green Hippocampus/cytology/metabolism I Inflammation/metabolism JNK Kinases/metabolism Membrane Mice Microglia/*metabolism Mitogen-Activated Nerve Nitric Oxide/*physiology Protein Proteins/metabolism Recombinant Synaptic Synaptophysin/metabolism Synaptotagmin Synaptotagmins Tissue Transport/*physiology Vesicles/*metabolism Cell
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Expression of beta 2-adrenoceptors in halobacteria
P. Sohlemann, J. Soppa, D. Oesterhelt, and M. J. Lohse. Naunyn Schmiedebergs Arch Pharmacol 355(2):150-60 (February 1997)Sohlemann, P Soppa, J Oesterhelt, D Lohse, M J Comparative Study Research Support, Non-U.S. Gov't Germany Naunyn-Schmiedeberg's archives of pharmacology Naunyn Schmiedebergs Arch Pharmacol. 1997 Feb;3552:150-60..
P. Sohlemann, J. Soppa, D. Oesterhelt, and M. J. Lohse. Naunyn Schmiedebergs Arch Pharmacol 355(2):150-60 (February 1997)Sohlemann, P Soppa, J Oesterhelt, D Lohse, M J Comparative Study Research Support, Non-U.S. Gov't Germany Naunyn-Schmiedeberg's archives of pharmacology Naunyn Schmiedebergs Arch Pharmacol. 1997 Feb;3552:150-60..
2 years and 6 months ago
by pharmawuerz
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& Adrenergic Animals Antagonists/metabolism Bacteriorhodopsins/genetics Blotting, Chain Genetic Halobacterium/*genetics Humans Northern Pindolol/analogs Polymerase Proteins/biosynthesis/metabolism Reaction Recombinant Vectors/genetics Western beta-2/*biosynthesis/metabolism derivatives/metabolism Receptor
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Binding of purified recombinant beta-arrestin to guanine-nucleotide-binding-protein-coupled receptors
P. Sohlemann, M. Hekman, M. Puzicha, C. Buchen, and M. J. Lohse. Eur J Biochem 232(2):464-72 (September 1995)Sohlemann, P Hekman, M Puzicha, M Buchen, C Lohse, M J Research Support, Non-U.S. Gov't Germany European journal of biochemistry / FEBS Eur J Biochem. 1995 Sep 1;2322:464-72..
P. Sohlemann, M. Hekman, M. Puzicha, C. Buchen, and M. J. Lohse. Eur J Biochem 232(2):464-72 (September 1995)Sohlemann, P Hekman, M Puzicha, M Buchen, C Lohse, M J Research Support, Non-U.S. Gov't Germany European journal of biochemistry / FEBS Eur J Biochem. 1995 Sep 1;2322:464-72..
2 years and 6 months ago
by pharmawuerz
1
*Arrestins AMP-Dependent Adenylate Animals Antigens/genetics/*metabolism Binding Cell Cyclase/metabolism Cyclic Expression Eye GTP-Binding Gene Humans Kinases Kinases/metabolism Kinetics Line Outer Phosphorylation Protein Proteins/genetics/*metabolism Proteins/genetics/metabolism Receptor Recombinant Rhodopsin/metabolism Rod Segment/metabolism Spodoptera beta-2/chemistry/genetics/*metabolism beta-Adrenergic Proteins/metabolism Adrenergic
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Purification and functional characterization of beta-adrenergic receptor kinase expressed in insect cells
P. Sohlemann, M. Hekman, C. Buchen, J. S. Elce, and M. J. Lohse. FEBS Lett 324(1):59-62 (June 1993)Sohlemann, P Hekman, M Buchen, C Elce, J S Lohse, M J Comparative Study Research Support, Non-U.S. Gov't Netherlands FEBS letters FEBS Lett. 1993 Jun 7;3241:59-62..
P. Sohlemann, M. Hekman, C. Buchen, J. S. Elce, and M. J. Lohse. FEBS Lett 324(1):59-62 (June 1993)Sohlemann, P Hekman, M Buchen, C Elce, J S Lohse, M J Comparative Study Research Support, Non-U.S. Gov't Netherlands FEBS letters FEBS Lett. 1993 Jun 7;3241:59-62..
2 years and 6 months ago
by pharmawuerz
1
& *Cyclic AMP-Dependent Adenosine Animals Cell Chromatography, Cloning, Exchange Gel Humans Ion Kinases Kinases/genetics/*isolation Kinetics Line Molecular Moths Outer Phosphorylation Protein Proteins/isolation Receptor Recombinant Rhodopsin/metabolism Rod Segment/metabolism Transfection Triphosphate/metabolism beta-Adrenergic purification/*metabolism purification/metabolism
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Binding of Gbetagamma subunits to cRaf1 downregulates G-protein-coupled receptor signalling
J. R. Slupsky, U. Quitterer, C. K. Weber, P. Gierschik, M. J. Lohse, and U. R. Rapp. Curr Biol 9(17):971-4 (September 1999)Slupsky, J R Quitterer, U Weber, C K Gierschik, P Lohse, M J Rapp, U R Research Support, Non-U.S. Gov't England Current biology : CB Curr Biol. 1999 Sep 9;917:971-4..
J. R. Slupsky, U. Quitterer, C. K. Weber, P. Gierschik, M. J. Lohse, and U. R. Rapp. Curr Biol 9(17):971-4 (September 1999)Slupsky, J R Quitterer, U Weber, C K Gierschik, P Lohse, M J Rapp, U R Research Support, Non-U.S. Gov't England Current biology : CB Curr Biol. 1999 Sep 9;917:971-4..
2 years and 6 months ago
by pharmawuerz
1
Animals B2 Binding Bradykinin Bradykinin/genetics/physiology COS Cell Cercopithecus Fusion GTP-Binding Heterotrimeric Humans Kidney Kinase Line MAP Protein Proteins Proteins/physiology Proto-Oncogene Recombinant Signaling System/*physiology Transfection aethiops c-raf/*metabolism p21(ras)/physiology Receptor Proteins/metabolism
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Inhibition of G-protein betagamma-subunit functions by phosducin-like protein
S. Schroder, and M. J. Lohse. Proc Natl Acad Sci U S A 93(5):2100-4 (March 1996)Schroder, S Lohse, M J Research Support, Non-U.S. Gov't United states Proceedings of the National Academy of Sciences of the United States of America Proc Natl Acad Sci U S A. 1996 Mar 5;935:2100-4..
S. Schroder, and M. J. Lohse. Proc Natl Acad Sci U S A 93(5):2100-4 (March 1996)Schroder, S Lohse, M J Research Support, Non-U.S. Gov't United states Proceedings of the National Academy of Sciences of the United States of America Proc Natl Acad Sci U S A. 1996 Mar 5;935:2100-4..
2 years and 6 months ago
by pharmawuerz
1
& Alignment Animals Base Bordetella/antagonists Carrier DNA Data Enzyme Eye Factors, GTP GTP-Binding Inhibitors Molecular Nerve Pertussis Phosphohydrolases/antagonists Phosphoproteins/*chemistry Phosphorylation Primers/chemistry Protein Proteins Proteins/*antagonists Proteins/*chemistry Proteins/isolation Rats Recombinant Regulators Rhodopsin/metabolism Sequence Signal Tissue Toxin Transduction Virulence inhibitors purification/*metabolism
(0)
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Identification of a C-terminal binding site for G-protein betagamma-subunits in phosducin-like protein
S. Schroder, K. Bluml, C. Dees, and M. J. Lohse. FEBS Lett 401(2-3):243-6 (January 1997)Schroder, S Bluml, K Dees, C Lohse, M J Research Support, Non-U.S. Gov't Netherlands FEBS letters FEBS Lett. 1997 Jan 20;4012-3:243-6..
S. Schroder, K. Bluml, C. Dees, and M. J. Lohse. FEBS Lett 401(2-3):243-6 (January 1997)Schroder, S Bluml, K Dees, C Lohse, M J Research Support, Non-U.S. Gov't Netherlands FEBS letters FEBS Lett. 1997 Jan 20;4012-3:243-6..
2 years and 6 months ago
by pharmawuerz
1
& Animals Binding Carrier Deletion Escherichia Fusion GTP GTP-Binding Nerve Phosphohydrolases/antagonists Proteins/antagonists Proteins/genetics/*metabolism Proteins/genetics/metabolism Recombinant Sequence Sites Tissue coli inhibitors/*metabolism inhibitors/metabolism
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Receptor-ligand interactions studied with homogeneous fluorescence-based assays suitable for miniaturized screening
A. A. Scheel, B. Funsch, M. Busch, G. Gradl, J. Pschorr, and M. J. Lohse. J Biomol Screen 6(1):11-8 (February 2001)Scheel, A A Funsch, B Busch, M Gradl, G Pschorr, J Lohse, M J United States Journal of biomolecular screening : the official journal of the Society for Biomolecular Screening J Biomol Screen. 2001 Feb;61:11-8..
A. A. Scheel, B. Funsch, M. Busch, G. Gradl, J. Pschorr, and M. J. Lohse. J Biomol Screen 6(1):11-8 (February 2001)Scheel, A A Funsch, B Busch, M Gradl, G Pschorr, J Lohse, M J United States Journal of biomolecular screening : the official journal of the Society for Biomolecular Screening J Biomol Screen. 2001 Feb;61:11-8..
2 years and 6 months ago
by pharmawuerz
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& *Intercellular Cell Drug Dyes Epidermal Evaluation, Factor/analysis/metabolism Factor/metabolism Fluorescence Fluorescent Growth Humans Ligands Line Miniaturization Optics Peptides Photonics Preclinical/*methods/statistics Propanolamines/metabolism Propranolol/metabolism Proteins Proteins/analysis/genetics/metabolism Recombinant Sensitivity Signaling Specificity Substances/metabolism Surface/analysis/*metabolism and beta-2/analysis/genetics/metabolism data numerical Receptor Adrenergic
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Water-soluble phosphate prodrugs of 1-propargyl-8-styrylxanthine derivatives, A2A-selective adenosine receptor antagonists
R. Sauer, J. Maurinsh, U. Reith, F. Fulle, K. N. Klotz, and C. E. Muller. J Med Chem 43(3):440-8 (February 2000)Sauer, R Maurinsh, J Reith, U Fulle, F Klotz, K N Muller, C E In Vitro Research Support, Non-U.S. Gov't United states Journal of medicinal chemistry J Med Chem. 2000 Feb 10;433:440-8..
R. Sauer, J. Maurinsh, U. Reith, F. Fulle, K. N. Klotz, and C. E. Muller. J Med Chem 43(3):440-8 (February 2000)Sauer, R Maurinsh, J Reith, U Fulle, F Klotz, K N Muller, C E In Vitro Research Support, Non-U.S. Gov't United states Journal of medicinal chemistry J Med Chem. 2000 Feb 10;433:440-8..
2 years and 6 months ago
by pharmawuerz
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& A2A Adenosine Animals Assay CHO Caudate Cerebral Corpus Cortex/metabolism Cricetinae Humans Nucleus/metabolism P1/*antagonists Prodrugs/*chemical Proteins/antagonists Purinergic Radioligand Rats Recombinant Relationship Solubility Striatum/metabolism Structure-Activity Xanthines/*chemical inhibitors synthesis/chemistry/metabolism/pharmacology synthesis/chemistry/pharmacology Receptor Cell
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Real-time optical recording of beta1-adrenergic receptor activation reveals supersensitivity of the Arg389 variant to carvedilol
F. Rochais, J. P. Vilardaga, V. O. Nikolaev, M. Bunemann, M. J. Lohse, and S. Engelhardt. J Clin Invest 117(1):229-35 (January 2007)Rochais, Francesca Vilardaga, Jean-Pierre Nikolaev, Viacheslav O Bunemann, Moritz Lohse, Martin J Engelhardt, Stefan Research Support, Non-U.S. Gov't United States The Journal of clinical investigation J Clin Invest. 2007 Jan;1171:229-35..
F. Rochais, J. P. Vilardaga, V. O. Nikolaev, M. Bunemann, M. J. Lohse, and S. Engelhardt. J Clin Invest 117(1):229-35 (January 2007)Rochais, Francesca Vilardaga, Jean-Pierre Nikolaev, Viacheslav O Bunemann, Moritz Lohse, Martin J Engelhardt, Stefan Research Support, Non-U.S. Gov't United States The Journal of clinical investigation J Clin Invest. 2007 Jan;1171:229-35..
2 years and 6 months ago
by pharmawuerz
1
*Arginine *Genetic Acid Adrenergic Amino Base Carbazoles/*pharmacology Cell Energy Fluorescence Line Propanolamines/*pharmacology Proteins/drug Recombinant Resonance Sequence Substitution Transfection Transfer Variation beta-1/drug beta-Antagonists/*pharmacology effects/*genetics/*physiology effects/metabolism Receptor
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Crosstalk between Galphai- and Galphaq-coupled receptors is mediated by Gbetagamma exchange
U. Quitterer, and M. J. Lohse. Proc Natl Acad Sci U S A 96(19):10626-31 (September 1999)Quitterer, U Lohse, M J United states Proceedings of the National Academy of Sciences of the United States of America Proc Natl Acad Sci U S A. 1999 Sep 14;9619:10626-31..
U. Quitterer, and M. J. Lohse. Proc Natl Acad Sci U S A 96(19):10626-31 (September 1999)Quitterer, U Lohse, M J United states Proceedings of the National Academy of Sciences of the United States of America Proc Natl Acad Sci U S A. 1999 Sep 14;9619:10626-31..
2 years and 6 months ago
by pharmawuerz
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Animals B2 Biological Bradykinin Bradykinin/*metabolism C COS Calcium/metabolism Cross-Talk/*physiology Dose-Response Drug Factors Fusion GTP-Binding Immunoblotting Inositol Models, Mutagenesis Phosphates/metabolism Phospholipases/metabolism Proteins/metabolism Receptor Recombinant Relationship, Signal Time Transduction Transfection Triphosphate/metabolism Type Uridine beta-2/metabolism Cell Adrenergic
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Expression, purification, and characterization of the cGMP-dependent protein kinases I beta and II using the baculovirus system
D. Pohler, E. Butt, J. Meissner, S. Muller, M. Lohse, U. Walter, S. M. Lohmann, and T. Jarchau. FEBS Lett 374(3):419-25 (November 1995)Pohler, D Butt, E Meissner, J Muller, S Lohse, M Walter, U Lohmann, S M Jarchau, T Research Support, Non-U.S. Gov't Netherlands FEBS letters FEBS Lett. 1995 Nov 6;3743:419-25..
D. Pohler, E. Butt, J. Meissner, S. Muller, M. Lohse, U. Walter, S. M. Lohmann, and T. Jarchau. FEBS Lett 374(3):419-25 (November 1995)Pohler, D Butt, E Meissner, J Muller, S Lohse, M Walter, U Lohmann, S M Jarchau, T Research Support, Non-U.S. Gov't Netherlands FEBS letters FEBS Lett. 1995 Nov 6;3743:419-25..
2 years and 6 months ago
by pharmawuerz
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& *Gene Affinity Animals Baculoviridae/*genetics Chromatography, Cultured Cyclic Expression Female Fractions/enzymology GMP-Dependent GMP/analogs Humans Intestines/enzymology Isoenzymes/*genetics/isolation Kinases/*genetics/isolation Placenta/enzymology Protein Proteins Rats Recombinant Spodoptera/metabolism Subcellular derivatives/pharmacology purification/metabolism Cell
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