@article{noauthororeditor,
  abstract = {The humoral immune response to SARS-CoV-2 is a benchmark for immunity and detailed analysis is required to understand the manifestation and progression of COVID-19, monitor seroconversion within the general population, and support vaccine development. The majority of currently available commercial serological assays only quantify the SARS-CoV-2 antibody response against individual antigens, limiting our understanding of the immune response. To overcome this, we have developed a multiplex immunoassay (MultiCoV-Ab) including spike and nucleocapsid proteins of SARS-CoV-2 and the endemic human coronaviruses. Compared to three broadly used commercial in vitro diagnostic tests, our MultiCoV-Ab achieves a higher sensitivity and specificity when analyzing a well-characterized sample set of SARS-CoV-2 infected and uninfected individuals. We find a high response against endemic coronaviruses in our sample set, but no consistent cross-reactive IgG response patterns against SARS-CoV-2. Here we show a robust, high-content-enabled, antigen-saving multiplex assay suited to both monitoring vaccination studies and facilitating epidemiologic screenings for humoral immunity towards pandemic and endemic coronaviruses.},
  added-at = {2021-07-19T15:57:19.000+0200},
  author = {Becker, Matthias and Strengert, Monika and Junker, Daniel and Kaiser, Philipp D. and Kerrinnes, Tobias and Traenkle, Bjoern and Dinter, Heiko and Häring, Julia and Ghozzi, Stéphane and Zeck, Anne and Weise, Frank and Peter, Andreas and Hörber, Sebastian and Fink, Simon and Ruoff, Felix and Dulovic, Alex and Bakchoul, Tamam and Baillot, Armin and Lohse, Stefan and Cornberg, Markus and Illig, Thomas and Gottlieb, Jens and Smola, Sigrun and Karch, André and Berger, Klaus and Rammensee, Hans-Georg and Schenke-Layland, Katja and Nelde, Annika and Märklin, Melanie and Heitmann, Jonas S. and Walz, Juliane S. and Templin, Markus and Joos, Thomas O. and Rothbauer, Ulrich and Krause, Gérard and Schneiderhan-Marra, Nicole},
  biburl = {https://www.bibsonomy.org/bibtex/2a98d414741ee6b2346a3486d73d6fd24/sophieschr},
  description = {Exploring beyond clinical routine SARS-CoV-2 serology using MultiCoV-Ab to evaluate endemic coronavirus cross-reactivity | Nature Communications},
  doi = {https://doi.org/10.1038/s41467-021-20973-3},
  interhash = {35ce2080e3ab7c7a979aa031d9e91ed5},
  intrahash = {a98d414741ee6b2346a3486d73d6fd24},
  journal = {Nat Commun},
  keywords = {covid l3s leibnizailab},
  month = feb,
  number = 1152,
  timestamp = {2021-07-19T15:57:19.000+0200},
  title = {Exploring beyond clinical routine SARS-CoV-2 serology using MultiCoV-Ab to evaluate endemic coronavirus cross-reactivity},
  volume = 12,
  year = 2021
}