%0 Journal Article %1 simon2017coadapted %A Simon, Alexis %A Bierne, Nicolas %A Welch, John J. %D 2017 %I Cold Spring Harbor Laboratory %J bioRxiv %K Fishers_geometric_model hybrid_incompatibility speciation %R 10.1101/237925 %T Coadapted genomes and selection on hybrids: Fisher's geometric model explains a variety of empirical patterns %U https://www.biorxiv.org/content/early/2017/12/27/237925 %X Fitness landscape models play an important role in our understanding of speciation, hybridization and admixture. The simplest modeling approaches are best-suited to particular kinds of hybridization: either crosses between closely-related inbred lines, where hybrids are often fitter than their parents, or crosses between effectively isolated species, where breakdown involves discrete incompatibilities of large effect. We study a fitness landscape based on Fisher’s geometric model, and show that it naturally interpolates between these two approaches, while explaining surprising empirical patterns that have been observed in both regimes. The model also yields new predictions, which can be tested with genomic data, and without needing to identify individual loci with anomalous effects. We test these predictions with data from Mytilus mussels, and published data from plants (Zea, Populus and Senecio) and animals (Mus, Teleogryllus and Drosophila), and the predictions are generally supported. Fisher’s geometric model should be particularly useful for studying hybridization in an intermediate regime, where hybrid fitness might be influenced by allelic coadaptation and maladaptation in the parental lines, and where epistatic interactions might involve many loci of moderate effect.

@article{simon2017coadapted, abstract = {Fitness landscape models play an important role in our understanding of speciation, hybridization and admixture. The simplest modeling approaches are best-suited to particular kinds of hybridization: either crosses between closely-related inbred lines, where hybrids are often fitter than their parents, or crosses between effectively isolated species, where breakdown involves discrete incompatibilities of large effect. We study a fitness landscape based on Fisher{\textquoteright}s geometric model, and show that it naturally interpolates between these two approaches, while explaining surprising empirical patterns that have been observed in both regimes. The model also yields new predictions, which can be tested with genomic data, and without needing to identify individual loci with anomalous effects. We test these predictions with data from Mytilus mussels, and published data from plants (Zea, Populus and Senecio) and animals (Mus, Teleogryllus and Drosophila), and the predictions are generally supported. Fisher{\textquoteright}s geometric model should be particularly useful for studying hybridization in an intermediate regime, where hybrid fitness might be influenced by allelic coadaptation and maladaptation in the parental lines, and where epistatic interactions might involve many loci of moderate effect.}, added-at = {2018-01-20T01:07:04.000+0100}, author = {Simon, Alexis and Bierne, Nicolas and Welch, John J.}, biburl = {https://www.bibsonomy.org/bibtex/202c4495b18fbc5be2cf71d9cf2b5e7ac/peter.ralph}, doi = {10.1101/237925}, eprint = {https://www.biorxiv.org/content/early/2017/12/27/237925.full.pdf}, interhash = {05783e3ad14b0bd7502340d748d1011e}, intrahash = {02c4495b18fbc5be2cf71d9cf2b5e7ac}, journal = {bioRxiv}, keywords = {Fishers_geometric_model hybrid_incompatibility speciation}, publisher = {Cold Spring Harbor Laboratory}, timestamp = {2018-01-20T01:07:04.000+0100}, title = {Coadapted genomes and selection on hybrids: {Fisher's} geometric model explains a variety of empirical patterns}, url = {https://www.biorxiv.org/content/early/2017/12/27/237925}, year = 2017 }