%0 Journal Article %1 noauthororeditor %A Hicks, Chindo %A Elnaggar, Jacob %A Wu, Jiande %D 2021 %J Journal of Oncology Research and Therapy (ISSN: 2574-710X) %K Association Gene Genetic Triple breast cancers expression negative variants %N 1 %P 11 %R https://doi.org/10.29011/2574-710X.010103 %T Integrating GWAS with Gene Expression Data to Map the Landscape of Luminal Androgen Receptor and Mesenchymal Subtypes of Triple Negative Breast Cancer %U https://www.gavinpublishers.com/article/view/integrating-gwas-with-gene-expression-data-to-map-the-landscape-of-luminal-androgen-receptor-and-mesenchymal-subtypes-of-triple-negative-breast-cancer %V 6 %X Background: Triple negative breast cancer (TNBC) is the most aggressive and lethal type of breast cancer. It is a heterogeneous disease consisting of many subtypes with distinct molecular and risk profiles. With the exception of cytotoxic chemotherapy, currently there are no effective targeted therapies. There is an urgent need for the discovery of genetic markers that could be used to identify women at high risk of developing subtypes of TNBC at early stages. Here we investigated the potential causal association between genetic susceptibility variants and the two subtypes of TNBC, luminal androgen receptor (LAR) and the mesenchymal (MES) subtypes. Methods: We combined information from genome-wide association studies with gene expression data from the LAR and MES subtypes of TNBC, to identify molecular signatures, gene regulatory networks and signaling pathways enriched for genetic susceptibility variants. Results: The investigation revealed gene signatures, gene regulatory networks and signaling pathways enriched for genetic susceptibility variants associated with the LAR and MES subtypes of TNBC. The networks included genes predicted to be involved in DNA replication, recombination and repair, cell cycle, cell death and cancer. Discovered pathways included the role of BRCA1 in DNA damage response, hereditary breast cancer, aryl hydrocarbon receptor and the molecular mechanisms of cancer signaling pathways. Conclusion: The study revealed that genes containing genetic susceptibility variants are associated with the LAR and MES subtypes of TNBC. Additionally, the study revealed molecular networks and signaling pathways enriched for genetic variants. Further research is recommended to validate the genetic variants in the two subtypes of TNBC.

@article{noauthororeditor, abstract = {Background: Triple negative breast cancer (TNBC) is the most aggressive and lethal type of breast cancer. It is a heterogeneous disease consisting of many subtypes with distinct molecular and risk profiles. With the exception of cytotoxic chemotherapy, currently there are no effective targeted therapies. There is an urgent need for the discovery of genetic markers that could be used to identify women at high risk of developing subtypes of TNBC at early stages. Here we investigated the potential causal association between genetic susceptibility variants and the two subtypes of TNBC, luminal androgen receptor (LAR) and the mesenchymal (MES) subtypes. Methods: We combined information from genome-wide association studies with gene expression data from the LAR and MES subtypes of TNBC, to identify molecular signatures, gene regulatory networks and signaling pathways enriched for genetic susceptibility variants. Results: The investigation revealed gene signatures, gene regulatory networks and signaling pathways enriched for genetic susceptibility variants associated with the LAR and MES subtypes of TNBC. The networks included genes predicted to be involved in DNA replication, recombination and repair, cell cycle, cell death and cancer. Discovered pathways included the role of BRCA1 in DNA damage response, hereditary breast cancer, aryl hydrocarbon receptor and the molecular mechanisms of cancer signaling pathways. Conclusion: The study revealed that genes containing genetic susceptibility variants are associated with the LAR and MES subtypes of TNBC. Additionally, the study revealed molecular networks and signaling pathways enriched for genetic variants. Further research is recommended to validate the genetic variants in the two subtypes of TNBC.}, added-at = {2021-01-21T11:40:23.000+0100}, author = {Hicks, Chindo and Elnaggar, Jacob and Wu, Jiande}, biburl = {https://www.bibsonomy.org/bibtex/263cdda559a551ee987083571d36b8221/alyssacarter}, doi = {https://doi.org/10.29011/2574-710X.010103}, interhash = {06f98badadc46e4332c0a918f6d7c226}, intrahash = {63cdda559a551ee987083571d36b8221}, issn = {ISSN: 2574-710X}, journal = {Journal of Oncology Research and Therapy (ISSN: 2574-710X)}, keywords = {Association Gene Genetic Triple breast cancers expression negative variants}, language = {english}, month = {January}, number = 1, pages = 11, timestamp = {2021-10-09T12:43:33.000+0200}, title = {Integrating GWAS with Gene Expression Data to Map the Landscape of Luminal Androgen Receptor and Mesenchymal Subtypes of Triple Negative Breast Cancer}, url = {https://www.gavinpublishers.com/article/view/integrating-gwas-with-gene-expression-data-to-map-the-landscape-of-luminal-androgen-receptor-and-mesenchymal-subtypes-of-triple-negative-breast-cancer}, volume = 6, year = 2021 }