%0 Journal Article %1 You.2008 %A You, Benoit %A Tranchand, Brigitte %A Girard, Pascal %A Falandry, Claire %A Ribba, Benjamin %A Chabaud, Sylvie %A Souquet, Pierre-Jean %A Court-Fortune, Isabelle %A Trillet-Lenoir, Véronique %A Fournel, Cécile %A Tod, Michel %A Freyer, Gilles %D 2008 %J Lung cancer (Amsterdam, Netherlands) %K & 80 Adult Aged Aged, Antineoplastic Area Carboplatinadministration Carcinomadrug Cell Chemotherapy Chromatography, Clearance Combined Curve Doxorubicinadministration Estimate Etoposideadministration Female Hazards High Humans Ifosfamideadministration Kaplan-Meiers Liquid Lung Male Mesnaadministration Metabolic Middle Models Neoplasmsdrug Pressure Prognosis Proportional Protocolspharmacokineticstherapeutic Rate Small Under and dosage dosagepharmacokinetics over therapymortality use %N 2 %P 261-272 %T Etoposide pharmacokinetics and survival in patients with small cell lung cancer: a multicentre study %V 62 %X PURPOSE: To investigate the prognostic value of systemic exposure to etoposide (Area Under the concentration Curve (AUC(VP16))) on overall survival (OS) in patients with small cell lung cancer (SCLC). PATIENTS AND METHODS: Data from 52 patients with limited stage (n=17) or metastatic (n=35) SCLC were analysed. They received at least two courses of etoposide (120mg/(m(2)day) on 3 days) combined with either doxorubicin-ifosfamide (AVI, n=29) or platinum compounds (carboplatin: n=16; cisplatin: n=7). Population pharmacokinetic-pharmacodynamic (PK-PD) study was performed using NON-linear Mixed Effect Model (NONMEM) and Splus software with univariate and multivariate analyses. RESULTS: Etoposide plasma concentration vs. time was described by a two compartment model. Etoposide clearance (CL) was significantly dependant on serum creatinine (Scr). Ifosfamide (IFO) coadministration increased etoposide clearance by 28% (median CL(VP16): 2.42L/h vs. 1.89L/h, p<0.0005) leading to a reduced systemi

@article{You.2008, abstract = {PURPOSE: To investigate the prognostic value of systemic exposure to etoposide (Area Under the concentration Curve (AUC(VP16))) on overall survival (OS) in patients with small cell lung cancer (SCLC). PATIENTS AND METHODS: Data from 52 patients with limited stage (n=17) or metastatic (n=35) SCLC were analysed. They received at least two courses of etoposide (120mg/(m(2)day) on 3 days) combined with either doxorubicin-ifosfamide (AVI, n=29) or platinum compounds (carboplatin: n=16; cisplatin: n=7). Population pharmacokinetic-pharmacodynamic (PK-PD) study was performed using NON-linear Mixed Effect Model (NONMEM) and Splus software with univariate and multivariate analyses. RESULTS: Etoposide plasma concentration vs. time was described by a two compartment model. Etoposide clearance (CL) was significantly dependant on serum creatinine (Scr). Ifosfamide (IFO) coadministration increased etoposide clearance by 28% (median CL(VP16): 2.42L/h vs. 1.89L/h, p<0.0005) leading to a reduced systemi}, added-at = {2010-02-04T16:31:48.000+0100}, author = {You, Benoit and Tranchand, Brigitte and Girard, Pascal and Falandry, Claire and Ribba, Benjamin and Chabaud, Sylvie and Souquet, Pierre-Jean and Court-Fortune, Isabelle and Trillet-Lenoir, Véronique and Fournel, Cécile and Tod, Michel and Freyer, Gilles}, biburl = {https://www.bibsonomy.org/bibtex/2a1dea6b817e2247c470badacd57554e5/hruehs}, interhash = {0c2b893dca75b908d638397e8df58ccc}, intrahash = {a1dea6b817e2247c470badacd57554e5}, issn = {0169-5002}, journal = {Lung cancer (Amsterdam, Netherlands)}, keywords = {& 80 Adult Aged Aged, Antineoplastic Area Carboplatinadministration Carcinomadrug Cell Chemotherapy Chromatography, Clearance Combined Curve Doxorubicinadministration Estimate Etoposideadministration Female Hazards High Humans Ifosfamideadministration Kaplan-Meiers Liquid Lung Male Mesnaadministration Metabolic Middle Models Neoplasmsdrug Pressure Prognosis Proportional Protocolspharmacokineticstherapeutic Rate Small Under and dosage dosagepharmacokinetics over therapymortality use}, number = 2, pages = {261-272}, timestamp = {2010-02-04T16:31:52.000+0100}, title = {Etoposide pharmacokinetics and survival in patients with small cell lung cancer: a multicentre study}, volume = 62, year = 2008 }