%0 Journal Article %1 bescos2025nitrate %A Bescos, Raul %A Gallardo-Alfaro, Laura %A Ashor, Ammar %A Rizzolo-Brime, Lucia %A Siervo, Mario %A Casas-Agustench, Patricia %C United States %D 2025 %J Free radical biology & medicine %K grapp-caib %P 70--83 %R 10.1016/j.freeradbiomed.2024.11.010 %T Nitrate and nitrite bioavailability in plasma and saliva: Their association with blood pressure - A systematic review and meta-analysis %U https://pubmed.ncbi.nlm.nih.gov/39522567 %V 226 %X In this study, we conducted a systematic review and meta-analysis to determine plasma and salivary nitrate (NO(3)(-)) and nitrite (NO(2)(-)) concentrations under resting and fasting conditions in different type of individuals and their association with blood pressure levels. A total of 77 studies, involving 1918 individuals aged 19-74 years (males = 906; females = 1012), which measured plasma and/or salivary NO(3)(-) and NO(2)(-) using the chemiluminescence technique, were included. Mean plasma NO(3)(-) and NO(2)(-) concentrations were 33.9 μmol/L and 158.3 nmol/L, respectively. Subgroup analyses revealed lower plasma NO(3)(-) and NO(2)(-) concentrations in individuals with cardiometabolic risk (NO(3)(-): 21.2 μmol/L; 95 % CI, 13.4-29.0; NO(2)(-): 122.8 nmol/L; 95 % CI, 75.3-138.9) compared to healthy (NO(3)(-): 33.9 μmol/L; 95 % CI, 29.9-37.9; NO(2)(-): 159.5 nmol/L; 95 % CI, 131.8-187.1; P < 0.01) and trained individuals (NO(3)(-): 43.0 μmol/L; 95 % CI, 13.2-72.9; NO(2)(-): 199.3 nmol/L; 95 % CI, 117.6-281; P < 0.01). Mean salivary NO(3)(-) and NO(2)(-) concentrations were 546.2 μmol/L and 197.8 μmol/L, respectively. Salivary NO(3)(-), but no NO(2)(-), concentrations were higher in individuals with cardiometabolic risk (680.0 μmol/L; 95 % CI, 510.2-849.8; P = 0.001) compared to healthy individuals (535.9 μmol/L; 95 % CI, 384.2-687.6). A significant positive association (coefficient, 15.4 95 % CI, 0.255 to 30.5, P = 0.046) was observed between salivary NO(3)(-) and diastolic blood pressure (DBP). These findings suggest that the health status is positively associated with plasma NO(3)(-) and NO(2)(-) concentrations, but the circulatory levels of these anions are not associated with blood pressure. Only salivary NO(3)(-) showed a significant positive association with DBP.

@article{bescos2025nitrate, abstract = {In this study, we conducted a systematic review and meta-analysis to determine plasma and salivary nitrate (NO(3)(-)) and nitrite (NO(2)(-)) concentrations under resting and fasting conditions in different type of individuals and their association with blood pressure levels. A total of 77 studies, involving 1918 individuals aged 19-74 years (males = 906; females = 1012), which measured plasma and/or salivary NO(3)(-) and NO(2)(-) using the chemiluminescence technique, were included. Mean plasma NO(3)(-) and NO(2)(-) concentrations were 33.9 μmol/L and 158.3 nmol/L, respectively. Subgroup analyses revealed lower plasma NO(3)(-) and NO(2)(-) concentrations in individuals with cardiometabolic risk (NO(3)(-): 21.2 μmol/L; 95 % CI, 13.4-29.0; NO(2)(-): 122.8 nmol/L; 95 % CI, 75.3-138.9) compared to healthy (NO(3)(-): 33.9 μmol/L; 95 % CI, 29.9-37.9; NO(2)(-): 159.5 nmol/L; 95 % CI, 131.8-187.1; P < 0.01) and trained individuals (NO(3)(-): 43.0 μmol/L; 95 % CI, 13.2-72.9; NO(2)(-): 199.3 nmol/L; 95 % CI, 117.6-281; P < 0.01). Mean salivary NO(3)(-) and NO(2)(-) concentrations were 546.2 μmol/L and 197.8 μmol/L, respectively. Salivary NO(3)(-), but no NO(2)(-), concentrations were higher in individuals with cardiometabolic risk (680.0 μmol/L; 95 % CI, 510.2-849.8; P = 0.001) compared to healthy individuals (535.9 μmol/L; 95 % CI, 384.2-687.6). A significant positive association (coefficient, 15.4 [95 % CI, 0.255 to 30.5], P = 0.046) was observed between salivary NO(3)(-) and diastolic blood pressure (DBP). These findings suggest that the health status is positively associated with plasma NO(3)(-) and NO(2)(-) concentrations, but the circulatory levels of these anions are not associated with blood pressure. Only salivary NO(3)(-) showed a significant positive association with DBP.}, added-at = {2024-12-16T06:28:19.000+0100}, address = {United States}, author = {Bescos, Raul and Gallardo-Alfaro, Laura and Ashor, Ammar and Rizzolo-Brime, Lucia and Siervo, Mario and Casas-Agustench, Patricia}, biburl = {https://www.bibsonomy.org/bibtex/20efe6201ebf830817048fed3717f4cca/nachoricci}, comment = {39522567[pmid]}, description = {Nitrate and nitrite bioavailability in plasma and saliva: Their association with blood pressure - A systematic review and meta-analysis - PubMed}, doi = {10.1016/j.freeradbiomed.2024.11.010}, interhash = {d13712930d0b97e5f9c9ef2594206f78}, intrahash = {0efe6201ebf830817048fed3717f4cca}, issn = {18734596}, journal = {Free radical biology & medicine}, keywords = {grapp-caib}, month = jan, pages = {70--83}, timestamp = {2024-12-16T06:28:19.000+0100}, title = {Nitrate and nitrite bioavailability in plasma and saliva: Their association with blood pressure - A systematic review and meta-analysis}, url = {https://pubmed.ncbi.nlm.nih.gov/39522567}, volume = 226, year = 2025 }