%0 Journal Article %1 Ishizuka:2000:Gan-To-Kagaku-Ryoho:10969605 %A Ishizuka, N %D 2000 %J Gan To Kagaku Ryoho %K ClinicalTrials DoseFinding oncology phase1 statistics %N 9 %P 1449-1457 %T Continual reassessment method (CRM) %U https://www.ncbi.nlm.nih.gov/pubmed/10969605 %V 27 %X We discuss the basic concept of the continual reassessment method (CRM) and some modifications. The CRM has been proposed as alternatives of traditional cohort design for phase I trials in cancer. To focus on the dilemma between ethical concern and scientific purpose, we review the requirement for the phase I settings and the issues of the traditional cohort design. Then, CRM is introduced so that the essential feature is in the sequential (continual) selection of a dose level for next patients based on the dose-toxicity relationship and in updating the relationship based on patients' response date using Bayesian calculation. Finally we discuss both advantages and pitfalls in practice.

@article{Ishizuka:2000:Gan-To-Kagaku-Ryoho:10969605, abstract = {We discuss the basic concept of the continual reassessment method (CRM) and some modifications. The CRM has been proposed as alternatives of traditional cohort design for phase I trials in cancer. To focus on the dilemma between ethical concern and scientific purpose, we review the requirement for the phase I settings and the issues of the traditional cohort design. Then, CRM is introduced so that the essential feature is in the sequential (continual) selection of a dose level for next patients based on the dose-toxicity relationship and in updating the relationship based on patients' response date using Bayesian calculation. Finally we discuss both advantages and pitfalls in practice.}, added-at = {2019-10-13T12:27:16.000+0200}, author = {Ishizuka, N}, biburl = {https://www.bibsonomy.org/bibtex/282c81b1c5e5fa6f9f0f8d2f0f03bd2e4/jkd}, description = {[Continual reassessment method (CRM)]. - PubMed - NCBI}, interhash = {1182675a04fe4a1b12a0ce2f84bf7e93}, intrahash = {82c81b1c5e5fa6f9f0f8d2f0f03bd2e4}, journal = {Gan To Kagaku Ryoho}, keywords = {ClinicalTrials DoseFinding oncology phase1 statistics}, month = aug, number = 9, pages = {1449-1457}, pmid = {10969605}, timestamp = {2019-10-13T12:27:37.000+0200}, title = {[Continual reassessment method (CRM)]}, url = {https://www.ncbi.nlm.nih.gov/pubmed/10969605}, volume = 27, year = 2000 }