%0 Journal Article %1 giuliani_universal_2006 %A Giuliani, Marzia M %A Adu-Bobie, Jeannette %A Comanducci, Maurizio %A Aricò, Beatrice %A Savino, Silvana %A Santini, Laura %A Brunelli, Brunella %A Bambini, Stefania %A Biolchi, Alessia %A Capecchi, Barbara %A Cartocci, Elena %A Ciucchi, Laura %A Marcello, Federica Di %A Ferlicca, Francesca %A Galli, Barbara %A Luzzi, Enrico %A Masignani, Vega %A Serruto, Davide %A Veggi, Daniele %A Contorni, Mario %A Morandi, Maurizio %A Bartalesi, Alessandro %A Cinotti, Vanda %A Mannucci, Donatella %A Titta, Francesca %A Ovidi, Elisa %A Welsch, Jo Anne %A Granoff, Dan %A Rappuoli, Rino %A Pizza, Mariagrazia %D 2006 %J Proceedings of the National Academy of Sciences of the United States of America %K Animal, Animals, Antibodies, Antigens, B, Bacterial, Disease Electron, Humans, Meningitis, Meningococcal Meningococcal, Mice, Microscopy, Models, Neisseria Rats Serogroup Transmission, Vaccines, meningitidis, %N 29 %P 10834--9 %R 0603940103 %T A universal vaccine for serogroup B meningococcus %V 103 %X Meningitis and sepsis caused by serogroup B meningococcus are two severe diseases that still cause significant mortality. To date there is no universal vaccine that prevents these diseases. In this work, five antigens discovered by reverse vaccinology were expressed in a form suitable for large-scale manufacturing and formulated with adjuvants suitable for human use. The vaccine adjuvanted by aluminum hydroxide induced bactericidal antibodies in mice against 78\% of a panel of 85 meningococcal strains representative of the global population diversity. The strain coverage could be increased to 90\% and above by the addition of CpG oligonucleotides or by using MF59 as adjuvant. The vaccine has the potential to conquer one of the most devastating diseases of childhood.

@article{giuliani_universal_2006, abstract = {Meningitis and sepsis caused by serogroup B meningococcus are two severe diseases that still cause significant mortality. To date there is no universal vaccine that prevents these diseases. In this work, five antigens discovered by reverse vaccinology were expressed in a form suitable for large-scale manufacturing and formulated with adjuvants suitable for human use. The vaccine adjuvanted by aluminum hydroxide induced bactericidal antibodies in mice against 78\% of a panel of 85 meningococcal strains representative of the global population diversity. The strain coverage could be increased to 90\% and above by the addition of {CpG} oligonucleotides or by using {MF59} as adjuvant. The vaccine has the potential to conquer one of the most devastating diseases of childhood.}, added-at = {2011-03-11T10:05:34.000+0100}, author = {Giuliani, Marzia M and {Adu-Bobie}, Jeannette and Comanducci, Maurizio and Aricò, Beatrice and Savino, Silvana and Santini, Laura and Brunelli, Brunella and Bambini, Stefania and Biolchi, Alessia and Capecchi, Barbara and Cartocci, Elena and Ciucchi, Laura and Marcello, Federica Di and Ferlicca, Francesca and Galli, Barbara and Luzzi, Enrico and Masignani, Vega and Serruto, Davide and Veggi, Daniele and Contorni, Mario and Morandi, Maurizio and Bartalesi, Alessandro and Cinotti, Vanda and Mannucci, Donatella and Titta, Francesca and Ovidi, Elisa and Welsch, Jo Anne and Granoff, Dan and Rappuoli, Rino and Pizza, Mariagrazia}, biburl = {https://www.bibsonomy.org/bibtex/2c1696a7aedf1d1db16ea53eb1057c93c/jelias}, doi = {0603940103}, interhash = {1e6f08a4b147c42b9cd72d0cf35a9560}, intrahash = {c1696a7aedf1d1db16ea53eb1057c93c}, issn = {0027-8424}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, keywords = {Animal, Animals, Antibodies, Antigens, B, Bacterial, Disease Electron, Humans, Meningitis, Meningococcal Meningococcal, Mice, Microscopy, Models, Neisseria Rats Serogroup Transmission, Vaccines, meningitidis,}, month = jul, note = {{PMID:} 16825336}, number = 29, pages = {10834--9}, timestamp = {2011-03-11T10:06:40.000+0100}, title = {A universal vaccine for serogroup B meningococcus}, volume = 103, year = 2006 }