%0 Journal Article %1 adden2006phosphonic %A Adden, Nina %A Gamble, Lara J. %A Castner, David G. %A Hoffmann, Andrea %A Gross, Gerhard %A Menzel, Henning %D 2006 %J Langmuir %K ecm fabrication phd %N 19 %P 8197--8204 %R 10.1021/la060754c %T Phosphonic Acid Monolayers for Binding of Bioactive Molecules to Titanium Surfaces %U http://pubs.acs.org/doi/abs/10.1021/la060754c %V 22 %X Two different phosphonic acid monolayer films for immobilization of bioactive molecules such as the protein BMP-2 on titanium surfaces have been prepared. Monolayers of (11-hydroxyundecyl)phosphonic acid and (12-carboxydodecyl)phosphonic acid molecules were produced by a simple dipping process (the T-BAG method). The terminal functional groups on these monolayers were activated (carbonyldiimidazole for hydroxyl groups and N-hydroxysuccinimide for carboxyl groups) to bind amine-containing molecules. The reactivity of the surfaces was investigated using trifluoroethylamine hydrochloride and BMP-2. Each step of the surface modification procedure was characterized by X-ray photoelectron spectroscopy and time-of-flight secondary ion mass spectrometry.

@article{adden2006phosphonic, abstract = { Two different phosphonic acid monolayer films for immobilization of bioactive molecules such as the protein BMP-2 on titanium surfaces have been prepared. Monolayers of (11-hydroxyundecyl)phosphonic acid and (12-carboxydodecyl)phosphonic acid molecules were produced by a simple dipping process (the T-BAG method). The terminal functional groups on these monolayers were activated (carbonyldiimidazole for hydroxyl groups and N-hydroxysuccinimide for carboxyl groups) to bind amine-containing molecules. The reactivity of the surfaces was investigated using trifluoroethylamine hydrochloride and BMP-2. Each step of the surface modification procedure was characterized by X-ray photoelectron spectroscopy and time-of-flight secondary ion mass spectrometry. }, added-at = {2012-04-05T14:33:18.000+0200}, author = {Adden, Nina and Gamble, Lara J. and Castner, David G. and Hoffmann, Andrea and Gross, Gerhard and Menzel, Henning}, biburl = {https://www.bibsonomy.org/bibtex/2420162755b596addfea1eb1eb8f5551b/bkoch}, description = {Phosphonic Acid Monolayers for Binding of Bioactive Molecules to Titanium Surfaces - Langmuir (ACS Publications)}, doi = {10.1021/la060754c}, eprint = {http://pubs.acs.org/doi/pdf/10.1021/la060754c}, interhash = {11ee4d12af1747ef588f79d97b4274a3}, intrahash = {420162755b596addfea1eb1eb8f5551b}, journal = {Langmuir}, keywords = {ecm fabrication phd}, number = 19, pages = {8197--8204}, timestamp = {2012-04-05T14:33:18.000+0200}, title = {Phosphonic Acid Monolayers for Binding of Bioactive Molecules to Titanium Surfaces}, url = {http://pubs.acs.org/doi/abs/10.1021/la060754c}, volume = 22, year = 2006 }