%0 Journal Article %1 coulson_meningococcal_2007 %A Coulson, Garry B %A von Gottberg, Anne %A du Plessis, Mignon %A Smith, Anthony M %A de Gouveia, Linda %A Klugman, Keith P %D 2007 %J Emerging Infectious Diseases %K Africa Epidemiology, Humans, Infections, Meningococcal Molecular, Neisseria Serotyping, South meningitidis, %N 2 %P 273--281 %T Meningococcal disease in South Africa, 1999-2002 %U http://www.ncbi.nlm.nih.gov/pubmed/17479891 %V 13 %X We describe the epidemiology of invasive meningococcal disease in South Africa from August 1999 through July 2002, as reported to a laboratory-based surveillance system. Neisseria meningitidis isolates were further characterized. In total, 854 cases of laboratory-confirmed disease were reported, with an annual incidence rate of 0.64/100,000 population. Incidence was highest in infants \textless 1 year of age. Serogroup B caused 41\% of cases; serogroup A, 23\%; serogroup Y, 21\%; serogroup C, 8\%; and serogroup W135, 5\%. Serogroup B was the predominant serogroup in Western Cape Province, and disease rates remained stable. Serogroup A was most prevalent in Gauteng Province and increased over the 3 years. On pulsed-field gel electrophoresis analysis, serogroup A strains showed clonality, and serogroup B demonstrated considerable diversity. Selected isolates of serogroup A belonged to sequence type (ST)-1 (subgroup I/II) complex, serogroup B to ST-32/electrophoretic type (ET)-5 complex, and serogroup W135 to ST-11/ET-37 complex.

@article{coulson_meningococcal_2007, abstract = {We describe the epidemiology of invasive meningococcal disease in South Africa from August 1999 through July 2002, as reported to a laboratory-based surveillance system. Neisseria meningitidis isolates were further characterized. In total, 854 cases of laboratory-confirmed disease were reported, with an annual incidence rate of 0.64/100,000 population. Incidence was highest in infants {\textless} 1 year of age. Serogroup B caused 41\% of cases; serogroup A, 23\%; serogroup Y, 21\%; serogroup C, 8\%; and serogroup W135, 5\%. Serogroup B was the predominant serogroup in Western Cape Province, and disease rates remained stable. Serogroup A was most prevalent in Gauteng Province and increased over the 3 years. On pulsed-field gel electrophoresis analysis, serogroup A strains showed clonality, and serogroup B demonstrated considerable diversity. Selected isolates of serogroup A belonged to sequence type {(ST)-1} (subgroup {I/II)} complex, serogroup B to {ST-32/electrophoretic} type {(ET)-5} complex, and serogroup W135 to {ST-11/ET-37} complex.}, added-at = {2011-03-11T10:05:34.000+0100}, author = {Coulson, Garry B and von Gottberg, Anne and du Plessis, Mignon and Smith, Anthony M and de Gouveia, Linda and Klugman, Keith P}, biburl = {https://www.bibsonomy.org/bibtex/2a25d43663ee3f37afcf1a4caaa477ebc/jelias}, interhash = {1375a99782f008673a7c05341dcf4304}, intrahash = {a25d43663ee3f37afcf1a4caaa477ebc}, issn = {1080-6040}, journal = {Emerging Infectious Diseases}, keywords = {Africa Epidemiology, Humans, Infections, Meningococcal Molecular, Neisseria Serotyping, South meningitidis,}, month = feb, note = {{PMID:} 17479891}, number = 2, pages = {273--281}, timestamp = {2011-03-11T10:06:26.000+0100}, title = {Meningococcal disease in South Africa, 1999-2002}, url = {http://www.ncbi.nlm.nih.gov/pubmed/17479891}, volume = 13, year = 2007 }