%0 Journal Article %1 Pajusola.1992 %A Pajusola, K. %A Aprelikova, O. %A Korhonen, J. %A Kaipainen, A. %A Pertovaara, L. %A Alitalo, R. %A Alitalo, K. %D 1992 %J Cancer Res. %K & Acid Amino Base Blood Cell Cells Chemistry Cloning Conformation Data Development Differentiation Distribution Dna Down-Regulation Embryonic Endothelial Epithelial Expression Factor Fetal Gene Growth Homology Human Humans Immunoglobulins Kinase Kinases Leukemia Line Lung Molecular Nucleic Protein Protein-Tyrosine Receptor-3 Receptors Research Sequence Species Specificity Surface Teratoma Tissue Tyrosine Vascular Vessels and blood cells genetics isolation pathology protein purification %N 20 %P 5738-5743 %T FLT4 receptor tyrosine kinase contains seven immunoglobulin-like loops and is expressed in multiple human tissues and cell lines %U PM:1327515 %V 52 %X The fms-like tyrosine kinase 4 (FLT4) complementary DNA was cloned from a human HEL erythroleukemia cell library by polymerase chain reaction-amplification. We previously reported a partial sequence of FLT4 and showed that the FLT4 gene maps to chromosomal region 5q33-qter (O. Aprelikova, K. Pajusola, J. Partanen, E. Armstrong, R. Alitalo, S. Bailey, J. McMahon, J. Wasmuth, K. Huebner, and K. Alitalo, Cancer Res., 52: 746-748, 1992). Here we present the full-length sequence of the predicted FLT4 protein. The extracellular domain of FLT4 consists of 7 immunoglobulin-like loops, including 12 potential glycosylation sites. On the basis of structural similarities FLT4 and the previously known FLT1 and kinase insert domain-containing receptor tyrosine kinase/fetal liver kinase 1 (KDR/FLK1) receptors constitute a subfamily of class III tyrosine kinases. FLT4 was expressed as 5.8- and 4.5-kilobase mRNAs which were found to differ in their 3' sequences and to be differentially expressed in the

@article{Pajusola.1992, abstract = {The fms-like tyrosine kinase 4 (FLT4) complementary DNA was cloned from a human HEL erythroleukemia cell library by polymerase chain reaction-amplification. We previously reported a partial sequence of FLT4 and showed that the FLT4 gene maps to chromosomal region 5q33-qter (O. Aprelikova, K. Pajusola, J. Partanen, E. Armstrong, R. Alitalo, S. Bailey, J. McMahon, J. Wasmuth, K. Huebner, and K. Alitalo, Cancer Res., 52: 746-748, 1992). Here we present the full-length sequence of the predicted FLT4 protein. The extracellular domain of FLT4 consists of 7 immunoglobulin-like loops, including 12 potential glycosylation sites. On the basis of structural similarities FLT4 and the previously known FLT1 and kinase insert domain-containing receptor tyrosine kinase/fetal liver kinase 1 (KDR/FLK1) receptors constitute a subfamily of class III tyrosine kinases. FLT4 was expressed as 5.8- and 4.5-kilobase mRNAs which were found to differ in their 3' sequences and to be differentially expressed in the}, added-at = {2010-02-05T11:28:39.000+0100}, author = {Pajusola, K. and Aprelikova, O. and Korhonen, J. and Kaipainen, A. and Pertovaara, L. and Alitalo, R. and Alitalo, K.}, biburl = {https://www.bibsonomy.org/bibtex/27828c679111652379662d16686c669d3/kanefendt}, interhash = {4e3360a679ba6ffab83ef4ca63b4c208}, intrahash = {7828c679111652379662d16686c669d3}, journal = {Cancer Res.}, keywords = {& Acid Amino Base Blood Cell Cells Chemistry Cloning Conformation Data Development Differentiation Distribution Dna Down-Regulation Embryonic Endothelial Epithelial Expression Factor Fetal Gene Growth Homology Human Humans Immunoglobulins Kinase Kinases Leukemia Line Lung Molecular Nucleic Protein Protein-Tyrosine Receptor-3 Receptors Research Sequence Species Specificity Surface Teratoma Tissue Tyrosine Vascular Vessels and blood cells genetics isolation pathology protein purification}, number = 20, pages = {5738-5743}, timestamp = {2010-02-05T11:28:44.000+0100}, title = {FLT4 receptor tyrosine kinase contains seven immunoglobulin-like loops and is expressed in multiple human tissues and cell lines}, url = {PM:1327515}, volume = 52, year = 1992 }