%0 Journal Article %1 WOS:000381770400024 %A Honorato, Sara B %A da Silva, Cecilia C P %A de Oliveira, Yara S %A Mendonca, Jorge S %A Boechat, Nubia %A Ellena, Javier %A Ayala, Alejandro P %C 111 RIVER ST, HOBOKEN 07030-5774, NJ USA %D 2016 %I WILEY %J JOURNAL OF PHARMACEUTICAL SCIENCES %K Raman analysis; infrared salts/salt selection} solid spectroscopy; state; {thermal %N 8 %P 2437-2443 %R 10.1016/j.xphs.2016.06.003 %T On the Thermal Stability of the Diethylcarbamazine-Fortified Table Salt Used in the Control of Lymphatic Filariasis %V 105 %X Diethylcarbamazine, administered as a water-soluble citrate salt, has been used for more than 50 years as the first-line drug in the treatment of lymphatic filariasis. Mass drug administration programs have been successful in reducing microfilaremia and providing important collateral deworming benefits. One of these initiatives is based on the addition of diethylcarbamazine citrate to table salt. The fortified salt retaining the efficacy of the drug in reducing microfilaremia, but there is little information about its behavior above room temperature. In this study, the thermal stability of diethylcarbamazine, as a free base and a citrate salt, was investigated by differential scanning calorimetry and thermogravimetry under different conditions. Diethylcarbamazine does not release hazardous degradation substances above its melting point. It was also confirmed that this drug is stable at normal cooking temperatures, even when dry heat cooking methods, such as baking or grilling, are considered. However, if the drug is formulated as a salt, as in the case of the citrate, special attention needs to be given to the degradation substances of the counter ion. (C) 2016 American Pharmacists Association (R). Published by Elsevier Inc. All rights reserved.

@article{WOS:000381770400024, abstract = {Diethylcarbamazine, administered as a water-soluble citrate salt, has been used for more than 50 years as the first-line drug in the treatment of lymphatic filariasis. Mass drug administration programs have been successful in reducing microfilaremia and providing important collateral deworming benefits. One of these initiatives is based on the addition of diethylcarbamazine citrate to table salt. The fortified salt retaining the efficacy of the drug in reducing microfilaremia, but there is little information about its behavior above room temperature. In this study, the thermal stability of diethylcarbamazine, as a free base and a citrate salt, was investigated by differential scanning calorimetry and thermogravimetry under different conditions. Diethylcarbamazine does not release hazardous degradation substances above its melting point. It was also confirmed that this drug is stable at normal cooking temperatures, even when dry heat cooking methods, such as baking or grilling, are considered. However, if the drug is formulated as a salt, as in the case of the citrate, special attention needs to be given to the degradation substances of the counter ion. (C) 2016 American Pharmacists Association (R). Published by Elsevier Inc. All rights reserved.}, added-at = {2022-05-23T20:00:14.000+0200}, address = {111 RIVER ST, HOBOKEN 07030-5774, NJ USA}, author = {Honorato, Sara B and da Silva, Cecilia C P and de Oliveira, Yara S and Mendonca, Jorge S and Boechat, Nubia and Ellena, Javier and Ayala, Alejandro P}, biburl = {https://www.bibsonomy.org/bibtex/2fd27464f3383f40d0052a8aa2a6e085f/ppgfis_ufc_br}, doi = {10.1016/j.xphs.2016.06.003}, interhash = {16f911add3dfb86d2c713f99e3aea499}, intrahash = {fd27464f3383f40d0052a8aa2a6e085f}, issn = {0022-3549}, journal = {JOURNAL OF PHARMACEUTICAL SCIENCES}, keywords = {Raman analysis; infrared salts/salt selection} solid spectroscopy; state; {thermal}, number = 8, pages = {2437-2443}, publisher = {WILEY}, pubstate = {published}, timestamp = {2022-05-23T20:00:14.000+0200}, title = {On the Thermal Stability of the Diethylcarbamazine-Fortified Table Salt Used in the Control of Lymphatic Filariasis}, tppubtype = {article}, volume = 105, year = 2016 }