The advent of functional neuroimaging has allowed tremendous advances
in our understanding of brain-language relationships, in addition
to generating substantial empirical data on this subject in the form
of thousands of activation peak coordinates reported in a decade
of language studies. We performed a large-scale meta-analysis of
this literature, aimed at defining the composition of the phonological,
semantic, and sentence processing networks in the frontal, temporal,
and inferior parietal regions of the left cerebral hemisphere. For
each of these language components, activation peaks issued from relevant
component-specific contrasts were submitted to a spatial clustering
algorithm, which gathered activation peaks on the basis of their
relative distance in the MNI space. From a sample of 730 activation
peaks extracted from 129 scientific reports selected among 260, we
isolated 30 activation clusters, defining the functional fields constituting
three distributed networks of frontal and temporal areas and revealing
the functional organization of the left hemisphere for language.
The functional role of each activation cluster is discussed based
on the nature of the tasks in which it was involved. This meta-analysis
sheds light on several contemporary issues, notably on the fine-scale
functional architecture of the inferior frontal gyrus for phonological
and semantic processing, the evidence for an elementary audio-motor
loop involved in both comprehension and production of syllables including
the primary auditory areas and the motor mouth area, evidence of
areas of overlap between phonological and semantic processing, in
particular at the location of the selective human voice area that
was the seat of partial overlap of the three language components,
the evidence of a cortical area in the pars opercularis of the inferior
frontal gyrus dedicated to syntactic processing and in the posterior
part of the superior temporal gyrus a region selectively activated
by sentence and text processing, and the hypothesis that different
working memory perception-actions loops are identifiable for the
different language components. These results argue for large-scale
architecture networks rather than modular organization of language
in the left hemisphere.
%0 Journal Article
%1 Vigneau2006
%A Vigneau, M.
%A Beaucousin, V.
%A Herv�, P. Y.
%A Duffau, H.
%A Crivello, F.
%A Houd�, O.
%A Mazoyer, B.
%A Tzourio-Mazoyer, N.
%D 2006
%J Neuroimage
%K Analysis; Brain Cerebral Cerebral; Cluster Computer-Assisted; Cortex; Dominance, Humans; Image Imaging, Imaging; Language; Magnetic Mapping; Memory, Nerve Net; Perception Phonation; Phonetics; Processing, Reading; Resonance Semantics; Short-Term; Speech Three-Dimensional;
%P 1414--1432
%R 10.1016/j.neuroimage.2005.11.002
%T Meta-analyzing left hemisphere language areas: phonology, semantics,
and sentence processing.
%U http://dx.doi.org/10.1016/j.neuroimage.2005.11.002
%V 30
%X The advent of functional neuroimaging has allowed tremendous advances
in our understanding of brain-language relationships, in addition
to generating substantial empirical data on this subject in the form
of thousands of activation peak coordinates reported in a decade
of language studies. We performed a large-scale meta-analysis of
this literature, aimed at defining the composition of the phonological,
semantic, and sentence processing networks in the frontal, temporal,
and inferior parietal regions of the left cerebral hemisphere. For
each of these language components, activation peaks issued from relevant
component-specific contrasts were submitted to a spatial clustering
algorithm, which gathered activation peaks on the basis of their
relative distance in the MNI space. From a sample of 730 activation
peaks extracted from 129 scientific reports selected among 260, we
isolated 30 activation clusters, defining the functional fields constituting
three distributed networks of frontal and temporal areas and revealing
the functional organization of the left hemisphere for language.
The functional role of each activation cluster is discussed based
on the nature of the tasks in which it was involved. This meta-analysis
sheds light on several contemporary issues, notably on the fine-scale
functional architecture of the inferior frontal gyrus for phonological
and semantic processing, the evidence for an elementary audio-motor
loop involved in both comprehension and production of syllables including
the primary auditory areas and the motor mouth area, evidence of
areas of overlap between phonological and semantic processing, in
particular at the location of the selective human voice area that
was the seat of partial overlap of the three language components,
the evidence of a cortical area in the pars opercularis of the inferior
frontal gyrus dedicated to syntactic processing and in the posterior
part of the superior temporal gyrus a region selectively activated
by sentence and text processing, and the hypothesis that different
working memory perception-actions loops are identifiable for the
different language components. These results argue for large-scale
architecture networks rather than modular organization of language
in the left hemisphere.
@article{Vigneau2006,
abstract = {The advent of functional neuroimaging has allowed tremendous advances
in our understanding of brain-language relationships, in addition
to generating substantial empirical data on this subject in the form
of thousands of activation peak coordinates reported in a decade
of language studies. We performed a large-scale meta-analysis of
this literature, aimed at defining the composition of the phonological,
semantic, and sentence processing networks in the frontal, temporal,
and inferior parietal regions of the left cerebral hemisphere. For
each of these language components, activation peaks issued from relevant
component-specific contrasts were submitted to a spatial clustering
algorithm, which gathered activation peaks on the basis of their
relative distance in the MNI space. From a sample of 730 activation
peaks extracted from 129 scientific reports selected among 260, we
isolated 30 activation clusters, defining the functional fields constituting
three distributed networks of frontal and temporal areas and revealing
the functional organization of the left hemisphere for language.
The functional role of each activation cluster is discussed based
on the nature of the tasks in which it was involved. This meta-analysis
sheds light on several contemporary issues, notably on the fine-scale
functional architecture of the inferior frontal gyrus for phonological
and semantic processing, the evidence for an elementary audio-motor
loop involved in both comprehension and production of syllables including
the primary auditory areas and the motor mouth area, evidence of
areas of overlap between phonological and semantic processing, in
particular at the location of the selective human voice area that
was the seat of partial overlap of the three language components,
the evidence of a cortical area in the pars opercularis of the inferior
frontal gyrus dedicated to syntactic processing and in the posterior
part of the superior temporal gyrus a region selectively activated
by sentence and text processing, and the hypothesis that different
working memory perception-actions loops are identifiable for the
different language components. These results argue for large-scale
architecture networks rather than modular organization of language
in the left hemisphere.},
added-at = {2007-12-16T20:00:22.000+0100},
author = {Vigneau, M. and Beaucousin, V. and Herv�, P. Y. and Duffau, H. and Crivello, F. and Houd�, O. and Mazoyer, B. and Tzourio-Mazoyer, N.},
biburl = {https://www.bibsonomy.org/bibtex/299a39533d95634a72ba354e18a9ceba4/perceptron},
doi = {10.1016/j.neuroimage.2005.11.002},
interhash = {792a6ea4ce92507b286693e84bd15fe9},
intrahash = {99a39533d95634a72ba354e18a9ceba4},
journal = {Neuroimage},
keywords = {Analysis; Brain Cerebral Cerebral; Cluster Computer-Assisted; Cortex; Dominance, Humans; Image Imaging, Imaging; Language; Magnetic Mapping; Memory, Nerve Net; Perception Phonation; Phonetics; Processing, Reading; Resonance Semantics; Short-Term; Speech Three-Dimensional;},
pages = {1414--1432},
pii = {S1053-8119(05)02451-1},
pmid = {16413796},
timestamp = {2007-12-16T20:00:27.000+0100},
title = {Meta-analyzing left hemisphere language areas: phonology, semantics,
and sentence processing.},
url = {http://dx.doi.org/10.1016/j.neuroimage.2005.11.002},
volume = 30,
year = 2006
}