%0 Generic %1 morenoestrada2013reconstructing %A Moreno-Estrada, Andres %A Gravel, Simon %A Zakharia, Fouad %A McCauley, Jacob L. %A Byrnes, Jake K. %A Gignoux, Christopher R. %A Ortiz-Tello, Patricia A. %A Martinez, Ricardo J. %A Hedges, Dale J. %A Morris, Richard W. %A Eng, Celeste %A Sandoval, Karla %A Acevedo-Acevedo, Suehelay %A Martinez-Cruzado, Juan Carlos %A Norman, Paul J. %A Layrisse, Zulay %A Parham, Peter %A Burchard, Esteban Gonzalez %A Cuccaro, Michael L. %A Martin, Eden R. %A Bustamante, Carlos D. %D 2013 %K IBD PCA american_history demographic_inference human_genome population_genomics %T Reconstructing the Population Genetic History of the Caribbean %U http://arxiv.org/abs/1306.0558 %X The Caribbean basin is home to some of the most complex interactions in recent history among previously diverged human populations. Here, by making use of genome-wide SNP array data, we characterize ancestral components of Caribbean populations on a sub-continental level and unveil fine-scale patterns of population structure distinguishing insular from mainland Caribbean populations as well as from other Hispanic/Latino groups. We provide genetic evidence for an inland South American origin of the Native American component in island populations and for extensive pre-Columbian gene flow across the Caribbean basin. The Caribbean-derived European component shows significant differentiation from parental Iberian populations, presumably as a result of founder effects during the colonization of the New World. Based on demographic models, we reconstruct the complex population history of the Caribbean since the onset of continental admixture. We find that insular populations are best modeled as mixtures absorbing two pulses of African migrants, coinciding with early and maximum activity stages of the transatlantic slave trade. These two pulses appear to have originated in different regions within West Africa, imprinting two distinguishable signatures in present day Afro-Caribbean genomes and shedding light on the genetic impact of the dynamics occurring during the slave trade in the Caribbean.

@misc{morenoestrada2013reconstructing, abstract = {The Caribbean basin is home to some of the most complex interactions in recent history among previously diverged human populations. Here, by making use of genome-wide SNP array data, we characterize ancestral components of Caribbean populations on a sub-continental level and unveil fine-scale patterns of population structure distinguishing insular from mainland Caribbean populations as well as from other Hispanic/Latino groups. We provide genetic evidence for an inland South American origin of the Native American component in island populations and for extensive pre-Columbian gene flow across the Caribbean basin. The Caribbean-derived European component shows significant differentiation from parental Iberian populations, presumably as a result of founder effects during the colonization of the New World. Based on demographic models, we reconstruct the complex population history of the Caribbean since the onset of continental admixture. We find that insular populations are best modeled as mixtures absorbing two pulses of African migrants, coinciding with early and maximum activity stages of the transatlantic slave trade. These two pulses appear to have originated in different regions within West Africa, imprinting two distinguishable signatures in present day Afro-Caribbean genomes and shedding light on the genetic impact of the dynamics occurring during the slave trade in the Caribbean.}, added-at = {2013-06-21T16:52:17.000+0200}, author = {Moreno-Estrada, Andres and Gravel, Simon and Zakharia, Fouad and McCauley, Jacob L. and Byrnes, Jake K. and Gignoux, Christopher R. and Ortiz-Tello, Patricia A. and Martinez, Ricardo J. and Hedges, Dale J. and Morris, Richard W. and Eng, Celeste and Sandoval, Karla and Acevedo-Acevedo, Suehelay and Martinez-Cruzado, Juan Carlos and Norman, Paul J. and Layrisse, Zulay and Parham, Peter and Burchard, Esteban Gonzalez and Cuccaro, Michael L. and Martin, Eden R. and Bustamante, Carlos D.}, biburl = {https://www.bibsonomy.org/bibtex/2e97405443f0370069d42a0463982d7d0/peter.ralph}, interhash = {17ffea9e075263f18d4473359fe35dab}, intrahash = {e97405443f0370069d42a0463982d7d0}, keywords = {IBD PCA american_history demographic_inference human_genome population_genomics}, note = {cite arxiv:1306.0558}, timestamp = {2015-01-20T22:35:53.000+0100}, title = {Reconstructing the Population Genetic History of the {Caribbean}}, url = {http://arxiv.org/abs/1306.0558}, year = 2013 }