Abstract
It is reported that Alzheimer disease is linked with hypertension, diabetes type 2 and high cholesterolemia.
The underlying genetic cause relating these diseases are not well studied clinically. But it has been widely
accepted that beta secretase (BACE1) is the main culprit of causing Alzheimer disease. This enzyme comes
under peptidase A1 family. In the present work, ligand based and structure based drug designing have been
reported. QSAR studies were done using 21 gallic acid derivatives dataset to develop good predictive
model in order to predict biological activity and certain descriptors was reported to further enhance the
analgesic activity of gallic acid derivatives. Molecular docking studies were performed in order to find
structure based drug design. Two natural gallic acid derivative have been repoted as a potent inhibitor to
beta secretase enzyme.
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