An outbreak of meningococcal disease among children on a school bus offered the opportunity to study a proposed association between this infection and preceding influenza infection. Five students who rode the bus became ill with invasive group C meningococcus. Transmission was limited to the bus; there was no evidence for school transmission. All five students reported influenza-like symptoms within several weeks before the development of meningococcal disease. School absenteeism, principally due to upper respiratory tract illness, was higher during the 3 weeks before the outbreak of meningococcal disease than during any period in the preceding 3 1/2 years, suggesting an unusually severe outbreak of respiratory illness. A case-control study comparing students with and without influenza symptoms revealed that the outbreak of respiratory disease was due to B/Ann Arbor/1/86 influenza (geometric mean titers, 86 for 80 patients and 33 for 47 controls P = .0007). These data add to the evidence suggesting that influenza respiratory infection predisposes to meningococcal disease.
%0 Journal Article
%1 harrison_cluster_1991
%A Harrison, L H
%A Armstrong, C W
%A Jenkins, S R
%A Harmon, M W
%A Ajello, G W
%A Miller, G B
%A Broome, C V
%D 1991
%J Archives of Internal Medicine
%K Absenteeism, Adolescent, Child, Disease Factors, Human, Humans, Incidence, Infections, Influenza, Meningococcal Outbreaks, Risk Studies, Transportation, Virginia {Case-Control}
%N 5
%P 1005--1009
%T A cluster of meningococcal disease on a school bus following epidemic influenza
%U http://www.ncbi.nlm.nih.gov/pubmed/2025124
%V 151
%X An outbreak of meningococcal disease among children on a school bus offered the opportunity to study a proposed association between this infection and preceding influenza infection. Five students who rode the bus became ill with invasive group C meningococcus. Transmission was limited to the bus; there was no evidence for school transmission. All five students reported influenza-like symptoms within several weeks before the development of meningococcal disease. School absenteeism, principally due to upper respiratory tract illness, was higher during the 3 weeks before the outbreak of meningococcal disease than during any period in the preceding 3 1/2 years, suggesting an unusually severe outbreak of respiratory illness. A case-control study comparing students with and without influenza symptoms revealed that the outbreak of respiratory disease was due to B/Ann Arbor/1/86 influenza (geometric mean titers, 86 for 80 patients and 33 for 47 controls P = .0007). These data add to the evidence suggesting that influenza respiratory infection predisposes to meningococcal disease.
@article{harrison_cluster_1991,
abstract = {An outbreak of meningococcal disease among children on a school bus offered the opportunity to study a proposed association between this infection and preceding influenza infection. Five students who rode the bus became ill with invasive group C meningococcus. Transmission was limited to the bus; there was no evidence for school transmission. All five students reported influenza-like symptoms within several weeks before the development of meningococcal disease. School absenteeism, principally due to upper respiratory tract illness, was higher during the 3 weeks before the outbreak of meningococcal disease than during any period in the preceding 3 1/2 years, suggesting an unusually severe outbreak of respiratory illness. A case-control study comparing students with and without influenza symptoms revealed that the outbreak of respiratory disease was due to {B/Ann} Arbor/1/86 influenza (geometric mean titers, 86 for 80 patients and 33 for 47 controls {[P} = .0007]). These data add to the evidence suggesting that influenza respiratory infection predisposes to meningococcal disease.},
added-at = {2011-03-11T10:05:34.000+0100},
author = {Harrison, L H and Armstrong, C W and Jenkins, S R and Harmon, M W and Ajello, G W and Miller, G B and Broome, C V},
biburl = {https://www.bibsonomy.org/bibtex/2054c6fcfd4793b0ae05d6841cacf558e/jelias},
interhash = {8dde7e176920c0a8bd2f902c0635d09c},
intrahash = {054c6fcfd4793b0ae05d6841cacf558e},
issn = {0003-9926},
journal = {Archives of Internal Medicine},
keywords = {Absenteeism, Adolescent, Child, Disease Factors, Human, Humans, Incidence, Infections, Influenza, Meningococcal Outbreaks, Risk Studies, Transportation, Virginia {Case-Control}},
month = may,
note = {{PMID:} 2025124},
number = 5,
pages = {1005--1009},
timestamp = {2011-03-11T10:06:45.000+0100},
title = {A cluster of meningococcal disease on a school bus following epidemic influenza},
url = {http://www.ncbi.nlm.nih.gov/pubmed/2025124},
volume = 151,
year = 1991
}