Abstract
Myocardial ischemia is one of the main causes of sudden cardiac death,
with 80\% of victims suffering from coronary heart disease. In acute
myocardial ischemia, the obstruction of coronary flow leads to the
interruption of oxygen flow, glucose, and washout in the affected
tissue. Cellular metabolism is impaired and severe electrophysiological
changes in ionic currents and concentrations ensue, which favor the
development of lethal cardiac arrhythmias such as ventricular fibrillation.
Due to the burden imposed by ischemia in our societies, a large body
of research has attempted to unravel the mechanisms of initiation,
sustenance, and termination of cardiac arrhythmias in acute ischemia,
but the rapidity and complexity of ischemia-induced changes as well
as the limitations in current experimental techniques have hampered
evaluation of ischemia-induced alterations in cardiac electrical
activity and understanding of the underlying mechanisms. Over the
last decade, computer simulations have demonstrated the ability to
provide insight, with high spatiotemporal resolution, into ischemic
abnormalities in cardiac electrophysiological behavior from the ionic
channel to the whole organ. This article aims to review and summarize
the results of these studies and to emphasize the role of computer
simulations in improving the understanding of ischemia-related arrhythmias
and how to efficiently terminate them.
Description
The whole bibliography file I use.