%0 Journal Article %1 Gevorgyan2008Detection %A Gevorgyan, Albert %A Poolman, Mark G. %A Fell, David A. %D 2008 %I Oxford University Press %J Bioinformatics %K metabolic-networks model-validation reconstruction stoichiometric-analysis %N 19 %P 2245--2251 %R 10.1093/bioinformatics/btn425 %T Detection of stoichiometric inconsistencies in biomolecular models %U http://dx.doi.org/10.1093/bioinformatics/btn425 %V 24 %X Motivation: Metabolic modelling provides a mathematically rigorous basis for system-level analysis of biochemical networks. However, the growing sizes of metabolic models can lead to serious problems in their construction and validation. In this work, we describe a relatively poorly investigated type of modelling error, called stoichiometric inconsistencies. These errors are caused by incorrect definitions of reaction stoichiometries and result in conflicts between two fundamental physical constraints to be satisfied by any valid metabolic model: positivity of molecular masses of all metabolites and mass conservation in all interconversions.

@article{Gevorgyan2008Detection, abstract = {Motivation: Metabolic modelling provides a mathematically rigorous basis for system-level analysis of biochemical networks. However, the growing sizes of metabolic models can lead to serious problems in their construction and validation. In this work, we describe a relatively poorly investigated type of modelling error, called stoichiometric inconsistencies. These errors are caused by incorrect definitions of reaction stoichiometries and result in conflicts between two fundamental physical constraints to be satisfied by any valid metabolic model: positivity of molecular masses of all metabolites and mass conservation in all interconversions.}, added-at = {2018-12-02T16:09:07.000+0100}, author = {Gevorgyan, Albert and Poolman, Mark G. and Fell, David A.}, biburl = {https://www.bibsonomy.org/bibtex/2082b39adff7f1a95c19befcd74cd3dc1/karthikraman}, citeulike-article-id = {4622364}, citeulike-linkout-0 = {http://dx.doi.org/10.1093/bioinformatics/btn425}, citeulike-linkout-1 = {http://bioinformatics.oxfordjournals.org/content/24/19/2245.abstract}, citeulike-linkout-2 = {http://bioinformatics.oxfordjournals.org/content/24/19/2245.full.pdf}, citeulike-linkout-3 = {http://view.ncbi.nlm.nih.gov/pubmed/18697772}, citeulike-linkout-4 = {http://www.hubmed.org/display.cgi?uids=18697772}, day = 01, doi = {10.1093/bioinformatics/btn425}, interhash = {57e8547fdbd5362375ac3cf3b23bba32}, intrahash = {082b39adff7f1a95c19befcd74cd3dc1}, issn = {1460-2059}, journal = {Bioinformatics}, keywords = {metabolic-networks model-validation reconstruction stoichiometric-analysis}, month = oct, number = 19, pages = {2245--2251}, pmid = {18697772}, posted-at = {2011-03-17 12:14:15}, priority = {2}, publisher = {Oxford University Press}, timestamp = {2018-12-02T16:09:07.000+0100}, title = {Detection of stoichiometric inconsistencies in biomolecular models}, url = {http://dx.doi.org/10.1093/bioinformatics/btn425}, volume = 24, year = 2008 }