Beyond the already known aetiopathogenic factors linked to periventricular leukomalacia, a major pathological substrate in cerebral palsy, immune-inflammatory mechanisms have recently been implicated. Thus proinflammatory cytokines have been shown to be involved very early in the course of this disorder. Additionally, markers of T-lymphocyte activation were upregulated. These findings provide new insight into mechanisms underlying neural cell death in this condition and might open new horizons for preventive and therapeutic strategies.
%0 Journal Article
%1 Kadhim2002
%A Kadhim, Hazim
%A S?bire, Guillaume
%D 2002
%J Eur J Paediatr Neurol
%K Brain; Cerebral Palsy; Cytokines; Humans; Infant, Newborn; Leukomalacia, Periventricular; Neurons; Risk Factors; T-Lymphocytes; Tumor Necrosis Factor-alpha
%N 3
%P 139--142
%T Immune mechanisms in the pathogenesis of cerebral palsy: implication of proinflammatory cytokines and T lymphocytes.
%V 6
%X Beyond the already known aetiopathogenic factors linked to periventricular leukomalacia, a major pathological substrate in cerebral palsy, immune-inflammatory mechanisms have recently been implicated. Thus proinflammatory cytokines have been shown to be involved very early in the course of this disorder. Additionally, markers of T-lymphocyte activation were upregulated. These findings provide new insight into mechanisms underlying neural cell death in this condition and might open new horizons for preventive and therapeutic strategies.
@article{Kadhim2002,
abstract = {Beyond the already known aetiopathogenic factors linked to periventricular leukomalacia, a major pathological substrate in cerebral palsy, immune-inflammatory mechanisms have recently been implicated. Thus proinflammatory cytokines have been shown to be involved very early in the course of this disorder. Additionally, markers of T-lymphocyte activation were upregulated. These findings provide new insight into mechanisms underlying neural cell death in this condition and might open new horizons for preventive and therapeutic strategies.},
added-at = {2014-07-19T20:31:24.000+0200},
author = {Kadhim, Hazim and S?bire, Guillaume},
biburl = {https://www.bibsonomy.org/bibtex/20e8dab0f6b087d6bd5f03b87be52a424/ar0berts},
groups = {public},
interhash = {2cbb19eb1a57d57c416c4535361bd027},
intrahash = {0e8dab0f6b087d6bd5f03b87be52a424},
journal = {Eur J Paediatr Neurol},
keywords = {Brain; Cerebral Palsy; Cytokines; Humans; Infant, Newborn; Leukomalacia, Periventricular; Neurons; Risk Factors; T-Lymphocytes; Tumor Necrosis Factor-alpha},
number = 3,
pages = {139--142},
pii = {S1090379802905817},
pmid = {12363100},
timestamp = {2014-07-19T20:31:24.000+0200},
title = {Immune mechanisms in the pathogenesis of cerebral palsy: implication of proinflammatory cytokines and T lymphocytes.},
username = {ar0berts},
volume = 6,
year = 2002
}