@article{Song2016,
  abstract = {Summary Direct induction of induced hepatocytes (iHeps) from fibroblasts holds potential as a strategy for regenerative medicine but until now has only been shown in culture settings. Here, we describe in vivo iHep formation using transcription factor induction and genetic fate tracing in mouse models of chronic liver disease. We show that ectopic expression of the transcription factors FOXA3, GATA4, HNF1A, and \{HNF4A\} from a polycistronic lentiviral vector converts mouse myofibroblasts into cells with a hepatocyte phenotype. In vivo expression of the same set of transcription factors from a p75 neurotrophin receptor peptide (p75NTRp)-tagged adenovirus enabled the generation of hepatocyte-like cells from myofibroblasts in fibrotic mouse livers and reduced liver fibrosis. We have therefore been able to convert pro-fibrogenic myofibroblasts in the liver into hepatocyte-like cells with positive functional benefits. This direct in vivo reprogramming approach may open new avenues for the treatment of chronic liver disease. },
  added-at = {2016-03-14T13:04:14.000+0100},
  author = {Song, G and Pacher, M and Balakrishnan, A and Yuan, Q and Tsay, H C and Yang, D and Reetz, J and Brandes, S and Dai, Z and Pützer, B M and Araúzo-Bravo, M J and Steinemann, D and Luedde, T and Schwabe, R F and Manns, M P and Schöler, H R and Schambach, A and Cantz, T and Ott, M and Sharma, A D},
  biburl = {https://www.bibsonomy.org/bibtex/212fb3a9e59ea042b2b01a0519ce469ce/ott},
  editor = {Cell, Cell Stem},
  interhash = {bb2b79fac6e1d1470d5d45679374d622},
  intrahash = {12fb3a9e59ea042b2b01a0519ce469ce},
  journal = {Cell Stem Cell },
  keywords = {ott},
  number = 6,
  pages = {797-808},
  pubmedurl = {http://www.ncbi.nlm.nih.gov/pubmed/26923201},
  timestamp = {2016-06-07T12:18:51.000+0200},
  title = {Direct Reprogramming of Hepatic Myofibroblasts into Hepatocytes In Vivo Attenuates Liver Fibrosis },
  volume = 18,
  year = 2016
}