%0 Journal Article %1 Clark2001 %A Clark, Jerry D. %A Shah, Ajit S. %A Peterson, James C. %A Grogan, F. Michael %A Camden, Stephanie K. %D 2001 %J Thermochimica Acta %K Beta Ethyl Hazards Process Reaction analysis calorimetry; development; diazoacetate; ester; keto %P 75--84 %R http://dx.doi.org/10.1016/S0040-6031(00)00684-5 %T Application of reaction calorimetry toward understanding the large scale chemistry of ethyl diazoacetate %U http://www.sciencedirect.com/science/article/B6THV-42HFRYY-C/2/247d3973eebb592547398e29355ff068 %V 367-368 %X Ethyl diazoacetate is an important organic chemistry synthon, but its use as an industrial intermediate is limited due in part to the safety concerns associated with its instability and high reactivity. Reported are the reaction calorimetry results obtained from a new ethyl diazoacetate preparative method, the results from its use in a novel, exothermic reaction and the application of this data toward process development, a successful pilot plant campaign and full-scale reactor design. The results indicate that, given the proper engineering design, in situ preparation and use of ethyl diazoacetate solutions can be used at production scale without significant risk.

@article{Clark2001, abstract = {Ethyl diazoacetate is an important organic chemistry synthon, but its use as an industrial intermediate is limited due in part to the safety concerns associated with its instability and high reactivity. Reported are the reaction calorimetry results obtained from a new ethyl diazoacetate preparative method, the results from its use in a novel, exothermic reaction and the application of this data toward process development, a successful pilot plant campaign and full-scale reactor design. The results indicate that, given the proper engineering design, in situ preparation and use of ethyl diazoacetate solutions can be used at production scale without significant risk.}, added-at = {2010-01-05T23:12:10.000+0100}, author = {Clark, Jerry D. and Shah, Ajit S. and Peterson, James C. and Grogan, F. Michael and Camden, Stephanie K.}, biburl = {https://www.bibsonomy.org/bibtex/2d9876b2903506e5ada356090ada5b006/sjp}, day = 8, doi = {http://dx.doi.org/10.1016/S0040-6031(00)00684-5}, interhash = {216320f428f6184b0882b8da920cf798}, intrahash = {d9876b2903506e5ada356090ada5b006}, journal = {Thermochimica Acta}, keywords = {Beta Ethyl Hazards Process Reaction analysis calorimetry; development; diazoacetate; ester; keto}, month = {March}, pages = {75--84}, timestamp = {2010-01-19T17:39:44.000+0100}, title = {{A}pplication of reaction calorimetry toward understanding the large scale chemistry of ethyl diazoacetate}, url = {http://www.sciencedirect.com/science/article/B6THV-42HFRYY-C/2/247d3973eebb592547398e29355ff068}, volume = {367-368}, year = 2001 }