In the sub-Saharan African meningitis belt there is a region of hyperendemic and epidemic meningitis stretching from Senegal to Ethiopia. The public health approaches to meningitis epidemics, including those related to vaccine use, have assumed that Neisseria meningitidis serogroup A will cause the most disease. During 2001 and 2002, the first large-scale epidemics of serogroup W135 meningitis in sub-Saharan Africa were reported from Burkina Faso. The occurrence of N. meningitidis W135 epidemics has led to a host of new issues, including the need for improved laboratory diagnostics for identifying serogroups during epidemics, an affordable supply of serogroup W135-containing polysaccharide vaccine for epidemic control where needed, and re-evaluating the long-term strategy of developing a monovalent A conjugate vaccine for the region. This review summarizes the existing data on N. meningitidis W135 epidemiology, immunology and vaccines as they relate to meningitis in sub-Saharan Africa.
%0 Journal Article
%1 mueller_meningococcal_2006
%A Mueller, Judith E
%A Borrow, Raymond
%A Gessner, Bradford D
%D 2006
%J Expert Review of Vaccines
%K Adolescent, Adult, Africa Carrier Child, Clinical Communicable Disease Diseases, Emerging, Humans, Infant, Meningitis, Meningococcal Meningococcal, Neisseria Outbreaks, Preschool, Sahara, Seroepidemiologic Serogroup Serotyping, South State, Studies, Topic, Trials Vaccination Vaccines, W-135, as meningitidis, of the
%N 3
%P 319--36
%R 10.1586/14760584.5.3.319
%T Meningococcal serogroup W135 in the African meningitis belt: epidemiology, immunity and vaccines
%U http://www.ncbi.nlm.nih.gov/pubmed/16827617
%V 5
%X In the sub-Saharan African meningitis belt there is a region of hyperendemic and epidemic meningitis stretching from Senegal to Ethiopia. The public health approaches to meningitis epidemics, including those related to vaccine use, have assumed that Neisseria meningitidis serogroup A will cause the most disease. During 2001 and 2002, the first large-scale epidemics of serogroup W135 meningitis in sub-Saharan Africa were reported from Burkina Faso. The occurrence of N. meningitidis W135 epidemics has led to a host of new issues, including the need for improved laboratory diagnostics for identifying serogroups during epidemics, an affordable supply of serogroup W135-containing polysaccharide vaccine for epidemic control where needed, and re-evaluating the long-term strategy of developing a monovalent A conjugate vaccine for the region. This review summarizes the existing data on N. meningitidis W135 epidemiology, immunology and vaccines as they relate to meningitis in sub-Saharan Africa.
@article{mueller_meningococcal_2006,
abstract = {In the {sub-Saharan} African meningitis belt there is a region of hyperendemic and epidemic meningitis stretching from Senegal to Ethiopia. The public health approaches to meningitis epidemics, including those related to vaccine use, have assumed that Neisseria meningitidis serogroup A will cause the most disease. During 2001 and 2002, the first large-scale epidemics of serogroup W135 meningitis in {sub-Saharan} Africa were reported from Burkina Faso. The occurrence of N. meningitidis W135 epidemics has led to a host of new issues, including the need for improved laboratory diagnostics for identifying serogroups during epidemics, an affordable supply of serogroup W135-containing polysaccharide vaccine for epidemic control where needed, and re-evaluating the long-term strategy of developing a monovalent A conjugate vaccine for the region. This review summarizes the existing data on N. meningitidis W135 epidemiology, immunology and vaccines as they relate to meningitis in {sub-Saharan} Africa.},
added-at = {2011-03-11T10:05:34.000+0100},
author = {Mueller, Judith E and Borrow, Raymond and Gessner, Bradford D},
biburl = {https://www.bibsonomy.org/bibtex/2249c95bd8e05adcac710e047be1a8ea5/jelias},
doi = {10.1586/14760584.5.3.319},
interhash = {778a3477a72886190cc6ff8f71438f65},
intrahash = {249c95bd8e05adcac710e047be1a8ea5},
issn = {1744-8395},
journal = {Expert Review of Vaccines},
keywords = {Adolescent, Adult, Africa Carrier Child, Clinical Communicable Disease Diseases, Emerging, Humans, Infant, Meningitis, Meningococcal Meningococcal, Neisseria Outbreaks, Preschool, Sahara, Seroepidemiologic Serogroup Serotyping, South State, Studies, Topic, Trials Vaccination Vaccines, W-135, as meningitidis, of the},
month = jun,
note = {{PMID:} 16827617},
number = 3,
pages = {319--36},
shorttitle = {Meningococcal serogroup W135 in the African meningitis belt},
timestamp = {2011-03-11T10:06:39.000+0100},
title = {Meningococcal serogroup W135 in the African meningitis belt: epidemiology, immunity and vaccines},
url = {http://www.ncbi.nlm.nih.gov/pubmed/16827617},
volume = 5,
year = 2006
}