Signaling by internalized G-protein-coupled receptors
D. Calebiro, V. Nikolaev, L. Persani, and M. Lohse. Trends Pharmacol Sci, 31 (5):
221-8(May 2010)Calebiro, Davide Nikolaev, Viacheslav O Persani, Luca Lohse, Martin
J Research Support, Non-U.S. Gov't Review England Trends in pharmacological
sciences Trends Pharmacol Sci. 2010 May;31(5):221-8. Epub 2010 Mar
18..
Abstract
G-protein-coupled receptors (GPCRs) are cell surface receptors and
are generally assumed to signal to second messengers such as cyclic
AMP (cAMP) exclusively from the plasma membrane. However, recent
studies indicate that GPCRs can continue signaling to cAMP after
internalization together with their agonists. Signaling from inside
the cell is persistent and appears to trigger specific downstream
effects. Here, we will review these recent data, which form the basis
for a novel concept of intracellular GPCR signaling and suggest new
and intriguing scenarios for the functions of GPCRs in the endocytic
compartment. We propose that current models of GPCR signaling should
be revised to accommodate the ability of receptors to change their
signaling properties depending on their subcellular localization.
Calebiro, Davide Nikolaev, Viacheslav O Persani, Luca Lohse, Martin
J Research Support, Non-U.S. Gov't Review England Trends in pharmacological
sciences Trends Pharmacol Sci. 2010 May;31(5):221-8. Epub 2010 Mar
18.
%0 Journal Article
%1 Calebiro2010a
%A Calebiro, D.
%A Nikolaev, V. O.
%A Persani, L.
%A Lohse, M. J.
%D 2010
%J Trends Pharmacol Sci
%K *Models, *Signal AMP/metabolism Animals Biological Cyclic Endocytosis G-Protein-Coupled/*metabolism Humans Intracellular Protein Space/metabolism Transduction Transport Receptor
%N 5
%P 221-8
%T Signaling by internalized G-protein-coupled receptors
%U http://www.ncbi.nlm.nih.gov/pubmed/20303186
%V 31
%X G-protein-coupled receptors (GPCRs) are cell surface receptors and
are generally assumed to signal to second messengers such as cyclic
AMP (cAMP) exclusively from the plasma membrane. However, recent
studies indicate that GPCRs can continue signaling to cAMP after
internalization together with their agonists. Signaling from inside
the cell is persistent and appears to trigger specific downstream
effects. Here, we will review these recent data, which form the basis
for a novel concept of intracellular GPCR signaling and suggest new
and intriguing scenarios for the functions of GPCRs in the endocytic
compartment. We propose that current models of GPCR signaling should
be revised to accommodate the ability of receptors to change their
signaling properties depending on their subcellular localization.
@article{Calebiro2010a,
abstract = {G-protein-coupled receptors (GPCRs) are cell surface receptors and
are generally assumed to signal to second messengers such as cyclic
AMP (cAMP) exclusively from the plasma membrane. However, recent
studies indicate that GPCRs can continue signaling to cAMP after
internalization together with their agonists. Signaling from inside
the cell is persistent and appears to trigger specific downstream
effects. Here, we will review these recent data, which form the basis
for a novel concept of intracellular GPCR signaling and suggest new
and intriguing scenarios for the functions of GPCRs in the endocytic
compartment. We propose that current models of GPCR signaling should
be revised to accommodate the ability of receptors to change their
signaling properties depending on their subcellular localization.},
added-at = {2010-12-14T18:12:02.000+0100},
author = {Calebiro, D. and Nikolaev, V. O. and Persani, L. and Lohse, M. J.},
biburl = {https://www.bibsonomy.org/bibtex/2292ecea1ae024623033dd63406938c8b/pharmawuerz},
endnotereftype = {Journal Article},
groups = {private},
interhash = {d6fa9d45a818e7dca4a1082e0649fa50},
intrahash = {292ecea1ae024623033dd63406938c8b},
issn = {1873-3735 (Electronic) 0165-6147 (Linking)},
journal = {Trends Pharmacol Sci},
keywords = {*Models, *Signal AMP/metabolism Animals Biological Cyclic Endocytosis G-Protein-Coupled/*metabolism Humans Intracellular Protein Space/metabolism Transduction Transport Receptor},
month = May,
note = {Calebiro, Davide Nikolaev, Viacheslav O Persani, Luca Lohse, Martin
J Research Support, Non-U.S. Gov't Review England Trends in pharmacological
sciences Trends Pharmacol Sci. 2010 May;31(5):221-8. Epub 2010 Mar
18.},
number = 5,
pages = {221-8},
shorttitle = {Signaling by internalized G-protein-coupled receptors},
timestamp = {2010-12-14T18:20:01.000+0100},
title = {Signaling by internalized G-protein-coupled receptors},
url = {http://www.ncbi.nlm.nih.gov/pubmed/20303186},
volume = 31,
year = 2010
}