Online human conjunctival vessel diameter analysis. A clinical-methodical study
E. Nagel, W. Vilser, and I. Lanzl. Clinical hemorheology and microcirculation, 28 (4):
221--227(2003)
Abstract
BACKGROUND: The present study investigates the possible application of a
commercially available on-line measuring device of retinal vessels for
conjunctival vessel assessment. METHODS: Repeated measurements in one randomly
chosen eye were performed in 11 healthy volunteers (mean age 42.9 +/- 10 years).
Measurements of one conjunctival vessel were obtained first without a stimulus
followed by measurements after the application of one drop of a topical
vasoconstrictor. The examinations were performed by Retinal Vessel Analyzer (RVA,
IMEDOS/Germany). This system determines automatically on-line the vessel diameter
along a chosen vessel segment. RESULTS: Measurements in the native state without
eye drop application showed an intraclass correlation coefficient of 0.97 and a
mean variation coefficient of 1.8\%. After application of the topical
vasoconstrictor a short acting vasodilatation was observed with a magnitude of
+10.9\% +/- 14.9 (p < 0.001), followed by an increasing vasoconstriction (after 4
min -12.0\% +/- 7.6; p = 0.004). One volunteer had no measurable conjunctival
vessels in the baseline measurements and was therefore excluded from the study.
DISCUSSION: The suggested technique allows the measurement of changes in
conjunctival vessel diameter with high precision. The method represents a non
invasive technique for the assessment of effects on conjunctival vessels caused
by topical or systemic drugs.
%0 Journal Article
%1 Nagel.2003
%A Nagel, E.
%A Vilser, W.
%A Lanzl, I. M.
%D 2003
%J Clinical hemorheology and microcirculation
%K (Vasoconstrictor 0 Aged;Online Agents);Adult;Conjunctiva/*blood Agents/administration Systems;*Ophthalmoscopes;Ophthalmoscopy/methods;Retinal Vessels;Software;Vasoconstriction;Vasoconstrictor WViCo dosage/pharmacology;Vasodilation supply;Humans;Microcirculation;Middle {\&}
%N 4
%P 221--227
%T Online human conjunctival vessel diameter analysis. A clinical-methodical study
%V 28
%X BACKGROUND: The present study investigates the possible application of a
commercially available on-line measuring device of retinal vessels for
conjunctival vessel assessment. METHODS: Repeated measurements in one randomly
chosen eye were performed in 11 healthy volunteers (mean age 42.9 +/- 10 years).
Measurements of one conjunctival vessel were obtained first without a stimulus
followed by measurements after the application of one drop of a topical
vasoconstrictor. The examinations were performed by Retinal Vessel Analyzer (RVA,
IMEDOS/Germany). This system determines automatically on-line the vessel diameter
along a chosen vessel segment. RESULTS: Measurements in the native state without
eye drop application showed an intraclass correlation coefficient of 0.97 and a
mean variation coefficient of 1.8\%. After application of the topical
vasoconstrictor a short acting vasodilatation was observed with a magnitude of
+10.9\% +/- 14.9 (p < 0.001), followed by an increasing vasoconstriction (after 4
min -12.0\% +/- 7.6; p = 0.004). One volunteer had no measurable conjunctival
vessels in the baseline measurements and was therefore excluded from the study.
DISCUSSION: The suggested technique allows the measurement of changes in
conjunctival vessel diameter with high precision. The method represents a non
invasive technique for the assessment of effects on conjunctival vessels caused
by topical or systemic drugs.
@article{Nagel.2003,
abstract = {BACKGROUND: The present study investigates the possible application of a
commercially available on-line measuring device of retinal vessels for
conjunctival vessel assessment. METHODS: Repeated measurements in one randomly
chosen eye were performed in 11 healthy volunteers (mean age 42.9 +/- 10 years).
Measurements of one conjunctival vessel were obtained first without a stimulus
followed by measurements after the application of one drop of a topical
vasoconstrictor. The examinations were performed by Retinal Vessel Analyzer (RVA,
IMEDOS/Germany). This system determines automatically on-line the vessel diameter
along a chosen vessel segment. RESULTS: Measurements in the native state without
eye drop application showed an intraclass correlation coefficient of 0.97 and a
mean variation coefficient of 1.8{\%}. After application of the topical
vasoconstrictor a short acting vasodilatation was observed with a magnitude of
+10.9{\%} +/- 14.9 (p < 0.001), followed by an increasing vasoconstriction (after 4
min -12.0{\%} +/- 7.6; p = 0.004). One volunteer had no measurable conjunctival
vessels in the baseline measurements and was therefore excluded from the study.
DISCUSSION: The suggested technique allows the measurement of changes in
conjunctival vessel diameter with high precision. The method represents a non
invasive technique for the assessment of effects on conjunctival vessels caused
by topical or systemic drugs.},
added-at = {2013-10-10T21:29:09.000+0200},
author = {Nagel, E. and Vilser, W. and Lanzl, I. M.},
biburl = {https://www.bibsonomy.org/bibtex/22c1a718f0bcf242cbcf0bdd3546bfad9/imedos},
interhash = {42e2df126b417c6f66cd206522c1f479},
intrahash = {2c1a718f0bcf242cbcf0bdd3546bfad9},
issn = {1386-0291},
journal = {Clinical hemorheology and microcirculation},
keywords = {(Vasoconstrictor 0 Aged;Online Agents);Adult;Conjunctiva/*blood Agents/administration Systems;*Ophthalmoscopes;Ophthalmoscopy/methods;Retinal Vessels;Software;Vasoconstriction;Vasoconstrictor WViCo dosage/pharmacology;Vasodilation supply;Humans;Microcirculation;Middle {\&}},
number = 4,
pages = {221--227},
timestamp = {2013-10-11T01:11:02.000+0200},
title = {Online human conjunctival vessel diameter analysis. A clinical-methodical study},
volume = 28,
year = 2003
}