The IUPS Physiome Project: a framework for computational physiology.
P. Hunter. Prog. Biophys. Mol. Biol.85 (2-3):
The IUPS Physiome Project is an internationally collaborative open-source
project to provide a public domain framework for computational physiology,
including the development of modelling standards, computational tools
and web-accessible databases of models of structure and function
at all spatial scales. A number of papers in this volume deal with
the development of specific mathematical models of physiological
processes. This paper stands back from the detail of individual models
and reviews the current state of the IUPS Physiome Project including
organ and organ system continuum models, the interpretation of constitutive
law parameters in terms of micro-structural models, and markup languages
for standardizing cellular processes. Some current practical applications
of the physiome models are given and some of the challenges for the
next 5 years of the Physiome Project at the level of organs, cells
and proteins are proposed.