Smart package solutions may support a patient in the intake of medication---for instance, through the package's form factor or by linking of the package with digital data and services built upon these data. This chapter discusses the application potential of a so-called digital product memory in this domain. The starting point is a visionary scenario in which the interplay of intelligent environments and medicine packages equipped with digital product memories allows for unobtrusive support of a patient in dealing with situations that might affect his or her therapy compliance. In this chapter, components of a technical infrastructure of particular relevance to the envisioned kind of support are described. This discussion is complemented with a review of prototype implementations of interaction mechanisms taken from the scenario.