%0 Journal Article %1 soto2005comparative %A Soto, K. F. %A Carrasco, A. %A Powell, T. G. %A Garza, K. M. %A Murr, L. E. %D 2005 %I Springer Netherlands %J Journal of Nanoparticle Research %K cell nanoparticles phd %P 145--169 %R 10.1007/s11051-005-3473-1 %T Comparative in vitro cytotoxicity assessment of some manufacturednanoparticulate materials characterized by transmissionelectron microscopy %U http://dx.doi.org/10.1007/s11051-005-3473-1 %V 7 %X A range of manufactured nanoparticulate materials, including Ag, TiO 2 , Fe 2 O 3 , Al 2 O 3 , ZrO 2 , Si 3 N 4 , and a range of carbonaceous nanoparticulate materials: single-wall and multi-wall carbon nanotube aggregates and aggregated nanoparticles of black carbon, as well as commercial (mineral grade) chrysotile asbestos nanotube aggregates, have been rigorously characterized by transmission electron microscopy. These nanoparticulate materials ranged in primary particle sizes from roughly 3 to 150 nm (except for the nanotube materials with lengths in excess of 15 μm). Aggregate sizes ranged from 25 nm to 20 μm. Comparative cytotoxicological assessment of these nanomaterials was performed utilizing a murine (lung) macrophage cell line. Considering the chrysotile asbestos to be a positive control, and assigning it a relative cytotoxicity index of unity (1.0), relative cytotoxicity indexes were observed as follows at concentrations of 5 μg/ml: 1.6 and ∼ 0.4 for Ag and TiO 2 , respectively; 0.7–0.9 for the Fe 2 O 3 , Al 2 O 3 and ZrO 2 , 0.4 for the Si 3 N 4 , 0.8 for the black carbon, and 0.9 to 1.1 for the carbon nanotube aggregate samples. Observations of a cytotoxic response, nearly identical to that for chrysotile asbestos, for multi-wall carbon nanotube aggregates which very closely resemble anthropogenic multi-wall carbon nanotubes in the environment, raise some concern for potential health effects, especially for long-term exposure.

@article{soto2005comparative, abstract = {A range of manufactured nanoparticulate materials, including Ag, TiO 2 , Fe 2 O 3 , Al 2 O 3 , ZrO 2 , Si 3 N 4 , and a range of carbonaceous nanoparticulate materials: single-wall and multi-wall carbon nanotube aggregates and aggregated nanoparticles of black carbon, as well as commercial (mineral grade) chrysotile asbestos nanotube aggregates, have been rigorously characterized by transmission electron microscopy. These nanoparticulate materials ranged in primary particle sizes from roughly 3 to 150 nm (except for the nanotube materials with lengths in excess of 15 μm). Aggregate sizes ranged from 25 nm to 20 μm. Comparative cytotoxicological assessment of these nanomaterials was performed utilizing a murine (lung) macrophage cell line. Considering the chrysotile asbestos to be a positive control, and assigning it a relative cytotoxicity index of unity (1.0), relative cytotoxicity indexes were observed as follows at concentrations of 5 μg/ml: 1.6 and ∼ 0.4 for Ag and TiO 2 , respectively; 0.7–0.9 for the Fe 2 O 3 , Al 2 O 3 and ZrO 2 , 0.4 for the Si 3 N 4 , 0.8 for the black carbon, and 0.9 to 1.1 for the carbon nanotube aggregate samples. Observations of a cytotoxic response, nearly identical to that for chrysotile asbestos, for multi-wall carbon nanotube aggregates which very closely resemble anthropogenic multi-wall carbon nanotubes in the environment, raise some concern for potential health effects, especially for long-term exposure.}, added-at = {2011-12-06T11:52:16.000+0100}, affiliation = {Department of Metallurgical and Materials Engineering The University of Texas at El Paso El Paso TX 79968 USA}, author = {Soto, K. F. and Carrasco, A. and Powell, T. G. and Garza, K. M. and Murr, L. E.}, biburl = {https://www.bibsonomy.org/bibtex/2312db0b8c4e491490f5e4183cc8459f7/bkoch}, description = {SpringerLink - Journal of Nanoparticle Research, Volume 7, Numbers 2-3}, doi = {10.1007/s11051-005-3473-1}, interhash = {c22e64895c5949985290f3312d0f658a}, intrahash = {312db0b8c4e491490f5e4183cc8459f7}, issn = {1388-0764}, issue = {2}, journal = {Journal of Nanoparticle Research}, keyword = {Physics and Astronomy}, keywords = {cell nanoparticles phd}, pages = {145--169}, publisher = {Springer Netherlands}, timestamp = {2011-12-13T08:34:18.000+0100}, title = {Comparative in vitro cytotoxicity assessment of some manufacturednanoparticulate materials characterized by transmissionelectron microscopy}, url = {http://dx.doi.org/10.1007/s11051-005-3473-1}, volume = 7, year = 2005 }