Subfunctionalization: How often does it occur? How long does it take?
Theoretical Population Biology, 66 (2):
93--100 (September 2004)DOI: 10.1016/j.tpb.2004.03.004
Zusammenfassung
The mechanisms responsible for the preservation of duplicate genes have been debated for more than 70 years. Recently, Lynch and Force have proposed a new explanation: subfunctionalization—after duplication the two gene copies specialize to perform complementary functions. We investigate the probability that subfunctionalization occurs, the amount of time after duplication that it takes for the outcome to be resolved, and the relationship of these quantities to the population size and mutation rates.