%0 Journal Article %1 Yi2013 %A Yi, Jing %A Xu, Zhuwei %A Zhuang, Ran %A Wang, Jiuping %A Zhang, Yusi %A Ma, Ying %A Liu, Bei %A Zhang, Yun %A Zhang, Chunmei %A Yan, Guolin %A Zhang, Fanglin %A Xu, Zhikai %A Yang, Angang %A Jin, Boquan %D 2013 %J J Infect Dis %K virus %N 9 %P 1457--1461 %R 10.1093/infdis/jis475 %T Hantaan virus RNA load in patients having hemorrhagic fever with renal syndrome: correlation with disease severity. %U http://dx.doi.org/10.1093/infdis/jis475 %V 207 %X To investigate the role of viral load in the pathogenesis of hemorrhagic fever with renal syndrome, the Hantaan virus RNA load in plasma from 101 patients was quantified, and the relationships between viral load and disease course, severity, and level of specific humoral immunity were analyzed. The viral load, detectable in 79 patients, ranged from 3.43 to 7.33 log10 copies/mL of plasma. In the early stage of disease, patients in severe/critical group were found to have higher viral loads than those in the mild/moderate group (5.90 vs 5.03 log10 copies/mL; P = .001), suggesting an association between Hantaan virus load and disease severity.

@article{Yi2013, abstract = {To investigate the role of viral load in the pathogenesis of hemorrhagic fever with renal syndrome, the Hantaan virus RNA load in plasma from 101 patients was quantified, and the relationships between viral load and disease course, severity, and level of specific humoral immunity were analyzed. The viral load, detectable in 79 patients, ranged from 3.43 to 7.33 log10 copies/mL of plasma. In the early stage of disease, patients in severe/critical group were found to have higher viral loads than those in the mild/moderate group (5.90 vs 5.03 log10 copies/mL; P = .001), suggesting an association between Hantaan virus load and disease severity.}, added-at = {2013-06-08T02:14:38.000+0200}, author = {Yi, Jing and Xu, Zhuwei and Zhuang, Ran and Wang, Jiuping and Zhang, Yusi and Ma, Ying and Liu, Bei and Zhang, Yun and Zhang, Chunmei and Yan, Guolin and Zhang, Fanglin and Xu, Zhikai and Yang, Angang and Jin, Boquan}, biburl = {https://www.bibsonomy.org/bibtex/2367649a1e3995abd5fd8719fa92bd757/aorchid}, description = {look at viral log level in blood and find higher early levels in more severe group. This group also has some work looking at antigenic epitopes for the disease. Have in paper from JID.}, doi = {10.1093/infdis/jis475}, groups = {public}, institution = {Department of Immunology, Xijing Hospital, Xi’an, China.}, interhash = {4e91166e92bbf6b6572b88659c7475d7}, intrahash = {367649a1e3995abd5fd8719fa92bd757}, journal = {J Infect Dis}, keywords = {virus}, language = {eng}, medline-pst = {ppublish}, month = May, number = 9, pages = {1457--1461}, pii = {jis475}, pmid = {22869912}, timestamp = {2013-06-08T02:14:38.000+0200}, title = {Hantaan virus RNA load in patients having hemorrhagic fever with renal syndrome: correlation with disease severity.}, url = {http://dx.doi.org/10.1093/infdis/jis475}, username = {aorchid}, volume = 207, year = 2013 }