%0 Journal Article %1 Kittler2010 %A Kittler, S. %A Greulich, C. %A Diendorf, J. %A Köller, M. %A Epple, M. %D 2010 %J Chemistry of Materials %K nanoparticles silver toxicity %N 16 %P 4548–4554 %R 10.1021/cm100023p %T Toxicity of Silver Nanoparticles Increases during Storage Because of Slow Dissolution under Release of Silver Ions %U http://dx.doi.org/10.1021/cm100023p %V 22 %X The dissolution of citrate-stabilized and poly(vinylpyrrolidone)-stabilized silver nanoparticles in water was studied by dialysis for up to 125 days at 5, 25, and 37 °C. The particles slowly dissolve into ions on a time scale of several days. However, in all cases, a limiting value of the released silver was observed, i.e., the particles did not completely dissolve. In some cases, the nanoparticles released up to 90\% of their weight. Formal kinetic data were computed. Rate and degree of dissolution depended on the functionalization as well as on the storage temperature. The release of silver led to a considerably increased toxicity of silver nanoparticles which had been stored in dispersion for several weeks toward human mesenchymal stem cells due to the increased concentration of silver ions. Consequently, �? aged�? (i.e., immersed) silver nanoparticles are much more toxic to cells than freshly prepared silver nanoparticles.

@article{Kittler2010, abstract = {The dissolution of citrate-stabilized and poly(vinylpyrrolidone)-stabilized silver nanoparticles in water was studied by dialysis for up to 125 days at 5, 25, and 37 °C. The particles slowly dissolve into ions on a time scale of several days. However, in all cases, a limiting value of the released silver was observed, i.e., the particles did not completely dissolve. In some cases, the nanoparticles released up to 90\% of their weight. Formal kinetic data were computed. Rate and degree of dissolution depended on the functionalization as well as on the storage temperature. The release of silver led to a considerably increased toxicity of silver nanoparticles which had been stored in dispersion for several weeks toward human mesenchymal stem cells due to the increased concentration of silver ions. Consequently, �? aged�? (i.e., immersed) silver nanoparticles are much more toxic to cells than freshly prepared silver nanoparticles.}, added-at = {2011-10-01T00:26:04.000+0200}, author = {Kittler, S. and Greulich, C. and Diendorf, J. and Köller, M. and Epple, M.}, biburl = {https://www.bibsonomy.org/bibtex/23a3875db79ce02e5bf226c2899ea4631/afcallender}, citeulike-article-id = {7591538}, citeulike-linkout-0 = {http://dx.doi.org/10.1021/cm100023p}, citeulike-linkout-1 = {http://pubs.acs.org/doi/abs/10.1021/cm100023p}, doi = {10.1021/cm100023p}, file = {Kittler2010.pdf:indexed\\Kittler2010.pdf:PDF}, groups = {public}, interhash = {3ffc7d7be972694145b1a48bb00e9da6}, intrahash = {3a3875db79ce02e5bf226c2899ea4631}, journal = {Chemistry of Materials}, keywords = {nanoparticles silver toxicity}, number = 16, pages = {4548–4554}, posted-at = {2010-08-09 04:56:52}, priority = {2}, timestamp = {2011-10-01T00:26:04.000+0200}, title = {Toxicity of Silver Nanoparticles Increases during Storage Because of Slow Dissolution under Release of Silver Ions}, url = {http://dx.doi.org/10.1021/cm100023p}, username = {afcallender}, volume = 22, year = 2010 }