%0 Journal Article %1 taha_circumvention_2001 %A Taha, M K %A Bichier, E %A Perrocheau, A %A Alonso, J M %D 2001 %J Infection and Immunity %K Analysis, Chain Data, Disease Epidemiology, France, Humans, Infections, Meningococcal Molecular Molecular, Mutation, Neisseria Outbreaks, Polymerase Porins, Reaction, Sequence Vaccines, meningitidis, {DNA} %N 3 %P 1971--1973 %R 10.1128/IAI.69.3.1971-1973.2001 %T Circumvention of herd immunity during an outbreak of meningococcal disease could be correlated to escape mutation in the porA gene of Neisseria meningitidis %U http://www.ncbi.nlm.nih.gov/pubmed/11179386 %V 69 %X Meningococcal strains isolated during an outbreak were shown to belong to the ET-5 complex and to harbor a mutation in the VR2 region of the porA gene. They were less susceptible to the bactericidal effect of normal human serum than was the ET-5 wild-type strain. These results are of concern, as PorA is a potential target in vaccine design.

@article{taha_circumvention_2001, abstract = {Meningococcal strains isolated during an outbreak were shown to belong to the {ET-5} complex and to harbor a mutation in the {VR2} region of the {porA} gene. They were less susceptible to the bactericidal effect of normal human serum than was the {ET-5} wild-type strain. These results are of concern, as {PorA} is a potential target in vaccine design.}, added-at = {2011-03-11T10:05:34.000+0100}, author = {Taha, M K and Bichier, E and Perrocheau, A and Alonso, J M}, biburl = {https://www.bibsonomy.org/bibtex/20d0d65c1c617415165a82986662809f8/jelias}, doi = {10.1128/IAI.69.3.1971-1973.2001}, interhash = {23b7493ebef7e7a4fddf7ec7c70aabc6}, intrahash = {0d0d65c1c617415165a82986662809f8}, issn = {0019-9567}, journal = {Infection and Immunity}, keywords = {Analysis, Chain Data, Disease Epidemiology, France, Humans, Infections, Meningococcal Molecular Molecular, Mutation, Neisseria Outbreaks, Polymerase Porins, Reaction, Sequence Vaccines, meningitidis, {DNA}}, month = mar, note = {{PMID:} 11179386}, number = 3, pages = {1971--1973}, timestamp = {2011-03-11T10:06:15.000+0100}, title = {Circumvention of herd immunity during an outbreak of meningococcal disease could be correlated to escape mutation in the {porA} gene of Neisseria meningitidis}, url = {http://www.ncbi.nlm.nih.gov/pubmed/11179386}, volume = 69, year = 2001 }