%0 Journal Article %1 Jhaveri:2018:Cancer:29205287 %A Jhaveri, J %A Liu, Y %A Chowdhary, M %A Buchwald, Z S %A Gillespie, T W %A Olson, J J %A Voloschin, A D %A Eaton, B R %A Shu, H G %A Crocker, I R %A Curran, W J %A Patel, K R %D 2018 %J Cancer %K cancer-research glioma paywall survival %N 6 %P 1169-1178 %R 10.1002/cncr.31158 %T Is less more? Comparing chemotherapy alone with chemotherapy and radiation for high-risk grade 2 glioma: An analysis of the National Cancer Data Base %U https://www.ncbi.nlm.nih.gov/pubmed/29205287 %V 124 %X The addition of chemotherapy to adjuvant radiotherapy (chemotherapy and radiation therapy CRT) improves overall survival (OS) for patients with high-risk grade 2 gliomas; however, the impact of chemotherapy alone (CA) is unknown. This study compares the OS of patients with high-risk grade 2 gliomas treated with CA versus CRT.Patients with high-risk grade 2 gliomas (subtotal resection or age ≥ 40 years) with oligodendrogliomas, astrocytomas, or mixed tumors were identified with the National Cancer Data Base. Patients were grouped into CA and CRT cohorts. Univariate analyses and multivariate analyses (MVAs) were performed. Propensity score (PS) matching was also implemented. The Kaplan-Meier method was used to analyze OS.A total of 1054 patients with high-risk grade 2 gliomas were identified: 496 (47.1%) received CA, and 558 (52.9%) received CRT. Patients treated with CA were more likely (all P values  6 cm, astrocytoma histology, and older age were predictors for worse OS (all P values < .05). After 1:1 PS matching (n = 331 for each cohort), no OS difference was seen (P = .696) between the CA and CRT cohorts at 5 (69.3% vs 67.4%) and 8 years (52.8% vs 56.7%).No long-term OS difference was seen in patients with high-risk grade 2 gliomas treated with CA versus CRT. These findings are hypothesis-generating, and prospective clinical trials comparing these treatment paradigms are warranted. Cancer 2018;124:1169-78. © 2017 American Cancer Society.

@article{Jhaveri:2018:Cancer:29205287, abstract = {The addition of chemotherapy to adjuvant radiotherapy (chemotherapy and radiation therapy [CRT]) improves overall survival (OS) for patients with high-risk grade 2 gliomas; however, the impact of chemotherapy alone (CA) is unknown. This study compares the OS of patients with high-risk grade 2 gliomas treated with CA versus CRT.Patients with high-risk grade 2 gliomas (subtotal resection or age ≥ 40 years) with oligodendrogliomas, astrocytomas, or mixed tumors were identified with the National Cancer Data Base. Patients were grouped into CA and CRT cohorts. Univariate analyses and multivariate analyses (MVAs) were performed. Propensity score (PS) matching was also implemented. The Kaplan-Meier method was used to analyze OS.A total of 1054 patients with high-risk grade 2 gliomas were identified: 496 (47.1%) received CA, and 558 (52.9%) received CRT. Patients treated with CA were more likely (all P values  6 cm, astrocytoma histology, and older age were predictors for worse OS (all P values < .05). After 1:1 PS matching (n = 331 for each cohort), no OS difference was seen (P = .696) between the CA and CRT cohorts at 5 (69.3% vs 67.4%) and 8 years (52.8% vs 56.7%).No long-term OS difference was seen in patients with high-risk grade 2 gliomas treated with CA versus CRT. These findings are hypothesis-generating, and prospective clinical trials comparing these treatment paradigms are warranted. Cancer 2018;124:1169-78. © 2017 American Cancer Society.}, added-at = {2018-05-18T23:14:52.000+0200}, author = {Jhaveri, J and Liu, Y and Chowdhary, M and Buchwald, Z S and Gillespie, T W and Olson, J J and Voloschin, A D and Eaton, B R and Shu, H G and Crocker, I R and Curran, W J and Patel, K R}, biburl = {https://www.bibsonomy.org/bibtex/24d1afefb367937bf198dcd1fd5cee531/marcsaric}, description = {Is less more? Comparing chemotherapy alone with chemotherapy and radiation for high-risk grade 2 glioma: An analysis of the National Cancer Data Base. - PubMed - NCBI}, doi = {10.1002/cncr.31158}, interhash = {040d8cd08f7519f684bc27f40cc3d738}, intrahash = {4d1afefb367937bf198dcd1fd5cee531}, journal = {Cancer}, keywords = {cancer-research glioma paywall survival}, month = mar, number = 6, pages = {1169-1178}, pmid = {29205287}, timestamp = {2018-05-18T23:15:31.000+0200}, title = {Is less more? Comparing chemotherapy alone with chemotherapy and radiation for high-risk grade 2 glioma: An analysis of the National Cancer Data Base}, url = {https://www.ncbi.nlm.nih.gov/pubmed/29205287}, volume = 124, year = 2018 }