%0 Journal Article %1 granoff_relative_2009 %A Granoff, Dan M %D 2009 %J Vaccine %K Animals, Antibodies, Bacterial, Child, Complement Humans, Infant, Infections, Meningococcal Microbial Neisseria Opsonin Phagocytosis Preschool, Proteins, System Viability, meningitidis, %P B117--125 %R 10.1016/j.vaccine.2009.04.066 %T Relative importance of complement-mediated bactericidal and opsonic activity for protection against meningococcal disease %U http://www.ncbi.nlm.nih.gov/pubmed/19477054 %V 27 Suppl 2 %X Killing of Neisseria meningitidis can result from complement-mediated serum bactericidal activity (SBA) or opsonophagocytosis (OPA), or a combination of the two mechanisms. While SBA titers \textgreater or =1:4 confer protection, recent evidence suggests that this threshold titer may not be required. For example, the incidence of meningococcal disease declines between ages 1 and 4 years without evidence of acquisition of SBA titers \textgreater or =1:4. Meningococcal polysaccharide vaccination also elicited OPA and lowered the risk of disease in patients with late complement component deficiencies whose sera did not support SBA. Sera from healthy adults immunized with an outer membrane vesicle vaccine showed OPA killing of N. meningitidis with C6-depleted complement, and whole blood from complement-sufficient non-immunized adults with SBA titers \textless1:4 also frequently had killing activity. Collectively the data indicate that SBA titers \textless1:4 and/or vaccine-induced OPA can confer protection against meningococcal disease.

@article{granoff_relative_2009, abstract = {Killing of Neisseria meningitidis can result from complement-mediated serum bactericidal activity {(SBA)} or opsonophagocytosis {(OPA),} or a combination of the two mechanisms. While {SBA} titers {\textgreater} or =1:4 confer protection, recent evidence suggests that this threshold titer may not be required. For example, the incidence of meningococcal disease declines between ages 1 and 4 years without evidence of acquisition of {SBA} titers {\textgreater} or =1:4. Meningococcal polysaccharide vaccination also elicited {OPA} and lowered the risk of disease in patients with late complement component deficiencies whose sera did not support {SBA.} Sera from healthy adults immunized with an outer membrane vesicle vaccine showed {OPA} killing of N. meningitidis with C6-depleted complement, and whole blood from complement-sufficient non-immunized adults with {SBA} titers {\textless}1:4 also frequently had killing activity. Collectively the data indicate that {SBA} titers {\textless}1:4 and/or vaccine-induced {OPA} can confer protection against meningococcal disease.}, added-at = {2011-03-11T10:05:34.000+0100}, author = {Granoff, Dan M}, biburl = {https://www.bibsonomy.org/bibtex/250b0be34a939dc5725198cfab73aabd5/jelias}, doi = {10.1016/j.vaccine.2009.04.066}, interhash = {69c25b509be2529b99c015027f306b69}, intrahash = {50b0be34a939dc5725198cfab73aabd5}, issn = {1873-2518}, journal = {Vaccine}, keywords = {Animals, Antibodies, Bacterial, Child, Complement Humans, Infant, Infections, Meningococcal Microbial Neisseria Opsonin Phagocytosis Preschool, Proteins, System Viability, meningitidis,}, month = jun, note = {{PMID:} 19477054}, pages = {B117--125}, timestamp = {2011-03-11T10:06:10.000+0100}, title = {Relative importance of complement-mediated bactericidal and opsonic activity for protection against meningococcal disease}, url = {http://www.ncbi.nlm.nih.gov/pubmed/19477054}, volume = {27 Suppl 2}, year = 2009 }