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Study of the Effect of Ginkgo Biloba Leaf Extracts on the Activity of Cardiac Enzymes LDH, CK-MB using Spectroscopic Methods

. CENTRAL ASIAN JOURNAL OF MEDICAL AND NATURAL SCIENCE, 4 (5): 891-902 (September 2023)

Abstract

Acute cessation of coronary blood flow leads to myocardial necrosis, which is referred to as myocardial infarction (MI). Myocardial infarction always occurs due to atherosclerosis. The present study is designed to investigate cardiac effects from aqueous and alcoholic ginkgo leaf extracts on human serum in patients with myocardial infarction. This study was conducted between December 2021 and March 2022. Clinical tests included the inclusion of (60) patients diagnosed with myocardial disease and (40) others who were in good health as an officer group. The serum of these samples was analyzed for activity (ALP, AST, ALT, LDH, and CK-MB) using spectroscopy methods. Then the extracts of Ginkgo Biloba leaves (aqueous and alcoholic) were applied to each patient's serum and the LDH, and the CK-MB inhibition ratio was measured to verify their effects, and the results showed a rise in the activity of the five enzymes of myocardial infarction patients, with good inhibition rates for both extractors on the effectiveness of enzymes (LDH, CK-MB) and the type of inhibition was non-competitive. SPSS-26 was used for intermediate comparisons by independent t-test.

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