The mitochondrial inner membrane harbors the complexes of the respiratory chain and translocase complexes for precursor proteins. We have identified a further subunit of the carrier translocase (TIM22 complex) that surprisingly is identical to subunit 3 of respiratory complex II, succinate dehydrogenase (Sdh3). The membrane-integral protein Sdh3 plays specific functions in electron transfer in complex II. We show by genetic and biochemical approaches that Sdh3 also plays specific functions in the TIM22 complex. Sdh3 forms a subcomplex with Tim18 and is involved in biogenesis and assembly of the membrane-integral subunits of the TIM22 complex. We conclude that the assembly of Sdh3 with different partner proteins, Sdh4 and Tim18, recruits it to two different mitochondrial membrane complexes with functions in bioenergetics and protein biogenesis, respectively.
%0 Journal Article
%1 gebertDualFunctionSdh32011
%A Gebert, Natalia
%A Gebert, Michael
%A Oeljeklaus, Silke
%A von der Malsburg, Karina
%A Stroud, David A.
%A Kulawiak, Bogusz
%A Wirth, Christophe
%A Zahedi, René P.
%A Dolezal, Pavel
%A Wiese, Sebastian
%A Simon, Oliver
%A Schulze-Specking, Agnes
%A Truscott, Kaye N.
%A Sickmann, Albert
%A Rehling, Peter
%A Guiard, Bernard
%A Hunte, Carola
%A Warscheid, Bettina
%A van der Laan, Martin
%A Pfanner, Nikolaus
%A Wiedemann, Nils
%C United States
%D 2011
%J Molecular cell
%K *Electron Complex Dehydrogenase/*metabolism,to_read II/metabolism,Mitochondrial Import Membrane Membranes/enzymology/*metabolism,Mitochondrial Precursor Protein Proteins,Saccharomyces Proteins/*metabolism,Mitochondrial Proteins/*metabolism,Saccharomyces Transport Transport,Electron cerevisiae cerevisiae/cytology/enzymology/*metabolism,Succinate
%N 5
%P 811--818
%R 10.1016/j.molcel.2011.09.025
%T Dual Function of Sdh3 in the Respiratory Chain and TIM22 Protein Translocase of the Mitochondrial Inner Membrane.
%V 44
%X The mitochondrial inner membrane harbors the complexes of the respiratory chain and translocase complexes for precursor proteins. We have identified a further subunit of the carrier translocase (TIM22 complex) that surprisingly is identical to subunit 3 of respiratory complex II, succinate dehydrogenase (Sdh3). The membrane-integral protein Sdh3 plays specific functions in electron transfer in complex II. We show by genetic and biochemical approaches that Sdh3 also plays specific functions in the TIM22 complex. Sdh3 forms a subcomplex with Tim18 and is involved in biogenesis and assembly of the membrane-integral subunits of the TIM22 complex. We conclude that the assembly of Sdh3 with different partner proteins, Sdh4 and Tim18, recruits it to two different mitochondrial membrane complexes with functions in bioenergetics and protein biogenesis, respectively.
@article{gebertDualFunctionSdh32011,
abstract = {The mitochondrial inner membrane harbors the complexes of the respiratory chain and translocase complexes for precursor proteins. We have identified a further subunit of the carrier translocase (TIM22 complex) that surprisingly is identical to subunit 3 of respiratory complex II, succinate dehydrogenase (Sdh3). The membrane-integral protein Sdh3 plays specific functions in electron transfer in complex II. We show by genetic and biochemical approaches that Sdh3 also plays specific functions in the TIM22 complex. Sdh3 forms a subcomplex with Tim18 and is involved in biogenesis and assembly of the membrane-integral subunits of the TIM22 complex. We conclude that the assembly of Sdh3 with different partner proteins, Sdh4 and Tim18, recruits it to two different mitochondrial membrane complexes with functions in bioenergetics and protein biogenesis, respectively.},
added-at = {2024-05-17T13:01:35.000+0200},
address = {United States},
author = {Gebert, Natalia and Gebert, Michael and Oeljeklaus, Silke and {von der Malsburg}, Karina and Stroud, David A. and Kulawiak, Bogusz and Wirth, Christophe and Zahedi, Ren{\'e} P. and Dolezal, Pavel and Wiese, Sebastian and Simon, Oliver and {Schulze-Specking}, Agnes and Truscott, Kaye N. and Sickmann, Albert and Rehling, Peter and Guiard, Bernard and Hunte, Carola and Warscheid, Bettina and {van der Laan}, Martin and Pfanner, Nikolaus and Wiedemann, Nils},
biburl = {https://www.bibsonomy.org/bibtex/260f95901a7c3f9fa9f2b4f0de125d502/warscheidlab},
copyright = {Copyright {\copyright} 2011 Elsevier Inc. All rights reserved.},
doi = {10.1016/j.molcel.2011.09.025},
interhash = {8f91ea6bdfe99085f3669ecef8d5838f},
intrahash = {60f95901a7c3f9fa9f2b4f0de125d502},
issn = {1097-4164 1097-2765},
journal = {Molecular cell},
keywords = {*Electron Complex Dehydrogenase/*metabolism,to_read II/metabolism,Mitochondrial Import Membrane Membranes/enzymology/*metabolism,Mitochondrial Precursor Protein Proteins,Saccharomyces Proteins/*metabolism,Mitochondrial Proteins/*metabolism,Saccharomyces Transport Transport,Electron cerevisiae cerevisiae/cytology/enzymology/*metabolism,Succinate},
langid = {english},
month = dec,
number = 5,
pages = {811--818},
pmid = {22152483},
timestamp = {2024-05-17T13:01:35.000+0200},
title = {Dual Function of {{Sdh3}} in the Respiratory Chain and {{TIM22}} Protein Translocase of the Mitochondrial Inner Membrane.},
volume = 44,
year = 2011
}