%0 Journal Article %1 L'Abee2005 %A L'Abee, Carianne %A de Vries, Linda S %A van der Grond, Jeroen %A Groenendaal, Floris %D 2005 %J Biol Neonate %K Asphyxia Neonatorum; Brain; Cerebral Palsy; Electroencephalography; Gestational Age; Humans; Hydrogen-Ion Concentration; Hypoxia-Ischemia, Infant, Newborn; Magnetic Resonance Imaging; Spectroscopy; Prognosis; Umbilical Arteries %N 4 %P 306--312 %R 10.1159/000087628 %T Early diffusion-weighted MRI and 1H-Magnetic Resonance Spectroscopy in asphyxiated full-term neonates. %U http://dx.doi.org/10.1159/000087628 %V 88 %X AIM: To assess the predictive value of early MRI and proton MR spectroscopy ((1)H-MRS), 11 full-term neonates with severe perinatal asphyxia were studied within 48 h after birth. METHODS: T(1)- and T(2)-weighted MRI, diffusion-weighted MRI (DW-MRI), apparent diffusion coefficient of water (ADC) of the basal ganglia and parietal white matter, as well as (1)H-MRS of the basal ganglia were performed in a 1.5-Tesla magnetic field. Neurodevelopment was assessed in the survivors for at least 24 months. RESULTS: Nine of the 11 neonates had a poor outcome (7 died, 2 developed cerebral palsy). All examinations were normal in the 2 neonates with a good outcome. T(1)- and T(2)-weighted MRI were abnormal in 7, DWI was abnormal in 7, ADC was abnormal in 5, and elevated lactate/N-acetylaspartate ratios using (1)H-MRS were seen in 7 of the 9 neonates with a poor outcome. None of these 9 had completely normal MRI or (1)H-MRS findings. CONCLUSIONS: Using a combination of T(1)- and T(2)-weighted MRI, DW-MRI, ADC measurements and (1)H-MRS within 48 h after severe perinatal asphyxia, no abnormalities were seen with any of these techniques in both neonates with a good outcome.

@article{L'Abee2005, abstract = {AIM: To assess the predictive value of early MRI and proton MR spectroscopy ((1)H-MRS), 11 full-term neonates with severe perinatal asphyxia were studied within 48 h after birth. METHODS: T(1)- and T(2)-weighted MRI, diffusion-weighted MRI (DW-MRI), apparent diffusion coefficient of water (ADC) of the basal ganglia and parietal white matter, as well as (1)H-MRS of the basal ganglia were performed in a 1.5-Tesla magnetic field. Neurodevelopment was assessed in the survivors for at least 24 months. RESULTS: Nine of the 11 neonates had a poor outcome (7 died, 2 developed cerebral palsy). All examinations were normal in the 2 neonates with a good outcome. T(1)- and T(2)-weighted MRI were abnormal in 7, DWI was abnormal in 7, ADC was abnormal in 5, and elevated lactate/N-acetylaspartate ratios using (1)H-MRS were seen in 7 of the 9 neonates with a poor outcome. None of these 9 had completely normal MRI or (1)H-MRS findings. CONCLUSIONS: Using a combination of T(1)- and T(2)-weighted MRI, DW-MRI, ADC measurements and (1)H-MRS within 48 h after severe perinatal asphyxia, no abnormalities were seen with any of these techniques in both neonates with a good outcome.}, added-at = {2014-07-19T20:40:14.000+0200}, author = {L'Abee, Carianne and de Vries, Linda S and van der Grond, Jeroen and Groenendaal, Floris}, biburl = {https://www.bibsonomy.org/bibtex/263aa70457335f24bf947b33ebf870f3e/ar0berts}, doi = {10.1159/000087628}, groups = {public}, interhash = {7e109a7b791ad741f108d67bcf60ee46}, intrahash = {63aa70457335f24bf947b33ebf870f3e}, journal = {Biol Neonate}, keywords = {Asphyxia Neonatorum; Brain; Cerebral Palsy; Electroencephalography; Gestational Age; Humans; Hydrogen-Ion Concentration; Hypoxia-Ischemia, Infant, Newborn; Magnetic Resonance Imaging; Spectroscopy; Prognosis; Umbilical Arteries}, number = 4, pages = {306--312}, pii = {BON2005088004306}, pmid = {16113525}, timestamp = {2014-07-19T20:40:14.000+0200}, title = {Early diffusion-weighted MRI and 1H-Magnetic Resonance Spectroscopy in asphyxiated full-term neonates.}, url = {http://dx.doi.org/10.1159/000087628}, username = {ar0berts}, volume = 88, year = 2005 }