Moulton DE, Goriely A. Possible role of differential growth in airway
wall remodeling in asthma. J Appl Physiol 110: 1003-1012, 2011. First
published January 20, 2011; doi:10.1152/japplphysiol.00991.2010.-Airway
remodeling in patients with chronic asthma is characterized by a
thickening of the airway walls. It has been demonstrated in previous
theoretical models that this change in thickness can have an important
mechanical effect on the properties of the wall, in particular on the
phenomenon of mucosal folding induced by smooth muscle contraction. In
this paper, we present a model for mucosal folding of the airway in the
context of growth. The airway is modeled as a bilayered cylindrical
tube, with both geometric and material nonlinearities accounted for via
the theory of finite elasticity. Growth is incorporated into the model
through the theory of morphoelasticity. We explore a range of growth
possibilities, allowing for anisotropic growth as well as different
growth rates in each layer. Such nonuniform growth, referred to as
differential growth, can change the properties of the material beyond
geometrical changes through the generation of residual stresses. We
demonstrate that differential growth can have a dramatic impact on
mucosal folding, in particular on the critical pressure needed to induce
folding, the buckling pattern, as well as airway narrowing. We conclude
that growth may be an important component in airway remodeling.
King Abdullah University of Science and Technology (KAUST)
KUK-C1-013-04; National Science Foundation DMS-0907773;
Wolfson/Royal Society
research-areas
Physiology; Sport Sciences
doc-delivery-number
748RD
number-of-cited-references
57
affiliation
Moulton, DE (Reprint Author), Univ Oxford, Inst Math, OCCAM, 24-29 St Giles, Oxford OX1 3LB, England..
Moulton, D. E.; Goriely, A., Univ Oxford, Inst Math, OCCAM, Oxford OX1 3LB, England.
web-of-science-categories
Physiology; Sport Sciences
language
English
funding-text
This publication is based on work supported by Award No. KUK-C1-013-04,
made by King Abdullah University of Science and Technology (KAUST), and
based in part upon work supported by the National Science Foundation
under grant DMS-0907773 (to A. Goriely). A. Goriely is a Wolfson/Royal
Society Merit Award holder.
%0 Journal Article
%1 mou-gor
%A Moulton, D. E.
%A Goriely, A.
%C 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
%D 2011
%I AMER PHYSIOLOGICAL SOC
%J JOURNAL OF APPLIED PHYSIOLOGY
%K asthma growth remodelling
%N 4
%P 1003-1012
%R 10.1152/japplphysiol.00991.2010
%T Possible role of differential growth in airway wall remodeling in asthma
%V 110
%X Moulton DE, Goriely A. Possible role of differential growth in airway
wall remodeling in asthma. J Appl Physiol 110: 1003-1012, 2011. First
published January 20, 2011; doi:10.1152/japplphysiol.00991.2010.-Airway
remodeling in patients with chronic asthma is characterized by a
thickening of the airway walls. It has been demonstrated in previous
theoretical models that this change in thickness can have an important
mechanical effect on the properties of the wall, in particular on the
phenomenon of mucosal folding induced by smooth muscle contraction. In
this paper, we present a model for mucosal folding of the airway in the
context of growth. The airway is modeled as a bilayered cylindrical
tube, with both geometric and material nonlinearities accounted for via
the theory of finite elasticity. Growth is incorporated into the model
through the theory of morphoelasticity. We explore a range of growth
possibilities, allowing for anisotropic growth as well as different
growth rates in each layer. Such nonuniform growth, referred to as
differential growth, can change the properties of the material beyond
geometrical changes through the generation of residual stresses. We
demonstrate that differential growth can have a dramatic impact on
mucosal folding, in particular on the critical pressure needed to induce
folding, the buckling pattern, as well as airway narrowing. We conclude
that growth may be an important component in airway remodeling.
@article{mou-gor,
abstract = {{Moulton DE, Goriely A. Possible role of differential growth in airway
wall remodeling in asthma. J Appl Physiol 110: 1003-1012, 2011. First
published January 20, 2011; doi:10.1152/japplphysiol.00991.2010.-Airway
remodeling in patients with chronic asthma is characterized by a
thickening of the airway walls. It has been demonstrated in previous
theoretical models that this change in thickness can have an important
mechanical effect on the properties of the wall, in particular on the
phenomenon of mucosal folding induced by smooth muscle contraction. In
this paper, we present a model for mucosal folding of the airway in the
context of growth. The airway is modeled as a bilayered cylindrical
tube, with both geometric and material nonlinearities accounted for via
the theory of finite elasticity. Growth is incorporated into the model
through the theory of morphoelasticity. We explore a range of growth
possibilities, allowing for anisotropic growth as well as different
growth rates in each layer. Such nonuniform growth, referred to as
differential growth, can change the properties of the material beyond
geometrical changes through the generation of residual stresses. We
demonstrate that differential growth can have a dramatic impact on
mucosal folding, in particular on the critical pressure needed to induce
folding, the buckling pattern, as well as airway narrowing. We conclude
that growth may be an important component in airway remodeling.}},
added-at = {2013-01-07T15:20:39.000+0100},
address = {{9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA}},
affiliation = {{Moulton, DE (Reprint Author), Univ Oxford, Inst Math, OCCAM, 24-29 St Giles, Oxford OX1 3LB, England..
Moulton, D. E.; Goriely, A., Univ Oxford, Inst Math, OCCAM, Oxford OX1 3LB, England.}},
author = {Moulton, D. E. and Goriely, A.},
author-email = {{moulton@maths.ox.ac.uk}},
biburl = {https://www.bibsonomy.org/bibtex/26771de135537ceeb5ebd7f88f0bee30e/jehiorns},
doc-delivery-number = {{748RD}},
doi = {{10.1152/japplphysiol.00991.2010}},
funding-acknowledgement = {{King Abdullah University of Science and Technology (KAUST)
{[}KUK-C1-013-04]; National Science Foundation {[}DMS-0907773];
Wolfson/Royal Society}},
funding-text = {{This publication is based on work supported by Award No. KUK-C1-013-04,
made by King Abdullah University of Science and Technology (KAUST), and
based in part upon work supported by the National Science Foundation
under grant DMS-0907773 (to A. Goriely). A. Goriely is a Wolfson/Royal
Society Merit Award holder.}},
interhash = {a647fb5f5231f1188b49b4b6d448c6e4},
intrahash = {6771de135537ceeb5ebd7f88f0bee30e},
issn = {{8750-7587}},
journal = {{JOURNAL OF APPLIED PHYSIOLOGY}},
journal-iso = {{J. Appl. Physiol.}},
keywords = {asthma growth remodelling},
keywords-plus = {{ZERO-STRESS STATE; BIOLOGICAL TISSUES; RESIDUAL-STRESSES; ELASTIC
TISSUES; SMOOTH-MUSCLE; MODEL; MECHANICS; BRONCHI; LUNG; INSTABILITY}},
language = {{English}},
month = {{APR}},
number = {{4}},
number-of-cited-references = {{57}},
pages = {{1003-1012}},
publisher = {{AMER PHYSIOLOGICAL SOC}},
research-areas = {{Physiology; Sport Sciences}},
researcherid-numbers = {{Goriely, Alain/E-3277-2012}},
times-cited = {{1}},
timestamp = {2013-01-07T15:20:39.000+0100},
title = {{Possible role of differential growth in airway wall remodeling in asthma}},
type = {{Article}},
unique-id = {{ISI:000289407500019}},
volume = {{110}},
web-of-science-categories = {{Physiology; Sport Sciences}},
year = {{2011}}
}