%0 Journal Article %1 Yehezkely-Schildkraut2005 %A Yehezkely-Schildkraut, Vered %A Kutai, Miriam %A Hugeirat, Yaser %A Levin, Carina %A Shalev, Stavit Alon %A Mazor, Galia %A Koren, Ariel %D 2005 %J Isr Med Assoc J %K Adolescent; Arabs; Case-Control Studies; Cerebral Palsy; Child; Child, Preschool; Factor V; Female; Humans; Infant; Israel; Jews; Male; Methylenetetrahydrofolate Dehydrogenase (NADP); Prothrombin; Risk Factors; Thrombophilia %N 12 %P 808--811 %T Thrombophilia: a risk factor for cerebral palsy? %V 7 %X BACKGROUND: The cause of cerebral palsy remains unknown in most cases. Factor V Leiden mutation, a common cause of hereditary thrombophilia, has been associated with CP. OBJECTIVES: To analyze the prevalence of factor V Leiden (G1691A), prothrombin (G20210A), and methylenetetrahydrofolate reductase (C677T) mutations in children with CP. METHODS: Sixty-one Jewish and Arab children with CP were studied for the presence of the three gene mutations associated with thrombophilia. RESULTS: We found that 41\% of the children with CP and 33\% of the controls carry one or more of the studied mutations (P = 0.348). The prevalence of the factor V mutation was 27.9\% in CP and 16.4\% in controls (P= 0.127). The frequency of the other two genetic factors was even less significant. The FVL mutation was found in 35\% of the Arab CP patients (15/42) and in 22\% of the controls from the same population (9/40) (P= 0.067). CONCLUSIONS: Each of the genetic factors studied was shown to be related to CP. Despite the high frequency of FVL among the studied patients, we were unable to prove a significant correlation between FVL and CP, mainly because this factor is frequent in the Arab control group. In this population a trend toward significance can be seen (P= 0.067). Larger studies are needed to validate the significance of these results.

@article{Yehezkely-Schildkraut2005, abstract = {BACKGROUND: The cause of cerebral palsy remains unknown in most cases. Factor V Leiden mutation, a common cause of hereditary thrombophilia, has been associated with CP. OBJECTIVES: To analyze the prevalence of factor V Leiden (G1691A), prothrombin (G20210A), and methylenetetrahydrofolate reductase (C677T) mutations in children with CP. METHODS: Sixty-one Jewish and Arab children with CP were studied for the presence of the three gene mutations associated with thrombophilia. RESULTS: We found that 41\% of the children with CP and 33\% of the controls carry one or more of the studied mutations (P = 0.348). The prevalence of the factor V mutation was 27.9\% in CP and 16.4\% in controls (P= 0.127). The frequency of the other two genetic factors was even less significant. The FVL mutation was found in 35\% of the Arab CP patients (15/42) and in 22\% of the controls from the same population (9/40) (P= 0.067). CONCLUSIONS: Each of the genetic factors studied was shown to be related to CP. Despite the high frequency of FVL among the studied patients, we were unable to prove a significant correlation between FVL and CP, mainly because this factor is frequent in the Arab control group. In this population a trend toward significance can be seen (P= 0.067). Larger studies are needed to validate the significance of these results.}, added-at = {2014-07-20T09:30:00.000+0200}, author = {Yehezkely-Schildkraut, Vered and Kutai, Miriam and Hugeirat, Yaser and Levin, Carina and Shalev, Stavit Alon and Mazor, Galia and Koren, Ariel}, biburl = {https://www.bibsonomy.org/bibtex/267dcbd6e884b0b5c09d19dab61c3ffb9/ar0berts}, groups = {public}, interhash = {2a7a2167c61ea5c3aa2d97714a3296e9}, intrahash = {67dcbd6e884b0b5c09d19dab61c3ffb9}, journal = {Isr Med Assoc J}, keywords = {Adolescent; Arabs; Case-Control Studies; Cerebral Palsy; Child; Child, Preschool; Factor V; Female; Humans; Infant; Israel; Jews; Male; Methylenetetrahydrofolate Dehydrogenase (NADP); Prothrombin; Risk Factors; Thrombophilia}, month = Dec, number = 12, pages = {808--811}, pmid = {16382706}, timestamp = {2014-07-20T09:30:00.000+0200}, title = {Thrombophilia: a risk factor for cerebral palsy?}, username = {ar0berts}, volume = 7, year = 2005 }