An enhanced understanding of the cellular characteristics contributing to ongoing brain injury following intrapartum hypoxia-ischemia has resulted in the implementation of targeted neuroprotective strategies in the newborn period. This review briefly covers the pathogenesis of hypoxic-ischemic injury with an emphasis on reperfusion injury; the role of magnetic resonance imaging in the detection of such injury, and focuses on potential strategies both supportive and neuroprotective to prevent ongoing injury with a specific emphasis on modest hypothermia.
%0 Journal Article
%1 Shalak2004
%A Shalak, Lina
%A Perlman, Jeffrey M
%D 2004
%J Early Hum Dev
%K Brain; Cerebral Palsy; Humans; Hypothermia, Induced; Hypoxia-Ischemia, Infant, Newborn; Magnetic Resonance Imaging; Neuroprotective Agents; Reperfusion Injury
%N 2
%P 125--141
%R 10.1016/j.earlhumdev.2004.06.003
%T Hypoxic-ischemic brain injury in the term infant-current concepts.
%U http://dx.doi.org/10.1016/j.earlhumdev.2004.06.003
%V 80
%X An enhanced understanding of the cellular characteristics contributing to ongoing brain injury following intrapartum hypoxia-ischemia has resulted in the implementation of targeted neuroprotective strategies in the newborn period. This review briefly covers the pathogenesis of hypoxic-ischemic injury with an emphasis on reperfusion injury; the role of magnetic resonance imaging in the detection of such injury, and focuses on potential strategies both supportive and neuroprotective to prevent ongoing injury with a specific emphasis on modest hypothermia.
@article{Shalak2004,
abstract = {An enhanced understanding of the cellular characteristics contributing to ongoing brain injury following intrapartum hypoxia-ischemia has resulted in the implementation of targeted neuroprotective strategies in the newborn period. This review briefly covers the pathogenesis of hypoxic-ischemic injury with an emphasis on reperfusion injury; the role of magnetic resonance imaging in the detection of such injury, and focuses on potential strategies both supportive and neuroprotective to prevent ongoing injury with a specific emphasis on modest hypothermia.},
added-at = {2014-07-19T21:19:41.000+0200},
author = {Shalak, Lina and Perlman, Jeffrey M},
biburl = {https://www.bibsonomy.org/bibtex/267f19a120a796f39d7f233508a1f2bb1/ar0berts},
doi = {10.1016/j.earlhumdev.2004.06.003},
groups = {public},
interhash = {a0cd9732338b57a42d84625662501474},
intrahash = {67f19a120a796f39d7f233508a1f2bb1},
journal = {Early Hum Dev},
keywords = {Brain; Cerebral Palsy; Humans; Hypothermia, Induced; Hypoxia-Ischemia, Infant, Newborn; Magnetic Resonance Imaging; Neuroprotective Agents; Reperfusion Injury},
month = Nov,
number = 2,
pages = {125--141},
pii = {S0378-3782(04)00101-X},
pmid = {15500993},
timestamp = {2014-07-19T21:19:41.000+0200},
title = {Hypoxic-ischemic brain injury in the term infant-current concepts.},
url = {http://dx.doi.org/10.1016/j.earlhumdev.2004.06.003},
username = {ar0berts},
volume = 80,
year = 2004
}