%0 Journal Article %1 Schwikowski2000Network %A Schwikowski, B. %A Uetz, P. %A Fields, S. %C The Institute for Systems Biology, 4225 Roosevelt Way NE, Suite 200, Seattle, WA 98105, USA. %D 2000 %I Nature Publishing Group %J Nature biotechnology %K protein\_interaction, proteins, yeast networks biological-networks %N 12 %P 1257--1261 %R 10.1038/82360 %T A network of protein-protein interactions in yeast. %U http://dx.doi.org/10.1038/82360 %V 18 %X A global analysis of 2,709 published interactions between proteins of the yeast Saccharomyces cerevisiae has been performed, enabling the establishment of a single large network of 2,358 interactions among 1,548 proteins. Proteins of known function and cellular location tend to cluster together, with 63\% of the interactions occurring between proteins with a common functional assignment and 76\% occurring between proteins found in the same subcellular compartment. Possible functions can be assigned to a protein based on the known functions of its interacting partners. This approach correctly predicts a functional category for 72\% of the 1,393 characterized proteins with at least one partner of known function, and has been applied to predict functions for 364 previously uncharacterized proteins.

@article{Schwikowski2000Network, abstract = {{A global analysis of 2,709 published interactions between proteins of the yeast Saccharomyces cerevisiae has been performed, enabling the establishment of a single large network of 2,358 interactions among 1,548 proteins. Proteins of known function and cellular location tend to cluster together, with 63\% of the interactions occurring between proteins with a common functional assignment and 76\% occurring between proteins found in the same subcellular compartment. Possible functions can be assigned to a protein based on the known functions of its interacting partners. This approach correctly predicts a functional category for 72\% of the 1,393 characterized proteins with at least one partner of known function, and has been applied to predict functions for 364 previously uncharacterized proteins.}}, added-at = {2019-06-10T14:53:09.000+0200}, address = {The Institute for Systems Biology, 4225 Roosevelt Way NE, Suite 200, Seattle, WA 98105, USA.}, author = {Schwikowski, B. and Uetz, P. and Fields, S.}, biburl = {https://www.bibsonomy.org/bibtex/26a5572df3da768f1f37902f5ad43f661/nonancourt}, citeulike-article-id = {1293006}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/82360}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nbt1200\_1257}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/11101803}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=11101803}, day = 01, doi = {10.1038/82360}, interhash = {0a71c1666dca989fa3e273755c989f16}, intrahash = {6a5572df3da768f1f37902f5ad43f661}, issn = {1087-0156}, journal = {Nature biotechnology}, keywords = {protein\_interaction, proteins, yeast networks biological-networks}, month = dec, number = 12, pages = {1257--1261}, pmid = {11101803}, posted-at = {2008-10-16 11:43:15}, priority = {2}, publisher = {Nature Publishing Group}, timestamp = {2019-07-31T13:50:37.000+0200}, title = {{A network of protein-protein interactions in yeast.}}, url = {http://dx.doi.org/10.1038/82360}, volume = 18, year = 2000 }