Analysis of genomic segments shared identical-by-descent (IBD) between
individuals is fundamental to many genetic applications, but IBD detection
accuracy in non-simulated data is largely unknown. Using 25,432 genotyped
European individuals, and exploiting known familial relationships in 2,952
father-mother-child trios contained therein, we identify a false positive rate
over 67% for short (2-4 centiMorgan) segments. We introduce a novel,
computationally-efficient, haplotype-based metric that enables accurate IBD
detection on population-scale datasets.
%0 Generic
%1 durand2013reducing
%A Durand, Eric Y.
%A Eriksson, Nicholas
%A McLean, Cory Y.
%D 2013
%K IBD false_positives methods pedigrees
%T Reducing pervasive false positive identical-by-descent segments detected
by large-scale pedigree analysis
%U http://arxiv.org/abs/1311.1120
%X Analysis of genomic segments shared identical-by-descent (IBD) between
individuals is fundamental to many genetic applications, but IBD detection
accuracy in non-simulated data is largely unknown. Using 25,432 genotyped
European individuals, and exploiting known familial relationships in 2,952
father-mother-child trios contained therein, we identify a false positive rate
over 67% for short (2-4 centiMorgan) segments. We introduce a novel,
computationally-efficient, haplotype-based metric that enables accurate IBD
detection on population-scale datasets.
@misc{durand2013reducing,
abstract = {Analysis of genomic segments shared identical-by-descent (IBD) between
individuals is fundamental to many genetic applications, but IBD detection
accuracy in non-simulated data is largely unknown. Using 25,432 genotyped
European individuals, and exploiting known familial relationships in 2,952
father-mother-child trios contained therein, we identify a false positive rate
over 67% for short (2-4 centiMorgan) segments. We introduce a novel,
computationally-efficient, haplotype-based metric that enables accurate IBD
detection on population-scale datasets.},
added-at = {2013-11-16T22:51:08.000+0100},
author = {Durand, Eric Y. and Eriksson, Nicholas and McLean, Cory Y.},
biburl = {https://www.bibsonomy.org/bibtex/26dc00ebeadf2b0c402342b28773a88e1/peter.ralph},
interhash = {69dfda66ad5ba4b7955ea4ffe1f43a5a},
intrahash = {6dc00ebeadf2b0c402342b28773a88e1},
keywords = {IBD false_positives methods pedigrees},
note = {cite arxiv:1311.1120},
timestamp = {2015-01-20T22:35:53.000+0100},
title = {Reducing pervasive false positive identical-by-descent segments detected
by large-scale pedigree analysis},
url = {http://arxiv.org/abs/1311.1120},
year = 2013
}