Receptor tyrosine kinases (RTKs) are essential components of signal transduction pathways that mediate cell-to-cell communication. These single-pass transmembrane receptors, which bind polypeptide ligands - mainly growth factors - play key roles in processes such as cellular growth, differentiation, metabolism and motility. Recent progress has been achieved towards an understanding of the precise (and varied) mechanisms by which RTKs are activated by ligand binding and by which signals are propagated from the activated receptors to downstream targets in the cell
%0 Journal Article
%1 Hubbard.2007
%A Hubbard, S. R.
%A Miller, W. T.
%D 2007
%J Curr.Opin.Cell Biol.
%K Activation Animals Binding Biological Coenzymes Conformation Cross-Talk Enzyme Humans Kinase Kinases Ligands Models Protein Protein-Tyrosine Receptor Research Signal Transduction Tyrosine metabolism pharmacology
%N 2
%P 117-123
%T Receptor tyrosine kinases: mechanisms of activation and signaling
%U PM:17306972
%V 19
%X Receptor tyrosine kinases (RTKs) are essential components of signal transduction pathways that mediate cell-to-cell communication. These single-pass transmembrane receptors, which bind polypeptide ligands - mainly growth factors - play key roles in processes such as cellular growth, differentiation, metabolism and motility. Recent progress has been achieved towards an understanding of the precise (and varied) mechanisms by which RTKs are activated by ligand binding and by which signals are propagated from the activated receptors to downstream targets in the cell
@article{Hubbard.2007,
abstract = {Receptor tyrosine kinases (RTKs) are essential components of signal transduction pathways that mediate cell-to-cell communication. These single-pass transmembrane receptors, which bind polypeptide ligands - mainly growth factors - play key roles in processes such as cellular growth, differentiation, metabolism and motility. Recent progress has been achieved towards an understanding of the precise (and varied) mechanisms by which RTKs are activated by ligand binding and by which signals are propagated from the activated receptors to downstream targets in the cell},
added-at = {2010-02-05T11:28:39.000+0100},
author = {Hubbard, S. R. and Miller, W. T.},
biburl = {https://www.bibsonomy.org/bibtex/27006f0426f910dc9e19ab2973b68d79a/kanefendt},
interhash = {69d61d328c23b5355bc51c8d3e2ff838},
intrahash = {7006f0426f910dc9e19ab2973b68d79a},
journal = {Curr.Opin.Cell Biol.},
keywords = {Activation Animals Binding Biological Coenzymes Conformation Cross-Talk Enzyme Humans Kinase Kinases Ligands Models Protein Protein-Tyrosine Receptor Research Signal Transduction Tyrosine metabolism pharmacology},
number = 2,
pages = {117-123},
timestamp = {2010-02-05T11:28:57.000+0100},
title = {Receptor tyrosine kinases: mechanisms of activation and signaling},
url = {PM:17306972},
volume = 19,
year = 2007
}