The saturated fatty acids released from the erythrocyte membranes of four patients with adrenoleukodystrophy (ALD) and 14 diseased controls were analyzed by high performance liquid chromatography. The ratios of C26:0 to other saturated fatty acids in ALD were higher than those of diseased controls, and neither false-positive nor false-negative samples were observed. These results suggest that a study of fatty acids of total glycerophospholipids in erythrocyte membranes by high performance liquid chromatography is a useful diagnostic method of ALD.
%0 Journal Article
%1 Antoku1985
%A Antoku, Y.
%A Sakai, T.
%A Goto, I.
%A Katafuchi, Y.
%A Sato, H.
%A Iwashita, H.
%A Kuroiwa, Y.
%D 1985
%J Acta Neurol Scand
%K Adrenoleukodystrophy; Adult; Cerebral Palsy; Chemistry; Child; Diffuse Sclerosis of Schilder; Erythrocyte Membrane; Fatty Acids; Humans; Male; Membrane Lipids; Muscular Dystrophies; Phosphatidic Acids
%N 2
%P 193--197
%T Adrenoleukodystrophy: fatty acid analysis of total glycerophospholipids in erythrocyte membranes.
%V 72
%X The saturated fatty acids released from the erythrocyte membranes of four patients with adrenoleukodystrophy (ALD) and 14 diseased controls were analyzed by high performance liquid chromatography. The ratios of C26:0 to other saturated fatty acids in ALD were higher than those of diseased controls, and neither false-positive nor false-negative samples were observed. These results suggest that a study of fatty acids of total glycerophospholipids in erythrocyte membranes by high performance liquid chromatography is a useful diagnostic method of ALD.
@article{Antoku1985,
abstract = {The saturated fatty acids released from the erythrocyte membranes of four patients with adrenoleukodystrophy (ALD) and 14 diseased controls were analyzed by high performance liquid chromatography. The ratios of C26:0 to other saturated fatty acids in ALD were higher than those of diseased controls, and neither false-positive nor false-negative samples were observed. These results suggest that a study of fatty acids of total glycerophospholipids in erythrocyte membranes by high performance liquid chromatography is a useful diagnostic method of ALD.},
added-at = {2014-07-19T17:42:07.000+0200},
author = {Antoku, Y. and Sakai, T. and Goto, I. and Katafuchi, Y. and Sato, H. and Iwashita, H. and Kuroiwa, Y.},
biburl = {https://www.bibsonomy.org/bibtex/2756e7abafb9fbd06fdadbef7be97225b/ar0berts},
groups = {public},
interhash = {14fa185db27f52682528417cc6926327},
intrahash = {756e7abafb9fbd06fdadbef7be97225b},
journal = {Acta Neurol Scand},
keywords = {Adrenoleukodystrophy; Adult; Cerebral Palsy; Chemistry; Child; Diffuse Sclerosis of Schilder; Erythrocyte Membrane; Fatty Acids; Humans; Male; Membrane Lipids; Muscular Dystrophies; Phosphatidic Acids},
month = Aug,
number = 2,
pages = {193--197},
pmid = {4050328},
timestamp = {2014-07-19T17:42:07.000+0200},
title = {Adrenoleukodystrophy: fatty acid analysis of total glycerophospholipids in erythrocyte membranes.},
username = {ar0berts},
volume = 72,
year = 1985
}