%0 Journal Article %1 Taylor2005a %A Taylor, C. %A Draget, K. I. %A Pearson, J. P. %A Smidsrod, O. %C 1155 16TH ST, NW, WASHINGTON, DC 20036 USA %D 2005 %I AMER CHEMICAL SOC %J Biomacromolecules %K ;; [ISI:] cervical-mucus; crystallinity; gastric gel glycoproteins liquid mucins; mucociliary mucus mucus; ocular pedal respiratory rheology; structure; transport; %N 3 %P 1524 -- 1530 %T Mucous systems show a novel mechanical response to applied deformation %V 6 %X Mucous secretions have a wide range of biological functions that are intimately linked with their rheological properties. In addition, many mucous secretions are exposed to significant stress and deformation during physiological function. This study has examined the rheological response of three mucous systems, native pig gastric mucus, purified mucin gels, and mucin alginate gels, to increasing applied stress to a level sufficient to induce flow behavior. A novel, frequency-dependent stress hardening was observed in all three systems. This hardening behavior may play a significant role in the ability of mucous systems to resist mechanical disruption in the physiological state.

@article{Taylor2005a, __markedentry = {[phpts:6]}, abstract = {Mucous secretions have a wide range of biological functions that are intimately linked with their rheological properties. In addition, many mucous secretions are exposed to significant stress and deformation during physiological function. This study has examined the rheological response of three mucous systems, native pig gastric mucus, purified mucin gels, and mucin alginate gels, to increasing applied stress to a level sufficient to induce flow behavior. A novel, frequency-dependent stress hardening was observed in all three systems. This hardening behavior may play a significant role in the ability of mucous systems to resist mechanical disruption in the physiological state.}, added-at = {2011-11-04T13:47:04.000+0100}, address = {1155 16TH ST, NW, WASHINGTON, DC 20036 USA}, author = {Taylor, C. and Draget, K. I. and Pearson, J. P. and Smidsrod, O.}, authoraddress = {Norwegian Univ Sci & Technol, Dept Biotechnol, Norwegian Biopolymer Lab, N-7491 Trondheim, Norway. ; Univ Newcastle Upon Tyne, Sch Med, Sch Cell & Mol Biosci, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England.}, biburl = {https://www.bibsonomy.org/bibtex/27717c4e2a275f81dd1aa91fff208f1e0/pawelsikorski}, citedref = {ALLEN A, 1993, EUR J GASTROEN HEPAT, V5, P193 ; APP EM, 1997, PULM PHARMACOL THER, V10, P271 ; BELL AE, 1984, INT J BIOL MACROMOL, V6, P309 ; BELL AE, 1985, GASTROENTEROLOGY, V88, P269 ; BERRY MS, 2001, INVEST OPHTH VIS S S, V42, S258 ; BRAYSHAW DJ, 2003, ULTRAMICROSCOPY, V97, P289 ; BROMBERG LE, 2000, BIOMACROMOLECULES, V1, P325 ; CHEN Y, 2004, AM J RESP CELL MOL, V30, P155 ; CHRETIEN FC, 1987, BIORHEOLOGY, V24, P420 ; CHRETIEN FC, 2003, ACTA OBSTET GYN SCAN, V82, P449 ; DAVIDSON HJ, 2004, VET OPHTHALMOL, V7, P71 ; DAVIES JM, 1998, THERMOCHIM ACTA, V315, P39 ; DAWSON M, 2003, J BIOL CHEM, V278, P50393 ; DENNY M, 1978, BIORHEOLOGY, V15, P460 ; DENNY MW, 1980, NATURE, V285, P160 ; DENNY MW, 1984, AM ZOOL, V24, P23 ; DENNY MW, 1989, S SOC EXPT BIOL, V43, P337 ; DODD S, 1998, EUR BIOPHYS J BIOPHY, V28, P38 ; FITZGERALD JE, 1989, ARCH OTOLARYNGOL, V115, P462 ; FOGG FJJ, 1996, BIOCHEM J 3, V316, P937 ; FUONGFUCHAT A, 1996, CARBOHYD RES, V284, P85 ; GENDLER SJ, 1995, ANNU REV PHYSIOL, V57, P607 ; GODL K, 2002, J BIOL CHEM, V277, P47248 ; GROOT RD, 1996, J CHEM PHYS, V104, P9202 ; HARDING SE, 1995, BIOPHYS CHEM, V55, P69 ; KAVANAGH GM, 1998, PROG POLYM SCI, V23, P533 ; KING M, 1979, BIORHEOLOGY, V16, P57 ; KLEIN J, 1994, NATURE, V370, P634 ; LIN JZ, 2001, AM J PHYSIOL-LUNG C, V280, L1155 ; MA LL, 1999, J BIOL CHEM, V274, P19145 ; MACCHIONE M, 1995, RESP PHYSIOL, V99, P165 ; MICHON C, 2004, FOOD HYDROCOLLOID, V18, P999 ; MIKKELSEN A, 1985, BIOPOLYMERS, V24, P1683 ; PEREZVILAR J, 1999, J BIOL CHEM, V274, P31751 ; QURAISHI MS, 1998, CLIN OTOLARYNGOL, V23, P403 ; RAYNAL BDE, 2003, J BIOL CHEM, V278, P28703 ; RUBIN BK, 1990, AM REV RESPIR DIS, V141, P1040 ; SELLERS LA, 1988, BIOCHEM J, V256, P599 ; SELLERS LA, 1991, BIOCHIM BIOPHYS ACTA, V1115, P174 ; SHEEHAN JK, 1991, AM REV RESPIR DIS, V144, S4 ; TAYLOR C, 2003, BIOMACROMOLECULES, V4, P922 ; TAYLOR C, 2004, BBA-GEN SUBJECTS, V1672, P131 ; TAYLOR C, 2004, IN PRESS CARBOHYDR P ; THIM L, 2002, EUR J CLIN INVEST, V32, P519 ; VINEY C, 1993, MACROMOLECULES, V26, P852 ; VINEY C, 1999, BIORHEOLOGY, V36, P319 ; WAIGH TA, 2002, LANGMUIR, V18, P7188}, interhash = {1111bff88dab4eddebf4919147392156}, intrahash = {7717c4e2a275f81dd1aa91fff208f1e0}, isifile-dt = {Article}, isifile-em = {catherine.taylor@nt.ntnu.no}, isifile-ga = {926QY}, isifile-j9 = {BIOMACROMOLECULES}, isifile-nr = {47}, isifile-pi = {WASHINGTON}, isifile-rp = {Taylor, C, Norwegian Univ Sci & Technol, Dept Biotechnol, Norwegian ; Biopolymer Lab, Sem Saelands Vei 6-8, N-7491 Trondheim, Norway.}, isifile-sc = {Biochemistry & Molecular Biology; Chemistry, Organic; Polymer Science}, isifile-tc = {0}, issn = {1525-7797}, journal = {Biomacromolecules}, keywords = {;; [ISI:] cervical-mucus; crystallinity; gastric gel glycoproteins liquid mucins; mucociliary mucus mucus; ocular pedal respiratory rheology; structure; transport;}, language = {English}, month = {MAY-JUN}, number = 3, owner = {phpts}, pages = {1524 -- 1530}, publisher = {AMER CHEMICAL SOC}, size = {7 p.}, sourceid = {ISI:000229138900047}, timestamp = {2011-11-04T13:47:25.000+0100}, title = {Mucous systems show a novel mechanical response to applied deformation}, volume = 6, year = 2005 }