Zusammenfassung
Purpose To investigate the potential of real-time magnetic
particle imaging (MPI) to guide percutaneous transluminal
angioplasty (PTA) of vascular stenoses in a phantom
model.
Materials and Methods Experiments were conducted on a
custom-built MPI scanner. Vascular stenosis phantoms
consisted of polyvinyl chloride tubes (inner diameter
8 mm) prepared with a centrally aligned cable tie to
form * 50% stenoses. MPI angiography for visualization
of stenoses was performed using the superparamagnetic
iron oxide nanoparticle-based contrast agent Ferucarbotran
(10 mmol (Fe)/l). Balloon catheters and guidewires for
PTA were visualized using custom-made lacquer markers
based on Ferucarbotran. Stenosis dilation (n = 3) was
performed by manually inflating the PTA balloon with
diluted Ferucarbotran. An online reconstruction framework
was implemented for real-time imaging with very short
latency time.
Results Visualization of stenosis phantoms and guidance
of interventional instruments in real-time (4 frames/
s, * 100 ms latency time) was possible using an online
reconstruction algorithm. Labeling of guidewires and balloon
catheters allowed for precise visualization of instrument
positions.
Conclusion Real-time MPI-guided PTA in a phantom
model is feasible.
Nutzer