%0 Journal Article %1 pemberton2013population %A Pemberton, T J %A Degiorgio, M %A Rosenberg, N A %D 2013 %J G3 (Bethesda) %K datasets human_genome microsattelites %N 5 %P 891-907 %R 10.1534/g3.113.005728 %T Population structure in a comprehensive genomic data set on human microsatellite variation %U http://www.ncbi.nlm.nih.gov/pubmed/23550135 %V 3 %X Over the past two decades, microsatellite genotypes have provided the data for landmark studies of human population-genetic variation. However, the various microsatellite data sets have been prepared with different procedures and sets of markers, so that it has been difficult to synthesize available data for a comprehensive analysis. Here, we combine eight human population-genetic data sets at the 645 microsatellite loci they share in common, accounting for procedural differences in the production of the different data sets, to assemble a single data set containing 5795 individuals from 267 worldwide populations. We perform a systematic analysis of genetic relatedness, detecting 240 intra-population and 92 inter-population pairs of previously unidentified close relatives and proposing standardized subsets of unrelated individuals for use in future studies. We then augment the human data with a data set of 84 chimpanzees at the 246 loci they share in common with the human samples. Multidimensional scaling and neighbor-joining analyses of these data sets offer new insights into the structure of human populations and enable a comparison of genetic variation patterns in chimpanzees with those in humans. Our combined data sets are the largest of their kind reported to date and provide a resource for use in human population-genetic studies.

@article{pemberton2013population, abstract = {Over the past two decades, microsatellite genotypes have provided the data for landmark studies of human population-genetic variation. However, the various microsatellite data sets have been prepared with different procedures and sets of markers, so that it has been difficult to synthesize available data for a comprehensive analysis. Here, we combine eight human population-genetic data sets at the 645 microsatellite loci they share in common, accounting for procedural differences in the production of the different data sets, to assemble a single data set containing 5795 individuals from 267 worldwide populations. We perform a systematic analysis of genetic relatedness, detecting 240 intra-population and 92 inter-population pairs of previously unidentified close relatives and proposing standardized subsets of unrelated individuals for use in future studies. We then augment the human data with a data set of 84 chimpanzees at the 246 loci they share in common with the human samples. Multidimensional scaling and neighbor-joining analyses of these data sets offer new insights into the structure of human populations and enable a comparison of genetic variation patterns in chimpanzees with those in humans. Our combined data sets are the largest of their kind reported to date and provide a resource for use in human population-genetic studies.}, added-at = {2013-06-19T01:49:21.000+0200}, author = {Pemberton, T J and Degiorgio, M and Rosenberg, N A}, biburl = {https://www.bibsonomy.org/bibtex/28dc38731ffe87d0c75a5a584c4e830e0/peter.ralph}, doi = {10.1534/g3.113.005728}, interhash = {0e60f2a9d6e0876d353bc51cea36f797}, intrahash = {8dc38731ffe87d0c75a5a584c4e830e0}, journal = {G3 (Bethesda)}, keywords = {datasets human_genome microsattelites}, number = 5, pages = {891-907}, pmid = {23550135}, timestamp = {2013-06-19T01:49:21.000+0200}, title = {Population structure in a comprehensive genomic data set on human microsatellite variation}, url = {http://www.ncbi.nlm.nih.gov/pubmed/23550135}, volume = 3, year = 2013 }