%0 Journal Article %1 duveau2018fitness %A Duveau, Fabien %A Hodgins-Davis, Andrea %A Metzger, Brian PH %A Yang, Bing %A Tryban, Stephen %A Walker, Elizabeth A %A Lybrook, Tricia %A Wittkopp, Patricia J %D 2018 %E Barkai, Naama %E Verstrepen, Kevin J %I eLife Sciences Publications, Ltd %J eLife %K competitive_evolution gene_expression reading_group regulatory_evolution regulatory_networks yeast %P e37272 %R 10.7554/eLife.37272 %T Fitness effects of altering gene expression noise in Saccharomyces cerevisiae %U https://doi.org/10.7554/eLife.37272 %V 7 %X Gene expression noise is an evolvable property of biological systems that describes differences in expression among genetically identical cells in the same environment. Prior work has shown that expression noise is heritable and can be shaped by selection, but the impact of variation in expression noise on organismal fitness has proven difficult to measure. Here, we quantify the fitness effects of altering expression noise for the TDH3 gene in Saccharomyces cerevisiae. We show that increases in expression noise can be deleterious or beneficial depending on the difference between the average expression level of a genotype and the expression level maximizing fitness. We also show that a simple model relating single-cell expression levels to population growth produces patterns consistent with our empirical data. We use this model to explore a broad range of average expression levels and expression noise, providing additional insight into the fitness effects of variation in expression noise.

@article{duveau2018fitness, abstract = {Gene expression noise is an evolvable property of biological systems that describes differences in expression among genetically identical cells in the same environment. Prior work has shown that expression noise is heritable and can be shaped by selection, but the impact of variation in expression noise on organismal fitness has proven difficult to measure. Here, we quantify the fitness effects of altering expression noise for the \textit{TDH3} gene in \textit{Saccharomyces cerevisiae}. We show that increases in expression noise can be deleterious or beneficial depending on the difference between the average expression level of a genotype and the expression level maximizing fitness. We also show that a simple model relating single-cell expression levels to population growth produces patterns consistent with our empirical data. We use this model to explore a broad range of average expression levels and expression noise, providing additional insight into the fitness effects of variation in expression noise.}, added-at = {2018-09-28T20:24:01.000+0200}, article_type = {journal}, author = {Duveau, Fabien and Hodgins-Davis, Andrea and Metzger, Brian PH and Yang, Bing and Tryban, Stephen and Walker, Elizabeth A and Lybrook, Tricia and Wittkopp, Patricia J}, biburl = {https://www.bibsonomy.org/bibtex/2909688fb4b5e7c829eef8aae6691b6af/peter.ralph}, citation = {eLife 2018;7:e37272}, doi = {10.7554/eLife.37272}, editor = {Barkai, Naama and Verstrepen, Kevin J}, interhash = {7067e3ac88825c25b69f013598d38ffc}, intrahash = {909688fb4b5e7c829eef8aae6691b6af}, issn = {2050-084X}, journal = {eLife}, keywords = {competitive_evolution gene_expression reading_group regulatory_evolution regulatory_networks yeast}, month = aug, pages = {e37272}, pub_date = {2018-08-20}, publisher = {eLife Sciences Publications, Ltd}, timestamp = {2018-09-28T21:01:20.000+0200}, title = {Fitness effects of altering gene expression noise in \textit{Saccharomyces cerevisiae}}, url = {https://doi.org/10.7554/eLife.37272}, volume = 7, year = 2018 }